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Tmem169 Gene Detail
Summary
  • Symbol
    Tmem169
  • Name
    transmembrane protein 169
  • Synonyms
    A830020B06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442781
    NCBI Gene: 271711
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:72323554-72342263 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 36.48 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    642 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442781
 protein coding gene Chr1:72323528-72342263 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016130
 protein coding gene Chr1:72783063-72803251 (+)
A/J MGP_AJ_G0016113
 protein coding gene Chr1:70182166-70200475 (+)
AKR/J MGP_AKRJ_G0016070
 protein coding gene Chr1:72196562-72215139 (+)
BALB/cJ MGP_BALBcJ_G0016068
 protein coding gene Chr1:70311658-70331743 (+)
C3H/HeJ MGP_C3HHeJ_G0015899
 protein coding gene Chr1:72511772-72529985 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016521
 protein coding gene Chr1:75603002-75623347 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014242
 protein coding gene Chr1:65897236-65918902 (+)
CAST/EiJ MGP_CASTEiJ_G0015483
 protein coding gene Chr1:71799908-71821149 (+)
CBA/J MGP_CBAJ_G0015872
 protein coding gene Chr1:78063751-78088146 (+)
DBA/2J MGP_DBA2J_G0015973
 protein coding gene Chr1:69582262-69600982 (+)
FVB/NJ MGP_FVBNJ_G0015976
 protein coding gene Chr1:68759216-68778326 (+)
LP/J MGP_LPJ_G0016045
 protein coding gene Chr1:73842432-73862306 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015996
 protein coding gene Chr1:81565718-81586557 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016568
 protein coding gene Chr1:72214785-72249083 (+)
PWK/PhJ MGP_PWKPhJ_G0015270
 protein coding gene Chr1:69025156-69043959 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015049
 protein coding gene Chr1:71601934-71621745 (+)
WSB/EiJ MGP_WSBEiJ_G0015545
 protein coding gene Chr1:72045962-72065748 (+)



Homology
more
  • Human Ortholog
    TMEM169, transmembrane protein 169
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM169, transmembrane protein 169
  • Links
    NCBI Gene ID: 92691
    UniProt: Q96HH4

  • Chr Location
    2q35; chr2:216081866-216102783 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    3
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Tmem169
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    11 strains or lines available
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    13
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 271711 NCBI Gene Model | MGI Sequence Detail 18710 C57BL/6J ±  kb
transcript NM_001418283 RefSeq | MGI Sequence Detail 3034 C57BL/6  
polypeptide Q8BG50 UniProt | EBI | MGI Sequence Detail 297 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 13

    Microarray probesets 3
References
more
  • Summaries
    All 28
    Developmental Gene Expression 1
    Phenotypes 11
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:363654 Wang J, et al., Cortex-Specific Tmem169 Deficiency Induces Defects in Cortical Neuron Development and Autism-Like Behaviors in Mice. J Neurosci. 2025 Feb 26;45(9)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory