Caskin1 MGI Mouse Gene Detail - MGI:2442952 - CASK interacting protein 1

Symbol

Caskin1
Name

CASK interacting protein 1
Synonyms

3300002N10Rik, C630036E02Rik, mKIAA1306

Feature Type

protein coding gene
IDs

MGI:2442952
NCBI Gene: 268932
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr17:24707575-24727645 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 12.40 cM, cytoband A3.3
Mapping Data

2 experiments

SNPs within 2kb

369 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442952	protein coding gene	Chr17:24706871-24727883 (+)
129S1/SvImJ	ENSMUSG00200052807	protein coding gene	Chr17:20153431-20174595 (+)
A/J	ENSMUSG00195049855	protein coding gene	Chr17:21172259-21193491 (+)
AKR/J	ENSMUSG00220025046	protein coding gene	Chr17:20218634-20239864 (+)
BALB/cJ	ENSMUSG00180035401	protein coding gene	Chr17:20445877-20467128 (+)
C3H/HeJ	ENSMUSG00175043363	protein coding gene	Chr17:20204399-20225539 (+)
C57BL/6NJ	ENSMUSG00215050598	protein coding gene	Chr17:20215132-20236311 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021189	protein coding gene	Chr17:20308975-20329942 (+)
CAST/EiJ	ENSTCUG00005048652	protein coding gene	Chr17:20785330-20806681 (+)
CBA/J	ENSMUSG00210037245	protein coding gene	Chr17:20043124-20064369 (+)
DBA/2J	ENSMUSG00185050308	protein coding gene	Chr17:22260592-22281823 (+)
FVB/NJ	ENSMUSG00205033562	protein coding gene	Chr17:20512187-20533681 (+)
JF1/MsJ	ENSUMUG00000057000	protein coding gene	Chr17:21707051-21728168 (+)
LP/J	ENSMUSG00230054551	protein coding gene	Chr17:23658096-23679322 (+)
NOD/ShiLtJ	ENSMUSG00190050157	protein coding gene	Chr17:20149342-20170568 (+)
NZO/HlLtJ	ENSMUSG00225053971	protein coding gene	Chr17:25579729-25600955 (+)
PWK/PhJ	ENSLUMG00010017576	protein coding gene	Chr17:19616436-19637523 (+)
SPRET/EiJ	ENSMSPG00010046140	protein coding gene	Chr17:20952179-20973254 (+)
WSB/EiJ	ENSIUOG00005049216	protein coding gene	Chr17:20898186-20919438 (+)

Human Ortholog

CASKIN1, CASK interacting protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CASKIN1, CASK interacting protein 1
Synonyms

ANKS5A
Links

HGNC:20879

NCBI Gene ID: 57524

UniProt: Q8WXD9
Chr Location

16p13.3; chr16:2177180-2196605 (-) GRCh38

MGI Vertebrate Homology

Caskin1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CASKIN1
Gene Tree

Caskin1

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Phenotype Summary

23 phenotypes from 3 alleles in 3 genetic backgrounds
6 phenotypes from multigenic genotypes
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

5
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

60 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mice for a null allele exhibit abnormal gait, enhanced nociception, abnormal anxiety-like behavior, strong freezing responses with or without cue tone in contextual and cued-fear conditioning tasks and low memory retention. Double homozygous KO with Caskin2 affects synapse efficacy in the brain and leads to spatial learning and novel object recognition deficits.

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All GO Annotations

16
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

699
Tissues

25
cDNA Data

51
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase caskin1

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All Sequences

55
RefSeq

14
UniProt

2
CCDS

CCDS50013.1, CCDS89007.1

Ensembl

ENSMUSG00000033597 (Evidence)
NCBI Gene

268932

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033597	Ensembl Gene Model \| MGI Sequence Detail	20071	C57BL/6J	± kb
transcript	ENSMUST00000024958	Ensembl \| MGI Sequence Detail	5938	Not Applicable
polypeptide	ENSMUSP00000024958	Ensembl \| MGI Sequence Detail	1431	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005052 caskin-1

(term hierarchy)
PDB

8Z8W
InterPro Domains

IPR002110 Ankyrin repeat

IPR033635 Ankyrin repeat and SAM domain-containing protein 1/Caskin

IPR036770 Ankyrin repeat-containing domain superfamily

IPR035497 Caskin1/2, SAM repeat 1

IPR035498 Caskin1/2, SAM repeat 2

IPR032232 Caskin-1, CASK-interaction domain

IPR035495 Caskin-1, SH3 domain

IPR032117 Caskin, C-terminal

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

IPR001660 Sterile alpha motif domain

IPR013761 Sterile alpha motif/pointed domain superfamily
GlyGen

Q6P9K8 7 sites, 1 O-linked glycan (2 sites)

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All nucleic 51

cDNA 51

Microarray probesets 4

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MGI:1919072

Summaries

All 43

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 14
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Caskin1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143038	Chr17:24707378-24707424 (+)	-174 bp
Tssr143039	Chr17:24707557-24707640 (+)	24 bp
Tssr143040	Chr17:24707645-24707656 (+)	76 bp
Tssr143041	Chr17:24707711-24707745 (+)	153 bp
Tssr143042	Chr17:24707747-24707773 (+)	185 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24