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Adamts18
Gene Detail
 Symbol
Name
ID
Adamts18
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18
MGI:2442600
Synonyms E130314N14Rik
Feature Type protein coding gene
Genetic Map
Chromosome 8
59.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:113698137-113848839 bp, - strand
From NCBI annotation of GRCm38

  150703 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:65241  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Adamts18

Human
homologs
Human Homolog ADAMTS18, ADAM metallopeptidase with thrombospondin type 1 motif, 18
NCBI Gene ID 170692
neXtProt AC  NX_Q8TE60
Human Synonyms  ADAMTS21, KNO2, MMCAT
Human Chr (Location)  16q23; chr16:77282128-77435114 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ADAMTS18
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a floxed allele exhibit some fertility defects.
 
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process eye development, negative regulation of platelet aggregation, ...
Component extracellular matrix, extracellular region, ...
Function hydrolase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (76)    Tissues (7)    Images (22)
Theiler Stages: 11, 23
Assay TypeResults
RNA in situ 75
RT-PCR 1
cDNA source data(33)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(34) cDNA(33) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000053399 (Evidence)
Entrez Gene208936 (Evidence)
UniGene167471
DFCITC1586753, TC1590926, TC1592631, TC1626680, TC1628970
DoTSDT.101362468, DT.87032140, DT.94122479, DT.94167399, DT.94273175
NIA Mouse Gene IndexU131701
EC3.4.24.-
Consensus CDS ProjectCCDS40485.1
International Mouse Knockout Project StatusAdamts18
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 208936 NCBI Gene Model | MGI Sequence Detail 150703 C57BL/6J ±  kb
transcript NM_172466 RefSeq | MGI Sequence Detail 4855 C57BL/6 
polypeptide Q4VC17 UniProt | EBI | MGI Sequence Detail 1219 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(20) UniProt(5)
Polymorphisms SNPs within 2kb(1264 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010294 ADAM-TS Spacer 1
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR001590 Peptidase M12B, ADAM/reprolysin
InterPro IPR013273 Peptidase M12B, ADAM-TS
InterPro IPR002870 Peptidase M12B, propeptide
InterPro IPR010909 PLAC
InterPro IPR000884 Thrombospondin, type 1 repeat
Protein Ontology PR:000032093 A disintegrin and metalloproteinase with thrombospondin motifs 18
Graphical View of Protein Domain Structure
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:182590 Wang J, et al., Identification of a thrombin cleavage site and a short form of ADAMTS-18. Biochem Biophys Res Commun. 2012 Mar 23;419(4):692-7
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory