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Adamts18 Gene Detail
Summary
  • Symbol
    Adamts18
  • Name
    a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18
  • Synonyms
    E130314N14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442600
    NCBI Gene: 208936
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:113697126-113848738 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      151613 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 59.65 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    ADAMTS18, ADAM metallopeptidase with thrombospondin type 1 motif 18
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ADAMTS18, ADAM metallopeptidase with thrombospondin type 1 motif 18
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ADAMTS21, KNO2, MMCAT
  • Links
    NCBI Gene ID: 170692
    neXtProt AC: NX_Q8TE60
    UniProt: Q8TE60

  • Chr Location
    16q23.1; chr16:77282128-77435114 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 3 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a floxed allele exhibit some fertility defects. Mice homozygous for a null allele exhibit growth and eye defects and increased susceptibility to chemically induced tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000061750 VEGA Gene Model | MGI Sequence Detail 151613 C57BL/6J ±  kb
    transcript OTTMUST00000150697 VEGA | MGI Sequence Detail 5642 Not Applicable  
    polypeptide OTTMUSP00000078148 VEGA | MGI Sequence Detail 1219 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1267 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 34
      Primer pair 1
      Other 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 9
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:258265 Zhu R, et al., A Disintegrin and Metalloproteinase with Thrombospondin Motifs 18 Deficiency Leads to Visceral Adiposity and Associated Metabolic Syndrome in Mice. Am J Pathol. 2018 Feb;188(2):461-473

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory