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Rab8b
Gene Detail
Symbol

Name
ID
Rab8b
RAB8B, member RAS oncogene family
MGI:2442982
Synonyms
D330025I23Rik, Rab8b
Feature Type
protein coding gene
Genetic Map
Chromosome 9
36.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:66843672-66919705 bp, - strand
From Ensembl annotation of GRCm38

  76034 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69220  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RAB8B
Protein SuperFamily: Ras-related protein Rab
Gene Tree: Rab8b

Human
homologs
RAB8B, RAB8B, member RAS oncogene family
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 51762
neXtProt AC: NX_Q92930

Human Chr (Location): 15q22.2; chr15:63189529-63267776 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit no overt abnormalities and normal survival.
 
Interactions
Rab8b interacts with 417 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process adherens junction organization, antigen processing and presentation, ...
Component cell tip, cytoplasmic vesicle, ...
Function GDP binding, GTPase activity, ...
External Resources: FuncBase
Expression
cDNA source data(87)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rab8b ; ZFIN rab8b    NEW 
Molecular
reagents
All nucleic(87) cDNA(87)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000036943 (Evidence)
Entrez Gene 235442 (Evidence)
UniGene 260376
DFCI TC1597954, TC1576178
DoTS DT.91287729, DT.55157764
NIA Mouse Gene Index U031026
Consensus CDS Project CCDS23309.1
International Mouse Phenotyping Consortium Status Rab8b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036943 Ensembl Gene Model | MGI Sequence Detail 76034 C57BL/6J ±  kb
transcript ENSMUST00000041139 Ensembl | MGI Sequence Detail 4743 Not Applicable 
polypeptide ENSMUSP00000041857 Ensembl | MGI Sequence Detail 207 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(350 from dbSNP Build 137)    SNPs within 2kb including multiple locations(368)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR003579 Small GTPase superfamily, Rab type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000013643 ras-related protein Rab-8B
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:211898 Sato T, et al., Rab8a and Rab8b are essential for several apical transport pathways but insufficient for ciliogenesis. J Cell Sci. 2014 Jan 15;127(Pt 2):422-31
All references(30)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory