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Tshz3
Gene Detail
Symbol

Name
ID
Tshz3
teashirt zinc finger family member 3
MGI:2442819
Synonyms
A630038G13Rik, teashirt3, Tsh3, Zfp537
Feature Type
protein coding gene
Genetic Map
Chromosome 7
22.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:36698118-36773553 bp, + strand
From VEGA annotation of GRCm38

  75436 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10835  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TSHZ3
Gene Tree: Tshz3

Human
homologs
TSHZ3, teashirt zinc finger homeobox 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 57616
neXtProt AC: NX_Q63HK5

Human Synonyms: TSH3, ZNF537

Human Chr (Location): 19q12; chr19:31274945-31349284 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit neoatal lethality likely due to respiratory distress and hydroureter and hydronephrosis associated with impaired development of ureteric smooth muscle.
 
Interactions
Tshz3 interacts with 362 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process in utero embryonic development, kidney morphogenesis, ...
Component cell projection, growth cone, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (211)    Tissues (181)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 209
RT-PCR 2
cDNA source data(21)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA TSHZ3 ; Xenbase tshz3 ; ZFIN tshz3b    NEW 
Molecular
reagents
All nucleic(22) cDNA(21) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000040171 (Evidence)
Ensembl Gene Model ENSMUSG00000021217 (Evidence)
Entrez Gene 243931 (Evidence)
UniGene 44141
DFCI TC1582137
DoTS DT.40138279
NIA Mouse Gene Index U007979
Consensus CDS Project CCDS39913.1
International Mouse Phenotyping Consortium Status Tshz3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040171 VEGA Gene Model | MGI Sequence Detail 75436 C57BL/6J ±  kb
transcript OTTMUST00000104432 VEGA | MGI Sequence Detail 5098 Not Applicable 
polypeptide OTTMUSP00000058445 VEGA | MGI Sequence Detail 1081 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(14) UniProt(5)
Polymorphisms
SNPs within 2kb(841 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR027008 Teashirt family
InterPro IPR026810 Teashirt homologue 3
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
Protein Ontology PR:000016727 teashirt homolog 3
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:218980 Yan J, et al., Smad4 regulates ureteral smooth muscle cell differentiation during mouse embryogenesis. PLoS One. 2014;9(8):e104503
All references(49)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory