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Ism1 Gene Detail
Summary
  • Symbol
    Ism1
  • Name
    isthmin 1, angiogenesis inhibitor
  • Synonyms
    5430433G21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442963
    NCBI Gene: 319909
Location & Maps
more
  • Sequence Map
    Chr2:139678178-139758580 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      80403 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 69.06 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ISM1, isthmin 1, angiogenesis inhibitor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ISM1, isthmin 1, angiogenesis inhibitor
    Orthology source: HomoloGene
  • Synonyms
    bA149I18.1, C20orf82, dJ1077I2.1, ISM, Isthmin
  • Links
    NCBI Gene ID: 140862
    neXtProt AC: NX_B1AKI9

  • Chr Location
    20p12.1; chr20:13221771-13300650 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 19061
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: ISM1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Ism1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015588 VEGA Gene Model | MGI Sequence Detail 80403 C57BL/6J ±  kb
transcript OTTMUST00000037021 VEGA | MGI Sequence Detail 2964 Not Applicable  
polypeptide OTTMUSP00000016609 VEGA | MGI Sequence Detail 461 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    703 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 5
    cDNA 4
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2139269
References
more
  • Summaries
    All 24
    Developmental Gene Expression 4
    Gene Ontology 2
    Phenotypes 4
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:210449 Osorio L, et al., Distinct spatiotemporal expression of ISM1 during mouse and chick development. Cell Cycle. 2014 May 15;13(10):1571-82

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory