Fam171a1 MGI Mouse Gene Detail - MGI:2442917 - family with sequence similarity 171, member A1

Symbol

Fam171a1
Name

family with sequence similarity 171, member A1
Synonyms

9630050M13Rik

Feature Type

protein coding gene
IDs

MGI:2442917
NCBI Gene: 269233
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:3115261-3228843 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 1.73 cM
Mapping Data

2 experiments

SNPs within 2kb

2524 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442917	protein coding gene	Chr2:3115261-3228843 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025302	protein coding gene	Chr2:58999-179984 (+)
A/J	MGP_AJ_G0025278	protein coding gene	Chr2:66739-180676 (+)
AKR/J	MGP_AKRJ_G0025247	protein coding gene	Chr2:64322-171776 (+)
BALB/cJ	MGP_BALBcJ_G0025274	protein coding gene	Chr2:55819-164237 (+)
C3H/HeJ	MGP_C3HHeJ_G0025034	protein coding gene	Chr2:73603-190248 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025717	protein coding gene	Chr2:59424-178972 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023131	protein coding gene	Chr2:20599-136699 (+)
CAST/EiJ	MGP_CASTEiJ_G0024498	protein coding gene	Chr2:60291-181439 (+)
CBA/J	MGP_CBAJ_G0025014	protein coding gene	Chr2:69484-192243 (+)
DBA/2J	MGP_DBA2J_G0025145	protein coding gene	Chr2:55871-168904 (+)
FVB/NJ	MGP_FVBNJ_G0025107	protein coding gene	Chr2:68116-181910 (+)
LP/J	MGP_LPJ_G0025232	protein coding gene	Chr2:67882-199502 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025140	protein coding gene	Chr2:64783-186466 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025775	protein coding gene	Chr2:64367-188336 (+)
PWK/PhJ	MGP_PWKPhJ_G0024247	protein coding gene	Chr2:34325-154274 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024049	protein coding gene	Chr2:66780-190448 (+)
WSB/EiJ	MGP_WSBEiJ_G0024568	protein coding gene	Chr2:67881-185311 (+)

Human Ortholog

FAM171A1, family with sequence similarity 171 member A1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FAM171A1, family with sequence similarity 171 member A1
Synonyms

APCN, C10orf38
Links

HGNC:23522

NCBI Gene ID: 221061

UniProt: Q5VUB5
Chr Location

10p13; chr10:15211643-15374554 (-) GRCh38

MGI Vertebrate Homology

Fam171a1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FAM171A1
Gene Tree

Fam171a1

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References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
38 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

2
Targeted

1
Transgenic

1
Genomic Mutations

1 involving Fam171a1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

52 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

6
GO References

2

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

723
Tissues

4
cDNA Data

53
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FAM171A1

Xenbase fam171a1

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All Sequences

63
RefSeq

16
UniProt

5
CCDS

CCDS38036.1, CCDS79727.1, CCDS84464.1, CCDS89424.1

Ensembl

ENSMUSG00000050530 (Evidence)
NCBI Gene

269233

			Length	Strain/Species	Flank
genomic	269233	NCBI Gene Model \| MGI Sequence Detail	113583	C57BL/6J	± kb
transcript	NM_001081161	RefSeq \| MGI Sequence Detail	4149	C57BL/6
polypeptide	NP_001074630	RefSeq \| MGI Sequence Detail	892	C57BL/6

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UniProt

5 Sequences
InterPro Domains

IPR018890 FAM171

IPR049175 FAM171, C-terminal

IPR048530 FAM171, N-terminal
GlyGen

A2ATK9 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

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All nucleic 53

cDNA 53

Microarray probesets 4

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MGI:2138771

Summaries

All 60

Developmental Gene Expression 1

Diseases 1

Gene Ontology 2

Phenotypes 38
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fam171a1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr15878	Chr2:3115236-3115243 (+)	-21 bp
Tssr15879	Chr2:3115257-3115262 (+)	-1 bp
Tssr15880	Chr2:3119372-3119429 (+)	4,140 bp
Tssr15881	Chr2:3119444-3119513 (+)	4,218 bp
Tssr15882	Chr2:3119560-3119579 (+)	4,309 bp
Tssr15883	Chr2:3120504-3120510 (+)	5,246 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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