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Slc30a8
Gene Detail
Symbol

Name
ID
Slc30a8
solute carrier family 30 (zinc transporter), member 8
MGI:2442682
Synonyms
C820002P14Rik, ZnT8, ZnT-8
Feature Type
protein coding gene
Genetic Map
Chromosome 15
19.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr15:52295553-52335798 bp, + strand
From VEGA annotation of GRCm38

  40246 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:13795  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cation efflux protein
Gene Tree: Slc30a8

Human
homologs
Human Homolog SLC30A8, solute carrier family 30 (zinc transporter), member 8
NCBI Gene ID 169026
neXtProt AC  NX_Q8IWU4
Human Synonyms  ZnT-8, ZNT8
Human Chr (Location)  8q24.11; chr8:116950273-117176714 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SLC30A8
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit reduced islet zinc levels, circulating insulin levels, and glucose-stimulated insulin secretion.
 
Interactions
Slc30a8 interacts with 96 markers (Mir10a, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (94)    Tissues (94)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000024040 (Evidence)
Ensembl Gene ModelENSMUSG00000022315 (Evidence)
Entrez Gene239436 (Evidence)
UniGene208831
DFCITC1587057
DoTSDT.97357574
NIA Mouse Gene IndexU016243
Consensus CDS ProjectCCDS27464.1
International Mouse Knockout Project StatusSlc30a8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024040 VEGA Gene Model | MGI Sequence Detail 40246 C57BL/6J ±  kb
transcript OTTMUST00000058778 VEGA | MGI Sequence Detail 1971 Not Applicable 
polypeptide OTTMUSP00000028522 VEGA | MGI Sequence Detail 367 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(247 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002524 Cation efflux protein
InterPro IPR027469 Cation efflux protein transmembrane domain
Protein Ontology PR:000015081 zinc transporter 8
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:214752 Gerber PA, et al., Hypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn2+ in pancreatic beta cells. Diabetologia. 2014 Aug;57(8):1635-44
All references(42)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory