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Nup133
Gene Detail
 Symbol
Name
ID
Nup133
nucleoporin 133
MGI:2442620
Synonyms 4832420O05Rik, mermaid
Feature Type protein coding gene
Genetic Map
Chromosome 8
72.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:123897123-123949265 bp, - strand
From NCBI annotation of GRCm38

  52143 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32402  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Nup133

Human
homologs
Human Homolog NUP133, nucleoporin 133kDa
NCBI Gene ID 55746
neXtProt AC  NX_Q8WUM0
Human Synonyms  hNUP133
Human Chr (Location)  1q42.13; chr1:229441297-229508341 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Chemically induced (ENU)(1) Gene trapped(9) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for an ENU-induced allele exhibit embryonic lethality prior to E10.5, abnormal somitogenesis, pericardial edema, growth retardation, and abnormal neural development.
 
Interactions
Nup133 interacts with 283 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process mRNA export from nucleus, mRNA transport, ...
Component chromosome, chromosome, centromeric region, ...
Function nucleocytoplasmic transporter activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (31)    Tissues (14)   
Theiler Stages: 7, 11, 13, 15
Assay TypeResults
Immunohistochemistry 2
RNA in situ 6
In situ reporter (knock in) 20
Western blot 3
cDNA source data(123)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(124) cDNA(123) Other(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000039509 (Evidence)
Entrez Gene234865 (Evidence)
UniGene267812
DFCITC1574116, TC1603770, TC1622046, TC1738961
DoTSDT.101736504, DT.531689, DT.91334372, DT.91425357
NIA Mouse Gene IndexU030384, U320416
Consensus CDS ProjectCCDS22765.1
International Mouse Knockout Project StatusNup133
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 234865 NCBI Gene Model | MGI Sequence Detail 52143 C57BL/6J ±  kb
transcript NM_172288 RefSeq | MGI Sequence Detail 5808 C57BL/6 
polypeptide Q8R0G9 UniProt | EBI | MGI Sequence Detail 1155 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(669 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007187 Nucleoporin, Nup133/Nup155-like, C-terminal
InterPro IPR014908 Nucleoporin, Nup133/Nup155-like, N-terminal
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000011507 nuclear pore complex protein Nup133
Graphical View of Protein Domain Structure
References (Earliest) J:114003 Belgareh N, et al., An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells. J Cell Biol. 2001 Sep 17;154(6):1147-60
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(30)
Other
accession IDs
MGI:3578197

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory