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Ddx58
Gene Detail
 Symbol
Name
ID
Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
MGI:2442858
Synonyms 6430573D20Rik, RIG-I
Feature Type protein coding gene
Genetic Map
Chromosome 4
20.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:40203773-40239828 bp, - strand
From VEGA annotation of GRCm38

  36056 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32215  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: interferon-induced helicase C domain-containing protein 1
Gene Tree: Ddx58

Human
homologs
Human Homolog DDX58, DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
NCBI Gene ID 23586
neXtProt AC  NX_O95786
Human Synonyms  RIGI, RIG-I, RLR-1
Human Chr (Location)  9p12; chr9:32455302-32526324 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(8) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Most homozygotes for a null allele die in utero with liver apoptosis while survivors show impaired IFN induction and succumb to infection with certain RNA viruses. Homozygotes for another null allele are viable but develop colitis and progressive granulocytosis leading to chronic myeloid leukemia.
 
Interactions
Ddx58 interacts with 203 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process defense response to virus, detection of virus, ...
Component actin cytoskeleton, cell junction, ...
Function ATP binding, double-stranded DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (35)    Tissues (7)    Images (20)
Theiler Stages: 13, 23
Assay TypeResults
RNA in situ 35
cDNA source data(52)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(53) cDNA(52) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000006554 (Evidence)
Ensembl Gene ModelENSMUSG00000040296 (Evidence)
Entrez Gene230073 (Evidence)
UniGene86382
DFCITC1581908, TC1585905, TC1590548, TC1593942, TC1622080
DoTSDT.101165008, DT.101210136, DT.40146789, DT.91573300, DT.94363082, DT.96085577
NIA Mouse Gene IndexU024953
EC3.6.4.13
PDB3TBK
Consensus CDS ProjectCCDS18043.1
International Mouse Knockout Project StatusDdx58
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006554 VEGA Gene Model | MGI Sequence Detail 36056 C57BL/6J ±  kb
transcript OTTMUST00000014958 VEGA | MGI Sequence Detail 3874 Not Applicable 
polypeptide OTTMUSP00000006916 VEGA | MGI Sequence Detail 926 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(2) UniProt(8)
Polymorphisms SNPs within 2kb(161 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021673 C-terminal domain of RIG-I
InterPro IPR011029 Death-like domain
InterPro IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
InterPro IPR001650 Helicase, C-terminal
InterPro IPR014001 Helicase, superfamily 1/2, ATP-binding domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000029394 ATP-dependent RNA helicase DDX58
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:210542 Li XY, et al., RIG-I modulates Src-mediated AKT activation to restrain leukemic stemness. Mol Cell. 2014 Feb 6;53(3):407-19
All references(70)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory