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Eda2r Gene Detail
Summary
  • Symbol
    Eda2r
  • Name
    ectodysplasin A2 receptor
  • Synonyms
    9430060M22Rik, Xedar
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442860
    NCBI Gene: 245527
  • Gene Overview
    MyGene.info: EDA2R
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:97333840-97377216 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 42.74 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    120 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442860
protein coding gene ChrX:97333837-97377218 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035930
protein coding gene ChrX:93728326-93770469 (-)
A/J MGP_AJ_G0035915
protein coding gene ChrX:93865071-93916199 (-)
AKR/J MGP_AKRJ_G0035831
protein coding gene ChrX:96455875-96505815 (-)
BALB/cJ MGP_BALBcJ_G0035898
protein coding gene ChrX:92613719-92656904 (-)
C3H/HeJ MGP_C3HHeJ_G0035607
protein coding gene ChrX:94193695-94239267 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036427
protein coding gene ChrX:96648698-96693481 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033257
protein coding gene ChrX:91726706-91769301 (-)
CAST/EiJ MGP_CASTEiJ_G0034894
protein coding gene ChrX:78595194-78653117 (-)
CBA/J MGP_CBAJ_G0035582
protein coding gene ChrX:99586374-99640444 (-)
DBA/2J MGP_DBA2J_G0035736
protein coding gene ChrX:93087388-93133095 (-)
FVB/NJ MGP_FVBNJ_G0035674
protein coding gene ChrX:92477623-92520425 (-)
LP/J MGP_LPJ_G0035826
protein coding gene ChrX:94690617-94734771 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035709
protein coding gene ChrX:103957714-104009412 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036454
protein coding gene ChrX:93448017-93492640 (-)
PWK/PhJ MGP_PWKPhJ_G0034593
protein coding gene ChrX:76272581-76312086 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034421
protein coding gene ChrX:79462983-79505162 (-)
WSB/EiJ MGP_WSBEiJ_G0035033
protein coding gene ChrX:92232660-92278994 (-)



Homology
more
  • Human Ortholog
    EDA2R, ectodysplasin A2 receptor
  • Vertebrate Orthologs
    8
  • Human Ortholog
    EDA2R, ectodysplasin A2 receptor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EDAA2R, EDA-A2R, TNFRSF27, XEDAR
  • Links
    NCBI Gene ID: 60401
    neXtProt AC: NX_Q9HAV5
    UniProt: Q9HAV5

  • Chr Location
    Xq12; chrX:66594384-66639303 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Hemizygous null males are fertile and healthy with no histological abnormalities in any of the major organs.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034457 Ensembl Gene Model | MGI Sequence Detail 43377 C57BL/6J ±  kb
transcript ENSMUST00000037353 Ensembl | MGI Sequence Detail 4752 Not Applicable  
polypeptide ENSMUSP00000041210 Ensembl | MGI Sequence Detail 297 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000006887 tumor necrosis factor receptor superfamily member 27
  • InterPro Domains
    IPR001368 TNFR/NGFR cysteine-rich region
    IPR034060 Tumor necrosis factor receptor 27, N-terminal
    IPR022319 Tumour necrosis factor receptor 27
Molecular
Reagents
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  • All nucleic 21
    cDNA 18
    Primer pair 2
    Other 1

    Microarray probesets 2
References
more
  • Summaries
    All 33
    Developmental Gene Expression 5
    Gene Ontology 7
    Phenotypes 6
  • Earliest
    J:77350 Naito A, et al., TRAF6-deficient mice display hypohidrotic ectodermal dysplasia. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8766-71
  • Latest
    J:260112 Filipova D, et al., Distinct transcriptomic changes in E14.5 mouse skeletal muscle lacking RYR1 or Cav1.1 converge at E18.5. PLoS One. 2018;13(3):e0194428

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory