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Atad5 Gene Detail
Summary
  • Symbol
    Atad5
  • Name
    ATPase family, AAA domain containing 5
  • Synonyms
    C130052G03Rik, LOC237877
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442925
    NCBI Gene: 237877
Location & Maps
more
  • Sequence Map
    Chr11:80089400-80135794 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      46395 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 47.48 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ATAD5, ATPase family, AAA domain containing 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ATAD5, ATPase family, AAA domain containing 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C17orf41, ELG1, FRAG1
  • Links
    NCBI Gene ID: 79915
    neXtProt AC: NX_Q96QE3

  • Chr Location
    17q11.2; chr17:30831476-30895869 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 32611
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: ATAD5
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 1 allele in 1 genetic background
    1 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    45
  • Chemically induced (other)
    1
  • Gene trapped
    42
  • Targeted
    2
  • Genomic Mutations
    2 involving Atad5
  • Incidental Mutations
Mice homozygous for a gene trap allele exhibit prenatal lethality. Mice heterozygous for a gene trap allele exhibit genomic instability, premature death, and a wide spectrum of spontaneous tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000189 VEGA Gene Model | MGI Sequence Detail 46395 C57BL/6J ±  kb
transcript OTTMUST00000000563 VEGA | MGI Sequence Detail 7266 Not Applicable  
polypeptide OTTMUSP00000000245 VEGA | MGI Sequence Detail 1823 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    177 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000004394 ATPase family AAA domain-containing protein 5
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR003959 ATPase, AAA-type, core
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 66
    cDNA 65
    Other 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:2684863
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 17
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:230702 Zanotti KJ, et al., ATAD5 deficiency decreases B cell division and Igh recombination. J Immunol. 2015 Jan 1;194(1):35-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory