Marchf6 MGI Mouse Gene Detail - MGI:2442773 - membrane associated ring-CH-type finger 6

Symbol

Marchf6
Name

membrane associated ring-CH-type finger 6
Synonyms

F830029L24Rik, March6

Feature Type

protein coding gene
IDs

MGI:2442773
NCBI Gene: 223455
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr15:31456037-31531199 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 12.95 cM
Mapping Data

2 experiments

SNPs within 2kb

529 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442773	protein coding gene	Chr15:31456037-31531670 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021766	protein coding gene	Chr15:29694395-29781756 (-)
A/J	MGP_AJ_G0021727	protein coding gene	Chr15:28506703-28583860 (-)
AKR/J	MGP_AKRJ_G0021704	protein coding gene	Chr15:29233132-29313685 (-)
BALB/cJ	MGP_BALBcJ_G0021733	protein coding gene	Chr15:28500132-28591148 (-)
C3H/HeJ	MGP_C3HHeJ_G0021508	protein coding gene	Chr15:29253816-29321283 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022172	protein coding gene	Chr15:30886398-30973166 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019710	protein coding gene	Chr15:26606451-26681691 (-)
CAST/EiJ	MGP_CASTEiJ_G0021024	protein coding gene	Chr15:29741432-29828896 (-)
CBA/J	MGP_CBAJ_G0021477	protein coding gene	Chr15:31762119-31854003 (-)
DBA/2J	MGP_DBA2J_G0021601	protein coding gene	Chr15:28315552-28371331 (-)
FVB/NJ	MGP_FVBNJ_G0021579	protein coding gene	Chr15:27833196-27914001 (-)
LP/J	MGP_LPJ_G0021670	protein coding gene	Chr15:29573339-29643185 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021604	protein coding gene	Chr15:34735517-34834657 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022195	protein coding gene	Chr15:29470973-29558698 (-)
PWK/PhJ	MGP_PWKPhJ_G0020768	protein coding gene	Chr15:28468501-28549231 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020606	protein coding gene	Chr15:29273048-29349349 (-)
WSB/EiJ	MGP_WSBEiJ_G0021080	protein coding gene	Chr15:29435353-29502163 (-)

Human Ortholog

MARCHF6, membrane associated ring-CH-type finger 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MARCHF6, membrane associated ring-CH-type finger 6
Synonyms

DOA10, FAME3, MARCH6, MARCH-VI, RNF176, TEB4
Links

HGNC:30550

NCBI Gene ID: 10299

neXtProt AC: NX_O60337

UniProt: O60337
Chr Location

5p15.2; chr5:10353639-10440388 (+) GRCh38.p7

Alliance of Genome Resources

Marchf6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MARCHF6
Gene Tree

Marchf6

Diseases

1 with human MARCHF6 associations

				Human Disease	Mouse Models
				familial adult myoclonic epilepsy 3 IDs familial adult myoclonic epilepsy 3 DOID:0111695 OMIM:613608

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

12 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

2
Gene trapped

5
Targeted

3
Genomic Mutations

2 involving Marchf6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

17
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

18

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase marchf6

ZFIN marchf6

less

Marchf6 interacts with 387 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

less

All Sequences

53
RefSeq

4
UniProt

2
CCDS

CCDS37054.1

Ensembl

ENSMUSG00000039100 (Evidence)
NCBI Gene

223455

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039100	Ensembl Gene Model \| MGI Sequence Detail	75163	C57BL/6J	± kb
transcript	ENSMUST00000090227	Ensembl \| MGI Sequence Detail	6260	Not Applicable
polypeptide	ENSMUSP00000087694	Ensembl \| MGI Sequence Detail	909	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000010180 E3 ubiquitin-protein ligase MARCHF6

(term hierarchy)
EC

2.3.2.27
InterPro Domains

IPR011016 Zinc finger, RING-CH-type

IPR013083 Zinc finger, RING/FYVE/PHD-type

less

All nucleic 18

cDNA 18

Microarray probesets 5

Summaries

All 37

Gene Ontology 4

Phenotypes 14
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:329236 Nguyen KT, et al., The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis. Nat Cell Biol. 2022 Aug;24(8):1239-1251

TSS for Marchf6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr133939	Chr15:31531227-31531238 (-)	-34 bp
Tssr133938	Chr15:31531145-31531215 (-)	19 bp
Tssr133937	Chr15:31531122-31531138 (-)	69 bp
Tssr133936	Chr15:31530984-31530995 (-)	209 bp
Tssr133935	Chr15:31530969-31530979 (-)	225 bp
Tssr133933	Chr15:31503685-31503688 (-)	27,512 bp
Tssr133932	Chr15:31468117-31468126 (-)	63,077 bp
Tssr133931	Chr15:31468084-31468098 (-)	63,108 bp
Tssr133930	Chr15:31468053-31468067 (-)	63,139 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Copyright, and Privacy Statement Send questions and comments to User Support.	last database update 11/22/2022 MGI 6.22