About   Help   FAQ
Skic2 Gene Detail
Summary
  • Symbol
    Skic2
  • Name
    SKI2 subunit of superkiller complex
  • Synonyms
    4930534J06Rik, Ski2w, Skiv2l
  • Feature Type
    protein coding gene
  • IDs
    MGI:1099835
    NCBI Gene: 108077
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:35058202-35069180 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.39 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1099835
 protein coding gene Chr17:35058202-35069186 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023591
 protein coding gene Chr17:34951045-34962027 (-)
A/J MGP_AJ_G0023553
 protein coding gene Chr17:33809484-33820395 (-)
AKR/J MGP_AKRJ_G0023519
 protein coding gene Chr17:34268285-34279266 (-)
BALB/cJ MGP_BALBcJ_G0023558
 protein coding gene Chr17:33939796-33950707 (-)
C3H/HeJ MGP_C3HHeJ_G0023318
 protein coding gene Chr17:34667656-34678637 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023998
 protein coding gene Chr17:36288355-36299337 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021477
 protein coding gene Chr17:31573996-31584873 (-)
CAST/EiJ MGP_CASTEiJ_G0022816
 protein coding gene Chr17:34663395-34674383 (-)
CBA/J MGP_CBAJ_G0023296
 protein coding gene Chr17:37799904-37810885 (-)
DBA/2J MGP_DBA2J_G0023424
 protein coding gene Chr17:33123611-33134751 (-)
FVB/NJ MGP_FVBNJ_G0023391
 protein coding gene Chr17:32953930-32964999 (-)
LP/J MGP_LPJ_G0023501
 protein coding gene Chr17:35261901-35272883 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023414
 protein coding gene Chr17:36728724-36739637 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024040
 protein coding gene Chr17:34497395-34509170 (-)
PWK/PhJ MGP_PWKPhJ_G0022565
 protein coding gene Chr17:31953303-31964327 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022382
 protein coding gene Chr17:32499294-32510347 (-)
WSB/EiJ MGP_WSBEiJ_G0022878
 protein coding gene Chr17:34606999-34617900 (-)



Homology
more
  • Human Ortholog
    SKIC2, SKI2 subunit of superkiller complex
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SKIC2, SKI2 subunit of superkiller complex
  • Synonyms
    170A, DDX13, HLP, SKI2, SKI2W, SKIV2, SKIV2L, SKIV2L1, THES2
  • Links
    NCBI Gene ID: 6499
    neXtProt AC: NX_Q15477
    UniProt: Q15477

  • Chr Location
    6p21.33; chr6:31959116-31969818 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SKIC2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E6.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    119
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 108077 NCBI Gene Model | MGI Sequence Detail 10979 C57BL/6J ±  kb
    transcript NM_021337 RefSeq | MGI Sequence Detail 3972 C57BL/6  
    polypeptide Q6NZR5 UniProt | EBI | MGI Sequence Detail 1244 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 120
      Genomic 1
      cDNA 119

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2147055, MGI:2148488, MGI:2442955
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 9
    • Earliest
      J:43702 Gee S, et al., Cloning of mDEAH9, a putative RNA helicase and mammalian homologue of Saccharomyces cerevisiae splicing factor Prp43. Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):11803-7
    • Latest
      J:321268 Yang K, et al., Cytoplasmic RNA quality control failure engages mTORC1-mediated autoinflammatory disease. J Clin Invest. 2022 Jan 18;132(2):e146176
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory