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Arfgef1 Gene Detail
Summary
  • Symbol
    Arfgef1
  • Name
    ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)
  • Synonyms
    ARFGEP1, BIG1, D130059B05Rik, D730028O18Rik, P200
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442988
    NCBI Gene: 211673
  • Gene Overview
    MyGene.info: ARFGEF1
Location & Maps
more
  • Sequence Map
    Chr1:10137571-10232670 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      95100 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 2.36 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    ARFGEF1, ADP ribosylation factor guanine nucleotide exchange factor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ARFGEF1, ADP ribosylation factor guanine nucleotide exchange factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARFGEP1, BIG1, P200
  • Links
    NCBI Gene ID: 10565
    neXtProt AC: NX_Q9Y6D6

  • Chr Location
    8q13.2; chr8:67175296-67343897 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotype references
  • All Mutations and Alleles
    13
  • Gene trapped
    11
  • Targeted
    2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033923 VEGA Gene Model | MGI Sequence Detail 95100 C57BL/6J ±  kb
transcript OTTMUST00000085577 VEGA | MGI Sequence Detail 6978 Not Applicable  
polypeptide OTTMUSP00000046250 VEGA | MGI Sequence Detail 1846 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    586 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 177
    cDNA 177

    Microarray probesets 6
Other
Accession IDs
less
MGI:2441988
References
more
  • Summaries
    All 27
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:213869 Caronia-Brown G, et al., The cortical hem regulates the size and patterning of neocortex. Development. 2014 Jul;141(14):2855-65

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory