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Creb3l2 Gene Detail
Summary
  • Symbol
    Creb3l2
  • Name
    cAMP responsive element binding protein 3-like 2
  • Synonyms
    BBF2H7, C530025K05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442695
    NCBI Gene: 208647
Location & Maps
more
  • Sequence Map
    Chr6:37327255-37442146 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      114892 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CREB3L2, cAMP responsive element binding protein 3-like 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CREB3L2, cAMP responsive element binding protein 3-like 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BBF2H7
  • Links
    NCBI Gene ID: 64764
    neXtProt AC: NX_Q70SY1

  • Chr Location
    7q34; chr7:137874979-138002101 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Gene trapped
    3
  • Targeted
    3
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit severe chondrodysplasia and die shortly after first birth from suffocation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023205 VEGA Gene Model | MGI Sequence Detail 114892 C57BL/6J ±  kb
transcript OTTMUST00000056156 VEGA | MGI Sequence Detail 7082 Not Applicable  
polypeptide OTTMUSP00000026952 VEGA | MGI Sequence Detail 521 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    589 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000005857 cyclic AMP-responsive element-binding protein 3-like protein 2
  • InterPro Domains
    IPR004827 Basic-leucine zipper domain
    IPR029804 cAMP-responsive element-binding protein 3-like protein 2
Molecular
Reagents
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  • All nucleic 14
    cDNA 13
    Primer pair 1

    Microarray probesets 5
References
more
  • Summaries
    All 35
    Developmental Gene Expression 7
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:214120 Hino K, et al., Master regulator for chondrogenesis, Sox9, regulates transcriptional activation of the endoplasmic reticulum stress transducer BBF2H7/CREB3L2 in chondrocytes. J Biol Chem. 2014 May 16;289(20):13810-20

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory