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Ddx58 Gene Detail
Summary
  • Symbol
    Ddx58
  • Name
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
  • Synonyms
    6430573D20Rik, RIG-I
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442858
    NCBI Gene: 230073
  • Gene Overview
    MyGene.info: DDX58
Location & Maps
more
  • Sequence Map
    Chr4:40203773-40239828 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      36056 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 20.24 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    DDX58, DEXD/H-box helicase 58
  • Vertebrate Orthologs
    7
  • Human Ortholog
    DDX58, DEXD/H-box helicase 58
    Orthology source: HGNC, HomoloGene
  • Synonyms
    RIGI, RIG-I, RLR-1, SGMRT2
  • Links
    NCBI Gene ID: 23586
    neXtProt AC: NX_O95786

  • Chr Location
    9p12; chr9:32455302-32526324 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human DDX58 associations

Human Disease Mouse Models
       Singleton-Merten Syndrome 2; SGMRT2   OMIM: 616298
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 2 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically and radiation induced
    1
  • Gene trapped
    8
  • Targeted
    3
  • Genomic Mutations
    1 involving Ddx58
  • Incidental Mutations
Most homozygotes for a null allele die in utero with liver apoptosis while survivors show impaired IFN induction and succumb to infection with certain RNA viruses. Homozygotes for another null allele are viable but develop colitis and progressive granulocytosis leading to chronic myeloid leukemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006554 VEGA Gene Model | MGI Sequence Detail 36056 C57BL/6J ±  kb
transcript OTTMUST00000014958 VEGA | MGI Sequence Detail 3874 Not Applicable  
polypeptide OTTMUSP00000006916 VEGA | MGI Sequence Detail 926 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    160 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 53
    cDNA 52
    Other 1

    Microarray probesets 5
References
more
  • Summaries
    All 71
    Developmental Gene Expression 2
    Gene Ontology 10
    Phenotypes 36
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:230911 Kozaki T, et al., Role of zinc-finger anti-viral protein in host defense against Sindbis virus. Int Immunol. 2015 Jul;27(7):357-64

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory