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Slc43a2 Gene Detail
Summary
  • Symbol
    Slc43a2
  • Name
    solute carrier family 43, member 2
  • Synonyms
    7630402D21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442746
    NCBI Gene: 215113
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:75531694-75577575 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 45.92 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    280 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442746
protein coding gene Chr11:75529915-75577575 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018717
protein coding gene Chr11:76289800-76337822 (+)
A/J MGP_AJ_G0018683
protein coding gene Chr11:73448766-73495366 (+)
AKR/J MGP_AKRJ_G0018653
protein coding gene Chr11:75673357-75719179 (+)
BALB/cJ MGP_BALBcJ_G0018657
protein coding gene Chr11:73820896-73866707 (+)
C3H/HeJ MGP_C3HHeJ_G0018470
protein coding gene Chr11:75688160-75734747 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019108
protein coding gene Chr11:78698275-78748745 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016743
protein coding gene Chr11:70462635-70508998 (+)
CAST/EiJ MGP_CASTEiJ_G0018024
protein coding gene Chr11:76084385-76133980 (+)
CBA/J MGP_CBAJ_G0018440
protein coding gene Chr11:82137408-82191681 (+)
DBA/2J MGP_DBA2J_G0018549
protein coding gene Chr11:73052564-73098724 (+)
FVB/NJ MGP_FVBNJ_G0018539
protein coding gene Chr11:72613809-72660407 (+)
LP/J MGP_LPJ_G0018620
protein coding gene Chr11:76873115-76918949 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018565
protein coding gene Chr11:82691837-82738854 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019148
protein coding gene Chr11:75882106-75931700 (+)
PWK/PhJ MGP_PWKPhJ_G0017795
protein coding gene Chr11:73751142-73796287 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017586
protein coding gene Chr11:75435099-75488227 (+)
WSB/EiJ MGP_WSBEiJ_G0018077
protein coding gene Chr11:75691635-75740483 (+)



Homology
more
  • Human Ortholog
    SLC43A2, solute carrier family 43 member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC43A2, solute carrier family 43 member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LAT4
  • Links
    NCBI Gene ID: 124935
    neXtProt AC: NX_Q8N370
    UniProt: Q8N370

  • Chr Location
    17p13.3; chr17:1569254-1630014 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display fetal growth retardation, abnormal placental amino acid transport, slow postnatal weight gain, malnutrition and postnatal lethality, likely as a result of impaired intestinal amino acid absorption.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038178 Ensembl Gene Model | MGI Sequence Detail 45882 C57BL/6J ±  kb
    transcript ENSMUST00000042561 Ensembl | MGI Sequence Detail 6891 Not Applicable  
    polypeptide ENSMUSP00000046074 Ensembl | MGI Sequence Detail 568 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000015142 large neutral amino acids transporter small subunit 4
    • InterPro Domains
      IPR027201 Large neutral amino acids transporter small subunit 4
      IPR011701 Major facilitator superfamily
      IPR036259 MFS transporter superfamily
    Molecular
    Reagents
    less
    • All nucleic 71
      cDNA 70
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 13
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:237439 Guetg A, et al., Essential amino acid transporter Lat4 (Slc43a2) is required for mouse development. J Physiol. 2015 Mar 01;593(5):1273-89

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    12/03/2019
    MGI 6.14
    The Jackson Laboratory