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Cdc14a Gene Detail
Summary
  • Symbol
    Cdc14a
  • Name
    CDC14 cell division cycle 14A
  • Synonyms
    A830059A17Rik, Cdc14, CDC14a1, CDC14A2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442676
    NCBI Gene: 229776
  • Gene Overview
    MyGene.info: CDC14A
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:116272553-116424032 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 50.24 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    615 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442676
protein coding gene Chr3:116272553-116428745 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027809
protein coding gene Chr3:118163236-118322848 (-)
A/J MGP_AJ_G0027767
protein coding gene Chr3:114288244-114448765 (-)
AKR/J MGP_AKRJ_G0027733
protein coding gene Chr3:117189092-117349218 (-)
BALB/cJ MGP_BALBcJ_G0027779
protein coding gene Chr3:114138497-114293382 (-)
C3H/HeJ MGP_C3HHeJ_G0027510
protein coding gene Chr3:117544690-117702416 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028225
protein coding gene Chr3:122499598-122662859 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025564
protein coding gene Chr3:109985857-110140749 (-)
CAST/EiJ MGP_CASTEiJ_G0026966
protein coding gene Chr3:116824221-116988117 (-)
CBA/J MGP_CBAJ_G0027485
protein coding gene Chr3:126677249-126857694 (-)
DBA/2J MGP_DBA2J_G0027626
protein coding gene Chr3:113531249-113685632 (-)
FVB/NJ MGP_FVBNJ_G0027594
protein coding gene Chr3:111171736-111324262 (-)
LP/J MGP_LPJ_G0027736
protein coding gene Chr3:119707172-119873632 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027624
protein coding gene Chr3:134044688-134220069 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028281
protein coding gene Chr3:116722181-116880622 (-)
PWK/PhJ MGP_PWKPhJ_G0026692
protein coding gene Chr3:113172323-113326344 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026514
protein coding gene Chr3:114736241-114926273 (-)
WSB/EiJ MGP_WSBEiJ_G0027046
protein coding gene Chr3:117410811-117574738 (-)



Homology
more
  • Human Ortholog
    CDC14A, cell division cycle 14A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CDC14A, cell division cycle 14A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    cdc14, DFNB105, DFNB32, DFNB35, hCDC14
  • Links
    NCBI Gene ID: 8556
    neXtProt AC: NX_Q9UNH5
    UniProt: Q9UNH5

  • Chr Location
    1p21.2; chr1:100345015-100520281 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 75343
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CDC14A
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human CDC14A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033502 Ensembl Gene Model | MGI Sequence Detail 151480 C57BL/6J ±  kb
transcript ENSMUST00000090464 Ensembl | MGI Sequence Detail 4485 Not Applicable  
polypeptide ENSMUSP00000087950 Ensembl | MGI Sequence Detail 603 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000005184 dual specificity protein phosphatase CDC14A
  • EC
  • InterPro Domains
    IPR000340 Dual specificity phosphatase, catalytic domain
    IPR026068 Dual specificity protein phosphatase CDC14A
    IPR020422 Dual specificity protein phosphatase domain
    IPR029260 Dual specificity/tyrosine protein phosphatase, N-terminal
    IPR016130 Protein-tyrosine phosphatase, active site
    IPR003595 Protein-tyrosine phosphatase, catalytic
    IPR029021 Protein-tyrosine phosphatase-like
    IPR000387 Tyrosine specific protein phosphatases domain
Molecular
Reagents
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  • All nucleic 45
    cDNA 43
    Primer pair 1
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 39
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 7
    Phenotypes 8
  • Earliest
    J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
  • Latest
    J:257652 Imtiaz A, et al., CDC14A phosphatase is essential for hearing and male fertility in mouse and human. Hum Mol Genet. 2018 Mar 1;27(5):780-798

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory