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Lrrc4c Gene Detail
Summary
  • Symbol
    Lrrc4c
  • Name
    leucine rich repeat containing 4C
  • Synonyms
    6430556C10Rik, mKIAA1580, netrin g1 ligand
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442636
    NCBI Gene: 241568
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:96318169-97631666 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 52.30 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    10046 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442636
protein coding gene Chr2:96318169-97631672 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026187
protein coding gene Chr2:97933196-99299983 (+)
A/J MGP_AJ_G0026148
protein coding gene Chr2:93957203-95245908 (+)
AKR/J MGP_AKRJ_G0026129
protein coding gene Chr2:96562195-97906189 (+)
BALB/cJ MGP_BALBcJ_G0026157
protein coding gene Chr2:94150863-95470794 (+)
C3H/HeJ MGP_C3HHeJ_G0025908
protein coding gene Chr2:96830201-98172597 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026608
protein coding gene Chr2:101210125-102618479 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023999
protein coding gene Chr2:90201642-91448804 (+)
CAST/EiJ MGP_CASTEiJ_G0025373
protein coding gene Chr2:97405963-98762442 (+)
CBA/J MGP_CBAJ_G0025886
protein coding gene Chr2:104734519-106191253 (+)
DBA/2J MGP_DBA2J_G0026022
protein coding gene Chr2:93538810-94831530 (+)
FVB/NJ MGP_FVBNJ_G0025985
protein coding gene Chr2:92649735-93919282 (+)
LP/J MGP_LPJ_G0026126
protein coding gene Chr2:98117073-99483820 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026011
protein coding gene Chr2:107825632-109604506 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026662
protein coding gene Chr2:96667013-98018969 (+)
PWK/PhJ MGP_PWKPhJ_G0025108
protein coding gene Chr2:93237100-94541330 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024909
protein coding gene Chr2:96161141-97458299 (+)
WSB/EiJ MGP_WSBEiJ_G0025440
protein coding gene Chr2:97240393-98600577 (+)



Homology
more
  • Human Ortholog
    LRRC4C, leucine rich repeat containing 4C
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LRRC4C, leucine rich repeat containing 4C
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NGL1, NGL-1
  • Links
    NCBI Gene ID: 57689
    neXtProt AC: NX_Q9HCJ2
    UniProt: Q9HCJ2

  • Chr Location
    11p12; chr11:40107066-41460212 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 18696
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LRRC4C
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibited an increased mean serum IL-6 response to LPS challenge when compared with controls. No other notable phenotype was detected in a high-througput screen.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000050587 Ensembl Gene Model | MGI Sequence Detail 1313498 C57BL/6J ±  kb
    transcript ENSMUST00000135431 Ensembl | MGI Sequence Detail 3646 Not Applicable  
    polypeptide ENSMUSP00000130984 Ensembl | MGI Sequence Detail 640 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 12
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:269738 Guerreiro I, et al., Reorganisation of Hoxd regulatory landscapes during the evolution of a snake-like body plan. Elife. 2016 Aug 1;5

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    11/26/2019
    MGI 6.14
    The Jackson Laboratory