Mroh1 Gene Detail

Summary

• Symbol
  Mroh1
• Name
  maestro heat-like repeat family member 1
• Synonyms
  D330001F17Rik, Heatr7a, mKIAA1833

• Feature Type
  protein coding gene
• IDs
  MGI:2442558
  NCBI Gene: 223658
• Alliance
  gene page
• Transcription Start Sites
  3 TSS

Location &
Maps

• Sequence Map
  Chr15:76380438-76453039 bp, + strand
• From NCBI annotation of GRCm38
  

  View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 15, 35.80 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  416 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442558	protein coding gene	Chr15:76380261-76453039 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021991	protein coding gene	Chr15:76452886-76527776 (+)
A/J	MGP_AJ_G0021949	protein coding gene	Chr15:73669377-73742057 (+)
AKR/J	MGP_AKRJ_G0021932	protein coding gene	Chr15:75669735-75742024 (+)
BALB/cJ	MGP_BALBcJ_G0021958	protein coding gene	Chr15:73696889-73769750 (+)
C3H/HeJ	MGP_C3HHeJ_G0021730	protein coding gene	Chr15:75715098-75789498 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022398	protein coding gene	Chr15:79320846-79394497 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019927	protein coding gene	Chr15:70328676-70403630 (+)
CAST/EiJ	MGP_CASTEiJ_G0021249	protein coding gene	Chr15:76511717-76591705 (+)
CBA/J	MGP_CBAJ_G0021697	protein coding gene	Chr15:81819325-81897872 (+)
DBA/2J	MGP_DBA2J_G0021822	protein coding gene	Chr15:73203724-73279119 (+)
FVB/NJ	MGP_FVBNJ_G0021802	protein coding gene	Chr15:72258855-72332648 (+)
LP/J	MGP_LPJ_G0021893	protein coding gene	Chr15:76546530-76626135 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021827	protein coding gene	Chr15:87151472-87233111 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022418	protein coding gene	Chr15:75911098-75993542 (+)
PWK/PhJ	MGP_PWKPhJ_G0020990	protein coding gene	Chr15:73363335-73441194 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020830	protein coding gene	Chr15:75631416-75708853 (+)
WSB/EiJ	MGP_WSBEiJ_G0021301	protein coding gene	Chr15:76016250-76097479 (+)

Homology

• Human Ortholog
  MROH1, maestro heat like repeat family member 1

• Vertebrate Orthologs
  8

• Human Ortholog
  MROH1, maestro heat like repeat family member 1
  Orthology source: HomoloGene, HGNC
• Synonyms
  HEATR7A
• Links
  HGNC:26958

  NCBI Gene ID: 727957

  neXtProt AC: NX_Q8NDA8

  UniProt: Q8NDA8

  
  
• Chr Location
  8q24.3; chr8:144148016-144261940 (+)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 44882
  1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: MROH1
• Gene Tree
  Mroh1
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  26 phenotype references
  

• All Mutations and Alleles
  7
• Chemically induced (other)
  3
• Gene trapped
  1
• Radiation induced
  2
• Targeted
  1
• Genomic Mutations
  5 involving Mroh1
• Incidental Mutations
  APF
• Find Mice (IMSR)
  36 strains or lines available

Gene Ontology
(GO)
Classifications

• External Resources
  FuncBase

Expression

• cDNA Data
  103

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase mroh1

Interactions

• Mroh1 interacts with 302 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

Sequences &
Gene Models

• All Sequences
  122
• RefSeq
  34
• UniProt
  6
• CCDS
  CCDS49651.1, CCDS49652.1
• UniGene
  123240

• Ensembl
  ENSMUSG00000022558 (Evidence)
• NCBI Gene
  223658

Representative Sequences			Length	Strain/Species
genomic	223658	NCBI Gene Model | MGI Sequence Detail	72602	C57BL/6J
transcript	NM_175457	RefSeq | MGI Sequence Detail	5269	C57BL/6
polypeptide	NP_780666	RefSeq | MGI Sequence Detail	1640	C57BL/6

Protein
Information

• UniProt
  6 Sequences
• InterPro Domains
  IPR011989 Armadillo-like helical
  IPR016024 Armadillo-type fold
  IPR000357 HEAT repeat
  IPR021133 HEAT, type 2

Molecular
Reagents

• All nucleic 103

  cDNA 103

  
  

  Microarray probesets 6

References

• Summaries
  All 44

  Diseases 1

  Phenotypes 26
• Earliest
  J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
• Latest
  J:233611 Hirata A, et al., Homeobox family Hoxc localization during murine palate formation. Congenit Anom (Kyoto). 2016 Jul;56(4):172-9

TSS for Mroh1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131789	Chr15:76380468-76380479 (+)	36 bp
Tssr131790	Chr15:76380492-76380542 (+)	79 bp
Tssr131791	Chr15:76441064-76441069 (+)	60,629 bp