Fbxl21 MGI Mouse Gene Detail - MGI:2442921 - F-box and leucine-rich repeat protein 21

Symbol

Fbxl21
Name

F-box and leucine-rich repeat protein 21
Synonyms

D630045D17Rik, FBL3B, FBXL3B, Psttm

Feature Type

protein coding gene
IDs

MGI:2442921
NCBI Gene: 213311
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr13:56670285-56685711 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 30.07 cM
Mapping Data

1 experiment

SNPs within 2kb

144 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442921	protein coding gene	Chr13:56670201-56685711 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020620	protein coding gene	Chr13:56082688-56099872 (+)
A/J	MGP_AJ_G0020574	protein coding gene	Chr13:53992321-54007739 (+)
AKR/J	MGP_AKRJ_G0020552	protein coding gene	Chr13:55593960-55609481 (+)
BALB/cJ	MGP_BALBcJ_G0020570	protein coding gene	Chr13:54223291-54238714 (+)
C3H/HeJ	MGP_C3HHeJ_G0020369	protein coding gene	Chr13:55398186-55413715 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021004	protein coding gene	Chr13:57775016-57790524 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018586	protein coding gene	Chr13:51931495-51946722 (+)
CAST/EiJ	MGP_CASTEiJ_G0019883	protein coding gene	Chr13:55526008-55547411 (+)
CBA/J	MGP_CBAJ_G0020329	protein coding gene	Chr13:59996601-60012040 (+)
DBA/2J	MGP_DBA2J_G0020452	protein coding gene	Chr13:53538115-53553930 (+)
FVB/NJ	MGP_FVBNJ_G0020431	protein coding gene	Chr13:53011589-53027257 (+)
LP/J	MGP_LPJ_G0020528	protein coding gene	Chr13:56329977-56345457 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020460	protein coding gene	Chr13:59390154-59408963 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021047	protein coding gene	Chr13:55180526-55197312 (+)
PWK/PhJ	MGP_PWKPhJ_G0019639	protein coding gene	Chr13:53576043-53592274 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019466	protein coding gene	Chr13:54128728-54143421 (+)
WSB/EiJ	MGP_WSBEiJ_G0019945	protein coding gene	Chr13:55550494-55567312 (+)

Human Ortholog

FBXL21P, F-box and leucine rich repeat protein 21, pseudogene

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FBXL21P, F-box and leucine rich repeat protein 21, pseudogene
Synonyms

Fbl21, FBL3B, FBXL21, FBXL3B, FBXL3P
Links

HGNC:13600

NCBI Gene ID: 26223

UniProt: Q9UKT6
Chr Location

5q31.1; chr5:135930297-135941996 (+) GRCh38

MGI Vertebrate Homology

Fbxl21 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FBXL21P
Gene Tree

Fbxl21

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Phenotype Summary

5 phenotypes from 4 alleles in 6 genetic backgrounds
2 phenotypes from multigenic genotypes
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

4
Transgenic

2
Genomic Mutations

1 involving Fbxl21
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice with a point mutation exhibit a short circadian free-running period in constant darkness.

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All GO Annotations

16
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

733
Tissues

15
cDNA Data

8
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

55
RefSeq

12
UniProt

5
CCDS

CCDS26563.1, CCDS84026.1, CCDS88461.1

Ensembl

ENSMUSG00000035509 (Evidence)
NCBI Gene

213311

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035509	Ensembl Gene Model \| MGI Sequence Detail	15427	C57BL/6J	± kb
transcript	ENSMUST00000121871	Ensembl \| MGI Sequence Detail	1963	Not Applicable
polypeptide	ENSMUSP00000112518	Ensembl \| MGI Sequence Detail	460	Not Applicable

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UniProt

5 Sequences
InterPro Domains

IPR001810 F-box domain

IPR036047 F-box-like domain superfamily

IPR032675 Leucine-rich repeat domain superfamily

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All nucleic 10

Genomic 2

cDNA 8

Microarray probesets 1

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MGI:3522292

Summaries

All 32

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 15
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:298890 Wirianto M, et al., The GSK-3beta-FBXL21 Axis Contributes to Circadian TCAP Degradation and Skeletal Muscle Function. Cell Rep. 2020 Sep 15;32(11):108140

TSS for Fbxl21:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr120021	Chr13:56670262-56670308 (+)	0 bp
Tssr120022	Chr13:56670310-56670329 (+)	35 bp
Tssr120023	Chr13:56670333-56670353 (+)	58 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23