Rab11fip4 MGI Mouse Gene Detail - MGI:2442920 - RAB11 family interacting protein 4 (class II)

Symbol

Rab11fip4
Name

RAB11 family interacting protein 4 (class II)
Synonyms

A730072L08Rik, mKIAA1821, RAB11-FIP4

Feature Type

protein coding gene
IDs

MGI:2442920
NCBI Gene: 268451
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr11:79482038-79588849 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 46.88 cM
Mapping Data

2 experiments

SNPs within 2kb

540 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442920	protein coding gene	Chr11:79481847-79588849 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018801	protein coding gene	Chr11:80701999-80816865 (+)
A/J	MGP_AJ_G0018768	protein coding gene	Chr11:77597383-77707055 (+)
AKR/J	MGP_AKRJ_G0018738	protein coding gene	Chr11:79922930-80039482 (+)
BALB/cJ	MGP_BALBcJ_G0018741	protein coding gene	Chr11:78005127-78112506 (+)
C3H/HeJ	MGP_C3HHeJ_G0018555	protein coding gene	Chr11:79984701-80097193 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019193	protein coding gene	Chr11:83180723-83298905 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016827	protein coding gene	Chr11:74544674-74651207 (+)
CAST/EiJ	MGP_CASTEiJ_G0018110	protein coding gene	Chr11:80453036-80563027 (+)
CBA/J	MGP_CBAJ_G0018526	protein coding gene	Chr11:86797507-86917885 (+)
DBA/2J	MGP_DBA2J_G0018634	protein coding gene	Chr11:77148463-77257553 (+)
FVB/NJ	MGP_FVBNJ_G0018623	protein coding gene	Chr11:76746808-76855215 (+)
LP/J	MGP_LPJ_G0018704	protein coding gene	Chr11:81212902-81326789 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018650	protein coding gene	Chr11:87097047-87215792 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019233	protein coding gene	Chr11:80185370-80296672 (+)
PWK/PhJ	MGP_PWKPhJ_G0017880	protein coding gene	Chr11:77965726-78076130 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017671	protein coding gene	Chr11:79791919-79904526 (+)
WSB/EiJ	MGP_WSBEiJ_G0018162	protein coding gene	Chr11:80010027-80125060 (+)

Human Ortholog

RAB11FIP4, RAB11 family interacting protein 4

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RAB11FIP4, RAB11 family interacting protein 4
Synonyms

FIP4-Rab11, RAB11-FIP4
Links

HGNC:30267

NCBI Gene ID: 84440

neXtProt AC: NX_Q86YS3

UniProt: Q86YS3
Chr Location

17q11.2; chr17:31391624-31538217 (+) GRCh38.p7

Alliance of Genome Resources

Rab11fip4 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: RAB11FIP4
Gene Tree

Rab11fip4

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

47
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

42
Targeted

2
Genomic Mutations

2 involving Rab11fip4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

44 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

23
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1079
Tissues

97
cDNA Data

12
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA RAB11FIP4

Xenbase rab11fip4

ZFIN rab11fip4a

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Rab11fip4 interacts with 373 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

53
RefSeq

12
UniProt

3
CCDS

CCDS25123.1

Ensembl

ENSMUSG00000017639 (Evidence)
NCBI Gene

268451

			Length	Strain/Species	Flank
genomic	ENSMUSG00000017639	Ensembl Gene Model \| MGI Sequence Detail	106812	C57BL/6J	± kb
transcript	ENSMUST00000017783	Ensembl \| MGI Sequence Detail	7156	Not Applicable
polypeptide	ENSMUSP00000017783	Ensembl \| MGI Sequence Detail	635	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000013583 Rab11 family-interacting protein 4

(term hierarchy)
InterPro Domains

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

IPR037245 FIP-RBD, C-terminal domain superfamily

IPR019018 Rab-binding domain FIP-RBD

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All nucleic 15

cDNA 12

Primer pair 3

Microarray probesets 6

Summaries

All 41

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 16
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:237778 Hara Y, et al., ADP Ribosylation Factor 6 Regulates Neuronal Migration in the Developing Cerebral Cortex through FIP3/Arfophilin-1-dependent Endosomal Trafficking of N-cadherin. eNeuro. 2016 Jul-Aug;3(4):ENEURO.0148-16.2016

TSS for Rab11fip4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103455	Chr11:79481946-79482050 (+)	-40 bp
Tssr103456	Chr11:79543958-79543971 (+)	61,927 bp
Tssr103457	Chr11:79544007-79544012 (+)	61,972 bp
Tssr103458	Chr11:79551358-79551387 (+)	69,335 bp
Tssr103459	Chr11:79551398-79551444 (+)	69,383 bp
Tssr103460	Chr11:79551463-79551474 (+)	69,431 bp
Tssr103461	Chr11:79551500-79551516 (+)	69,470 bp
Tssr103462	Chr11:79551530-79551553 (+)	69,504 bp
Tssr103463	Chr11:79551567-79551578 (+)	69,535 bp
Tssr103464	Chr11:79564757-79564770 (+)	82,726 bp
Tssr103465	Chr11:79585732-79585736 (+)	103,696 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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