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Slc30a8 Gene Detail
Summary
  • Symbol
    Slc30a8
  • Name
    solute carrier family 30 (zinc transporter), member 8
  • Synonyms
    C820002P14Rik, ZnT8, ZnT-8
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442682
    NCBI Gene: 239436
  • Gene Overview
    MyGene.info: SLC30A8
Location & Maps
more
  • Sequence Map
    Chr15:52295553-52335798 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      40246 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 19.88 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    SLC30A8, solute carrier family 30 member 8
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC30A8, solute carrier family 30 member 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ZnT-8, ZNT8
  • Links
    NCBI Gene ID: 169026
    neXtProt AC: NX_Q8IWU4

  • Chr Location
    8q24.11; chr8:116950180-117176714 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human SLC30A8 associations

Human Disease Mouse Models
       Diabetes Mellitus, Noninsulin-Dependent; NIDDM   OMIM: 125853
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 4 alleles in 4 genetic backgrounds
    1 images
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    3 involving Slc30a8
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit reduced islet zinc levels, circulating insulin levels, and glucose-stimulated insulin secretion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024040 VEGA Gene Model | MGI Sequence Detail 40246 C57BL/6J ±  kb
transcript OTTMUST00000058778 VEGA | MGI Sequence Detail 1971 Not Applicable  
polypeptide OTTMUSP00000028522 VEGA | MGI Sequence Detail 367 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    246 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 9
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 43
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 7
    Phenotypes 26
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:234518 Mitchell RK, et al., Molecular Genetic Regulation of Slc30a8/ZnT8 Reveals a Positive Association With Glucose Tolerance. Mol Endocrinol. 2016 Jan;30(1):77-91

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory