About   Help   FAQ
Gene Detail
leucine rich repeat containing 4C
Synonyms 6430556C10Rik, mKIAA1580, netrin g1 ligand
Feature Type protein coding gene
Genetic Map
Chromosome 2
52.30 cM
Detailed Genetic Map ± 1 cM

Mapping data(1)
Sequence Map
Chr2:96318169-97631666 bp, + strand
From VEGA annotation of GRCm38

  1313498 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:18696  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Lrrc4c

Human Homolog LRRC4C, leucine rich repeat containing 4C
NCBI Gene ID 57689
neXtProt AC  NX_Q9HCJ2
Human Synonyms  NGL1, NGL-1
Human Chr (Location)  11p12; chr11:40114199-41459636 (-)  GRCh38
alleles, and
All mutations/alleles(5) : Targeted(5)
Genomic Mutations involving Lrrc4c (2)
Incidental mutations (data from Mutagenetix , APF )
Homozygous mutant mice exhibited an increased mean serum IL-6 response to LPS challenge when compared with controls. No other notable phenotype was detected in a high-througput screen.
Lrrc4c interacts with 264 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
All GO classifications: (17 annotations)
Process regulation of axonogenesis
Component cell junction, extracellular space, ...
Function protein binding
External Resources: FuncBase
Literature Summary: (3 records)
Data Summary: Results (19)    Tissues (16)    Images (3)
Theiler Stages: 17
Assay TypeResults
RNA in situ 19
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(2)
Other database
VEGA Gene ModelOTTMUSG00000014522 (Evidence)
Ensembl Gene ModelENSMUSG00000050587 (Evidence)
Entrez Gene241568 (Evidence)
DFCITC1581163, TC1591054, TC1614668, TC1631133
DoTSDT.101215747, DT.101362608, DT.110738754, DT.60103897, DT.91305081, DT.99848447
NIA Mouse Gene IndexU002155, U255645
Consensus CDS ProjectCCDS16460.1
International Mouse Knockout Project StatusLrrc4c
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014522 VEGA Gene Model | MGI Sequence Detail 1313498 C57BL/6J ±  kb
transcript OTTMUST00000034453 VEGA | MGI Sequence Detail 3646 Not Applicable 
polypeptide OTTMUSP00000049251 VEGA | MGI Sequence Detail 640 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(10) UniProt(2)
Polymorphisms SNPs within 2kb(10143 from dbSNP Build 137)    SNPs within 2kb including multiple locations(10145)
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR001611 Leucine-rich repeat
InterPro IPR026906 Leucine rich repeat 5
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR026878 Leucine-rich repeat-containing protein 4C
InterPro IPR003591 Leucine-rich repeat, typical subtype
Protein Ontology PR:000009937 netrin-G1 ligand
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 5.19
The Jackson Laboratory