Arglu1 MGI Mouse Gene Detail - MGI:2442985 - arginine and glutamate rich 1

Symbol

Arglu1
Name

arginine and glutamate rich 1
Synonyms

9430010O03Rik

Feature Type

protein coding gene
IDs

MGI:2442985
NCBI Gene: 234023
Gene Overview

MyGene.info: ARGLU1
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr8:8666297-8690550 bp, - strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 3.57 cM
Mapping Data

1 experiment

SNPs within 2kb

78 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442985	protein coding gene	Chr8:8665075-8690550 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033343	protein coding gene	Chr8:5739521-5763463 (-)
A/J	MGP_AJ_G0033323	protein coding gene	Chr8:5554865-5578809 (-)
AKR/J	MGP_AKRJ_G0033255	protein coding gene	Chr8:5735538-5759491 (-)
BALB/cJ	MGP_BALBcJ_G0033324	protein coding gene	Chr8:5690855-5715182 (-)
C3H/HeJ	MGP_C3HHeJ_G0033038	protein coding gene	Chr8:5890608-5917420 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033836	protein coding gene	Chr8:6012446-6037106 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030807	protein coding gene	Chr8:5147037-5171925 (-)
CAST/EiJ	MGP_CASTEiJ_G0032360	protein coding gene	Chr8:5556843-5582205 (-)
CBA/J	MGP_CBAJ_G0033011	protein coding gene	Chr8:6271801-6297581 (-)
DBA/2J	MGP_DBA2J_G0033164	protein coding gene	Chr8:5565047-5589380 (-)
FVB/NJ	MGP_FVBNJ_G0033112	protein coding gene	Chr8:5507887-5531821 (-)
LP/J	MGP_LPJ_G0033258	protein coding gene	Chr8:5647382-5673412 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033147	protein coding gene	Chr8:6695183-6719158 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033853	protein coding gene	Chr8:5727878-5751804 (-)
PWK/PhJ	MGP_PWKPhJ_G0032073	protein coding gene	Chr8:5496772-5521836 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031915	protein coding gene	Chr8:5619782-5642911 (-)
WSB/EiJ	MGP_WSBEiJ_G0032476	protein coding gene	Chr8:5785806-5810660 (-)

Human Ortholog

ARGLU1, arginine and glutamate rich 1

Vertebrate Orthologs

10

Human Ortholog

ARGLU1, arginine and glutamate rich 1
Orthology source: HomoloGene, HGNC
Links

HGNC:25482

NCBI Gene ID: 55082

neXtProt AC: NX_Q9NWB6

UniProt: Q9NWB6
Chr Location

13q33.3; chr13:106543314-106568166 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 9960
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: ARGLU1
Protein SuperFamily

uncharacterized conserved protein
Gene Tree

Arglu1

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

1
Gene trapped

6
Targeted

4
Incidental Mutations

APF
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit embryonic growth retardation, increased brain apoptosis, and complete embryonic lethality during organogenesis.

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All GO Annotations

5
GO References

2

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

657
Tissues

2
cDNA Data

16
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase arglu1

ZFIN arglu1a, arglu1b

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Arglu1 interacts with 151 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

54
RefSeq

6
UniProt

4
CCDS

CCDS40215.1

Ensembl

ENSMUSG00000040459 (Evidence)
NCBI Gene

234023

			Length	Strain/Species	Flank
genomic	234023	NCBI Gene Model \| MGI Sequence Detail	24254	C57BL/6J	± kb
transcript	NM_176849	RefSeq \| MGI Sequence Detail	1731	C57BL/6
polypeptide	Q3UL36	UniProt \| EBI \| MGI Sequence Detail	271	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000004217 arginine and glutamate-rich protein 1

(term hierarchy)
InterPro Domains

IPR033371 Arginine and glutamate-rich protein 1

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All nucleic 16

cDNA 16

Microarray probesets 6

Summaries

All 24

Developmental Gene Expression 2

Gene Ontology 2

Phenotypes 6
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:273438 Magomedova L, et al., ARGLU1 is a transcriptional coactivator and splicing regulator important for stress hormone signaling and development. Nucleic Acids Res. 2019 Apr 8;47(6):2856-2870

TSS for Arglu1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr80310	Chr8:8690493-8690538 (-)	34 bp
Tssr80309	Chr8:8690481-8690492 (-)	63 bp
Tssr80308	Chr8:8690041-8690116 (-)	471 bp
Tssr80307	Chr8:8689838-8689871 (-)	695 bp
Tssr80306	Chr8:8683091-8683099 (-)	7,455 bp
Tssr80305	Chr8:8667128-8667136 (-)	23,418 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 02/23/2021 MGI 6.16