Embryos homozygous for a knock-out allele die at E4.0 as blastocysts fail to enter S phase and arrest at G1, leading to elevated cell death. Heterozygous mutant mice display a shortened lifespan due to formation of multiple tumors, mostly large lymphomas of both B and T cells.
|Ensembl Gene Model||ENSMUSG00000041238 (Evidence)|
|Entrez Gene||225182 (Evidence)|
|DFCI||TC1609401, TC1766954, TC1592773, TC1618538, TC1578868|
|DoTS||DT.101281482, DT.50315538, DT.91353758, DT.91579205, DT.99844327, DT.97380918, DT.99844323|
|NIA Mouse Gene Index||U018416|
|Consensus CDS Project||CCDS37738.1|
|International Mouse Knockout Project Status||Rbbp8|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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