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Slc43a2 Gene Detail
Summary
  • Symbol
    Slc43a2
  • Name
    solute carrier family 43, member 2
  • Synonyms
    7630402D21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442746
    NCBI Gene: 215113
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:75531694-75577575 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      45882 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 45.92 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    SLC43A2, solute carrier family 43 member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC43A2, solute carrier family 43 member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LAT4
  • Links
    NCBI Gene ID: 124935
    neXtProt AC: NX_Q8N370
    UniProt: Q8N370

  • Chr Location
    17p13.3; chr17:1569254-1630014 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display fetal growth retardation, abnormal placental amino acid transport, slow postnatal weight gain, malnutrition and postnatal lethality, likely as a result of impaired intestinal amino acid absorption.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000006213 VEGA Gene Model | MGI Sequence Detail 45882 C57BL/6J ±  kb
    transcript OTTMUST00000014018 VEGA | MGI Sequence Detail 6891 Not Applicable  
    polypeptide OTTMUSP00000006513 VEGA | MGI Sequence Detail 568 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      280 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000015142 large neutral amino acids transporter small subunit 4
    • InterPro Domains
      IPR027201 Large neutral amino acids transporter small subunit 4
      IPR011701 Major facilitator superfamily
      IPR020846 Major facilitator superfamily domain
      IPR036259 MFS transporter superfamily
    Molecular
    Reagents
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    • All nucleic 70
      cDNA 69
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 13
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:237439 Guetg A, et al., Essential amino acid transporter Lat4 (Slc43a2) is required for mouse development. J Physiol. 2015 Mar 01;593(5):1273-89

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory