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Nup133 Gene Detail
Summary
  • Symbol
    Nup133
  • Name
    nucleoporin 133
  • Synonyms
    4832420O05Rik, mermaid
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442620
    NCBI Gene: 234865
  • Gene Overview
    MyGene.info: NUP133
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:123897123-123949265 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      52143 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 72.27 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    NUP133, nucleoporin 133
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NUP133, nucleoporin 133
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hNUP133
  • Links
    NCBI Gene ID: 55746
    neXtProt AC: NX_Q8WUM0
    UniProt: Q8WUM0

  • Chr Location
    1q42.13; chr1:229440995-229508343 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32402
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NUP133
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 2 alleles in 4 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit embryonic lethality prior to E10.5, abnormal somitogenesis, pericardial edema, growth retardation, and abnormal neural development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000062005 VEGA Gene Model | MGI Sequence Detail 52143 C57BL/6J ±  kb
    transcript OTTMUST00000151388 VEGA | MGI Sequence Detail 5808 Not Applicable  
    polypeptide OTTMUSP00000078517 VEGA | MGI Sequence Detail 1155 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      664 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000011507 nuclear pore complex protein Nup133
    • InterPro Domains
      IPR037624 Nuclear pore complex protein Nup133-like
      IPR007187 Nucleoporin, Nup133/Nup155-like, C-terminal
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 124
      cDNA 123
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:3578197
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 8
    • Earliest
      J:114003 Belgareh N, et al., An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells. J Cell Biol. 2001 Sep 17;154(6):1147-60
    • Latest
      J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory