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Tns3 Gene Detail
Summary
  • Symbol
    Tns3
  • Name
    tensin 3
  • Synonyms
    F830010I22Rik, TEM6, Tens1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443012
    NCBI Gene: 319939
  • Alliance
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:8431652-8664535 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 4.99 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1457 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443012
protein coding gene Chr11:8431652-8664737 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018035
protein coding gene Chr11:5644141-5888236 (-)
A/J MGP_AJ_G0018008
protein coding gene Chr11:5405360-5643368 (-)
AKR/J MGP_AKRJ_G0017972
protein coding gene Chr11:5599222-5836518 (-)
BALB/cJ MGP_BALBcJ_G0017976
protein coding gene Chr11:5394211-5628049 (-)
C3H/HeJ MGP_C3HHeJ_G0017789
protein coding gene Chr11:5518594-5762099 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018428
protein coding gene Chr11:5792646-6036509 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016086
protein coding gene Chr11:5144855-5378242 (-)
CAST/EiJ MGP_CASTEiJ_G0017351
protein coding gene Chr11:5514695-5783217 (-)
CBA/J MGP_CBAJ_G0017764
protein coding gene Chr11:6306912-6569119 (-)
DBA/2J MGP_DBA2J_G0017874
protein coding gene Chr11:5339954-5578594 (-)
FVB/NJ MGP_FVBNJ_G0017866
protein coding gene Chr11:5321228-5554254 (-)
LP/J MGP_LPJ_G0017945
protein coding gene Chr11:5672742-5922791 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017892
protein coding gene Chr11:5895096-6145504 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018468
protein coding gene Chr11:5728532-5976809 (-)
PWK/PhJ MGP_PWKPhJ_G0017131
protein coding gene Chr11:5338891-5575447 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016928
protein coding gene Chr11:5594297-5836273 (-)
WSB/EiJ MGP_WSBEiJ_G0017405
protein coding gene Chr11:5488623-5735586 (-)



Homology
more
  • Human Ortholog
    TNS3, tensin 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TNS3, tensin 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TEM6, TENS1
  • Links
    NCBI Gene ID: 64759
    neXtProt AC: NX_Q68CZ2
    UniProt: Q68CZ2

  • Chr Location
    7p12.3; chr7:47275154-47582553 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 49713
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TNS3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit one third postnatal lethality, reduced body weight, growth retardation, smaller digestive tracts with defects in villi and enterocyte differentiation, abnormal lung morphology, and thinner bones with decreased chondrocyte proliferation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020422 Ensembl Gene Model | MGI Sequence Detail 232884 C57BL/6J ±  kb
    transcript ENSMUST00000020695 Ensembl | MGI Sequence Detail 7483 Not Applicable  
    polypeptide ENSMUSP00000020695 Ensembl | MGI Sequence Detail 1440 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 67
      cDNA 67

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2652851
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 3
      Gene Ontology 3
      Phenotypes 11
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:245960 Piprek RP, et al., Cell adhesion molecules expression pattern indicates that somatic cells arbitrate gonadal sex of differentiating bipotential fetal mouse gonad. Mech Dev. 2017 Oct;147:17-27

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory