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Tns3
Gene Detail
Symbol

Name
ID
Tns3
tensin 3
MGI:2443012
Synonyms
F830010I22Rik, TEM6, Tens1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
4.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:8431652-8664535 bp, - strand
From VEGA annotation of GRCm38

  232884 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49713  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: TNS3
Gene Tree: Tns3

Human
homologs
TNS3, tensin 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 64759
neXtProt AC: NX_Q68CZ2

Human Synonyms: TEM6, TENS1

Human Chr (Location): 7p12.3; chr7:47275144-47582553 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(864) : Gene trapped(863) Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele exhibit one third postnatal lethality, reduced body weight, growth retardation, smaller digestive tracts with defects in villi and enterocyte differentiation, abnormal lung morphology, and thinner bones with decreased chondrocyte proliferation.
 
Interactions
Tns3 interacts with 314 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process cell migration, lung alveolus development, ...
Component cell junction, cytoplasm, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (112)    Tissues (19)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 112
cDNA source data(65)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tns3    NEW 
Molecular
reagents
All nucleic(65) cDNA(65)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000005142 (Evidence)
Ensembl Gene Model ENSMUSG00000020422 (Evidence)
Entrez Gene 319939 (Evidence)
UniGene 337820
DFCI TC1644904, TC1598210, TC1627053, TC1603735
DoTS DT.97359245, DT.94196371, DT.101333391, DT.529206, DT.99849293
NIA Mouse Gene Index U032505
Consensus CDS Project CCDS36109.1
International Mouse Phenotyping Consortium Status Tns3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005142 VEGA Gene Model | MGI Sequence Detail 232884 C57BL/6J ±  kb
transcript OTTMUST00000011495 VEGA | MGI Sequence Detail 7483 Not Applicable 
polypeptide OTTMUSP00000005346 VEGA | MGI Sequence Detail 1440 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(15) UniProt(2)
Polymorphisms
SNPs within 2kb(1462 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR020454 Diacylglycerol/phorbol-ester binding
InterPro IPR006020 Phosphotyrosine interaction domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR000980 SH2 domain
InterPro IPR014020 Tensin phosphatase, C2 domain
InterPro IPR013625 Tensin phosphotyrosine-binding domain
Protein Ontology PR:000016522 tensin-3
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(36)
Other
accession IDs
MGI:2652851

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory