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Ddx58 Gene Detail
Summary
  • Symbol
    Ddx58
  • Name
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
  • Synonyms
    6430573D20Rik, RIG-I
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442858
    NCBI Gene: 230073
  • Gene Overview
    MyGene.info: DDX58
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:40203777-40239825 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 20.24 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    160 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442858
protein coding gene Chr4:40203773-40239828 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028141
protein coding gene Chr4:38046588-38093950 (-)
A/J MGP_AJ_G0028099
protein coding gene Chr4:36646233-36682371 (-)
AKR/J MGP_AKRJ_G0028062
protein coding gene Chr4:37526870-37567030 (-)
BALB/cJ MGP_BALBcJ_G0028111
protein coding gene Chr4:36949323-36985902 (-)
C3H/HeJ MGP_C3HHeJ_G0027839
protein coding gene Chr4:38109212-38147115 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028552
protein coding gene Chr4:39493978-39534578 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025893
protein coding gene Chr4:34334204-34381186 (-)
CAST/EiJ MGP_CASTEiJ_G0027295
protein coding gene Chr4:37774118-37817845 (-)
CBA/J MGP_CBAJ_G0027811
protein coding gene Chr4:40828570-40864941 (-)
DBA/2J MGP_DBA2J_G0027955
protein coding gene Chr4:36558520-36593859 (-)
FVB/NJ MGP_FVBNJ_G0027922
protein coding gene Chr4:35905810-35943248 (-)
LP/J MGP_LPJ_G0028063
protein coding gene Chr4:38121554-38162508 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027955
protein coding gene Chr4:44193757-44233206 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028611
protein coding gene Chr4:37659329-37700714 (-)
PWK/PhJ MGP_PWKPhJ_G0027013
protein coding gene Chr4:36537323-36580777 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026842
protein coding gene Chr4:37386957-37432284 (-)
WSB/EiJ MGP_WSBEiJ_G0027371
protein coding gene Chr4:37659431-37696407 (-)



Homology
more
  • Human Ortholog
    DDX58, DExD/H-box helicase 58
  • Vertebrate Orthologs
    7
  • Human Ortholog
    DDX58, DExD/H-box helicase 58
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RIGI, RIG-I, RLR-1, SGMRT2
  • Links
    NCBI Gene ID: 23586
    neXtProt AC: NX_O95786
    UniProt: O95786

  • Chr Location
    9p21.1; chr9:32455302-32526324 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 2 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Most homozygotes for a null allele die in utero with liver apoptosis while survivors show impaired IFN induction and succumb to infection with certain RNA viruses. Homozygotes for another null allele are viable but develop colitis and progressive granulocytosis leading to chronic myeloid leukemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 230073 NCBI Gene Model | MGI Sequence Detail 36049 C57BL/6J ±  kb
    transcript NM_172689 RefSeq | MGI Sequence Detail 4943 C57BL/6  
    polypeptide Q6Q899 UniProt | EBI | MGI Sequence Detail 926 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 53
      cDNA 53

      Microarray probesets 5
    References
    more
    • Summaries
      All 96
      Developmental Gene Expression 2
      Gene Ontology 10
      Phenotypes 43
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:265102 Zhu H, et al., RIG-I antiviral signaling drives interleukin-23 production and psoriasis-like skin disease. EMBO Mol Med. 2017 May;9(5):589-604

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory