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Rc3h2 Gene Detail
Summary
  • Symbol
    Rc3h2
  • Name
    ring finger and CCCH-type zinc finger domains 2
  • Synonyms
    2900024N03Rik, 9430019J22Rik, D930043C02Rik, Mnab, Rnf164
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442789
    NCBI Gene: 319817
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:37260081-37312915 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 24.19 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    54 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442789
 protein coding gene Chr2:37260078-37313007 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025693
 protein coding gene Chr2:36054465-36113603 (-)
A/J MGP_AJ_G0025670
 protein coding gene Chr2:34587907-34637680 (-)
AKR/J MGP_AKRJ_G0025640
 protein coding gene Chr2:35733168-35787574 (-)
BALB/cJ MGP_BALBcJ_G0025665
 protein coding gene Chr2:34653813-34702973 (-)
C3H/HeJ MGP_C3HHeJ_G0025426
 protein coding gene Chr2:35661628-35713004 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026111
 protein coding gene Chr2:37101744-37155433 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023516
 protein coding gene Chr2:33255303-33310347 (-)
CAST/EiJ MGP_CASTEiJ_G0024889
 protein coding gene Chr2:35560089-35617730 (-)
CBA/J MGP_CBAJ_G0025405
 protein coding gene Chr2:38486073-38550751 (-)
DBA/2J MGP_DBA2J_G0025537
 protein coding gene Chr2:34334491-34384227 (-)
FVB/NJ MGP_FVBNJ_G0025499
 protein coding gene Chr2:34212401-34264573 (-)
LP/J MGP_LPJ_G0025624
 protein coding gene Chr2:35954167-36008986 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025530
 protein coding gene Chr2:38082982-38145338 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026169
 protein coding gene Chr2:35612712-35665780 (-)
PWK/PhJ MGP_PWKPhJ_G0024631
 protein coding gene Chr2:34224232-34277852 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024436
 protein coding gene Chr2:35725574-35778131 (-)
WSB/EiJ MGP_WSBEiJ_G0024957
 protein coding gene Chr2:35802483-35857425 (-)



Homology
more
  • Human Ortholog
    RC3H2, ring finger and CCCH-type domains 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RC3H2, ring finger and CCCH-type domains 2
  • Synonyms
    MNAB, RNF164
  • Links
    NCBI Gene ID: 54542
    neXtProt AC: NX_Q9HBD1
    UniProt: Q9HBD1

  • Chr Location
    9q33.2; chr9:122844556-122905359 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 4 genetic backgrounds
    20 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a knock-out allele are viable and healthy but show increased TNF production by macrophages in response to LPS. Homozygotes for a different knock-out allele show postnatal lethality, decreased body size and weight, and an immature lung phenotype with decreased alveolar expansion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    4
  • cDNA Data
    11
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000075376 Ensembl Gene Model | MGI Sequence Detail 52835 C57BL/6J ±  kb
    transcript ENSMUST00000112936 Ensembl | MGI Sequence Detail 5828 Not Applicable  
    polypeptide ENSMUSP00000108558 Ensembl | MGI Sequence Detail 1187 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1920113, MGI:1924527
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 20
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:324878 Behrens G, et al., Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses. Nat Immunol. 2021 Dec;22(12):1563-1576
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory