Lrrc4c MGI Mouse Gene Detail - MGI:2442636 - leucine rich repeat containing 4C

Lrrc4c Gene Detail

Symbol

Lrrc4c
Name

leucine rich repeat containing 4C
Synonyms

6430556C10Rik, mKIAA1580, netrin g1 ligand

Feature Type

protein coding gene
IDs

MGI:2442636
NCBI Gene: 241568

Sequence Map

Chr2:96318169-97631666 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

1313498 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 52.30 cM
Mapping Data

1 experiment

Human Ortholog

LRRC4C, leucine rich repeat containing 4C

Vertebrate Orthologs

10

Human Ortholog

LRRC4C, leucine rich repeat containing 4C
Orthology source: HomoloGene, HGNC
Synonyms

NGL1, NGL-1
Links

HGNC:29317

NCBI Gene ID: 57689

neXtProt AC: NX_Q9HCJ2
Chr Location

11p12; chr11:40109938-41460212 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 18696
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: LRRC4C
Gene Tree

Lrrc4c

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Radiation induced

1
Targeted

5
Genomic Mutations

4 involving Lrrc4c
Incidental Mutations

Mutagenetix , APF

Homozygous mutant mice exhibited an increased mean serum IL-6 response to LPS challenge when compared with controls. No other notable phenotype was detected in a high-througput screen.

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All GO Annotations

22
GO References

7

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

19
Tissues

16
cDNA Data

10
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase lrrc4c

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Lrrc4c interacts with 263 markers (Mir7-2, Mir7b, Mir9-1, ...) View All

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All Sequences

47
RefSeq

14
UniProt

2
CCDS

CCDS16460.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000014522	VEGA Gene Model \| MGI Sequence Detail	1313498	C57BL/6J	± kb
transcript	OTTMUST00000034453	VEGA \| MGI Sequence Detail	3646	Not Applicable
polypeptide	OTTMUSP00000049251	VEGA \| MGI Sequence Detail	640	Not Applicable

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SNPs within 2kb

10046 from dbSNP Build 142

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UniProt

2 Sequences
Protein Ontology

PR:000009937 netrin-G1 ligand
InterPro Domains

IPR013098 Immunoglobulin I-set

IPR007110 Immunoglobulin-like domain

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR013106 Immunoglobulin V-set domain

IPR001611 Leucine-rich repeat

IPR026906 Leucine rich repeat 5

IPR026878 Leucine-rich repeat-containing protein 4C

IPR032675 Leucine-rich repeat domain, L domain-like

IPR000372 Leucine-rich repeat N-terminal domain

IPR003591 Leucine-rich repeat, typical subtype

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All nucleic 11

cDNA 10

Primer pair 1

Microarray probesets 2

Summaries

All 31

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 11
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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