Lrrc4c
Gene Detail

Symbol

Name
ID

Lrrc4c
leucine rich repeat containing 4C
MGI:2442636

Synonyms

6430556C10Rik, mKIAA1580, netrin g1 ligand

Feature Type

protein coding gene

Genetic Map

Chromosome 2
52.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr2:96318169-97631666 bp, + strand From VEGA annotation of GRCm38   1313498 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:18696  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Lrrc4c

Human
homologs

Human Homolog		LRRC4C, leucine rich repeat containing 4C
NCBI Gene ID		57689
neXtProt AC		NX_Q9HCJ2
Human Synonyms		NGL1, NGL-1
Human Chr (Location)		11p12; chr11:40114199-41459636 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(5) : Targeted(5)
Genomic Mutations involving Lrrc4c (2)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous mutant mice exhibited an increased mean serum IL-6 response to LPS challenge when compared with controls. No other notable phenotype was detected in a high-througput screen.

 

Interactions

Lrrc4c interacts with 264 markers (Mir7-2, Mir7b, Mir9-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (17 annotations)

Process	regulation of axonogenesis
Component	cell junction, extracellular space, ...
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (3 records)

Data Summary: Results (19)    Tissues (16)    Images (3)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	19

cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(2)

Other database
links

VEGA Gene Model	OTTMUSG00000014522 (Evidence)
Ensembl Gene Model	ENSMUSG00000050587 (Evidence)
Entrez Gene	241568 (Evidence)
DFCI	TC1631133, TC1614668, TC1591054, TC1581163
DoTS	DT.110738754, DT.101362608, DT.101215747, DT.99848447, DT.91305081, DT.60103897
NIA Mouse Gene Index	U002155, U255645
Consensus CDS Project	CCDS16460.1
International Mouse Knockout Project Status	Lrrc4c

Sequences

Length	Strain/Species
genomic	OTTMUSG00000014522	VEGA Gene Model | MGI Sequence Detail	1313498	C57BL/6J
transcript	OTTMUST00000034453	VEGA | MGI Sequence Detail	3646	Not Applicable
polypeptide	OTTMUSP00000049251	VEGA | MGI Sequence Detail	640	Not Applicable

All sequences(55) RefSeq(10) UniProt(3)

Polymorphisms

SNPs within 2kb(10143 from dbSNP Build 137)    SNPs within 2kb including multiple locations(10145)

Protein-related
information

Resource	ID	Description
InterPro	IPR000483	Cysteine-rich flanking region, C-terminal
InterPro	IPR013098	Immunoglobulin I-set
InterPro	IPR007110	Immunoglobulin-like domain
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003598	Immunoglobulin subtype 2
InterPro	IPR001611	Leucine-rich repeat
InterPro	IPR026906	Leucine rich repeat 5
InterPro	IPR000372	Leucine-rich repeat-containing N-terminal
InterPro	IPR026878	Leucine-rich repeat-containing protein 4C
InterPro	IPR003591	Leucine-rich repeat, typical subtype
Protein Ontology	PR:000009937	netrin-G1 ligand

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(34)