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Slc30a8
Gene Detail
Symbol

Name
ID
Slc30a8
solute carrier family 30 (zinc transporter), member 8
MGI:2442682
Synonyms
C820002P14Rik, ZnT8, ZnT-8
Feature Type
protein coding gene
Genetic Map
Chromosome 15
19.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr15:52295553-52335798 bp, + strand
From VEGA annotation of GRCm38

  40246 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:13795  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SLC30A8
Protein SuperFamily: cation efflux protein
Gene Tree: Slc30a8

Human
homologs
SLC30A8, solute carrier family 30 (zinc transporter), member 8
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 169026
neXtProt AC: NX_Q8IWU4

Human Synonyms: ZnT-8, ZNT8

Human Chr (Location): 8q24.11; chr8:116950180-117176714 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SLC30A8

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit reduced islet zinc levels, circulating insulin levels, and glucose-stimulated insulin secretion.
 
Phenotype Images(1)
Interactions
Slc30a8 interacts with 96 markers (Mir10a, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (94)    Tissues (94)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase slc30a8 ; ZFIN slc30a8    NEW 
Molecular
reagents
All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000024040 (Evidence)
Ensembl Gene Model ENSMUSG00000022315 (Evidence)
Entrez Gene 239436 (Evidence)
UniGene 208831
DFCI TC1587057
DoTS DT.97357574
NIA Mouse Gene Index U016243
Consensus CDS Project CCDS27464.1
International Mouse Phenotyping Consortium Status Slc30a8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024040 VEGA Gene Model | MGI Sequence Detail 40246 C57BL/6J ±  kb
transcript OTTMUST00000058778 VEGA | MGI Sequence Detail 1971 Not Applicable 
polypeptide OTTMUSP00000028522 VEGA | MGI Sequence Detail 367 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(247 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002524 Cation efflux protein
InterPro IPR027469 Cation efflux protein transmembrane domain
Protein Ontology PR:000015081 zinc transporter 8
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:218695 Soggia A, et al., von Hippel-Lindau gene disruption in mouse pancreatic progenitors and its consequences on endocrine differentiation in vivo: importance of HIF1-alpha and VEGF-A upregulation. Diabetologia. 2014 Nov;57(11):2348-56
All references(42)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory