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Itpkc
Gene Detail
 Symbol
Name
ID
Itpkc
inositol 1,4,5-trisphosphate 3-kinase C
MGI:2442554
Synonyms 9130023N17Rik
Feature Type protein coding gene
Genetic Map
Chromosome 7
15.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:27207172-27228628 bp, - strand
From VEGA annotation of GRCm38

  21457 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11868  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Itpkc

Human
homologs
Human Homolog ITPKC, inositol-trisphosphate 3-kinase C
NCBI Gene ID 80271
neXtProt AC  NX_Q96DU7
Human Synonyms  IP3-3KC, IP3KC
Human Chr (Location)  19q13.1; chr19:40716980-40740860 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ITPKC
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(4) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
No overt phenotype reported. Thymocyte development was normal in homozygous null mice.
 
Interactions
Itpkc interacts with 164 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process phosphorylation
Component cytoplasm, nucleus
Function ATP binding, calmodulin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000023456 (Evidence)
Ensembl Gene ModelENSMUSG00000003752 (Evidence)
Entrez Gene233011 (Evidence)
DFCITC1578358, TC1603726, TC1621038
NIA Mouse Gene IndexU109139
EC2.7.1.127
Consensus CDS ProjectCCDS21015.1
International Mouse Knockout Project StatusItpkc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023456 VEGA Gene Model | MGI Sequence Detail 21457 C57BL/6J ±  kb
transcript OTTMUST00000057030 VEGA | MGI Sequence Detail 3247 Not Applicable 
polypeptide OTTMUSP00000027470 VEGA | MGI Sequence Detail 678 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(59 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005522 Inositol polyphosphate kinase
Protein Ontology PR:000009157 inositol-trisphosphate 3-kinase C
References (Earliest) J:86698 Dewaste V, et al., Cloning and expression of a cDNA encoding human inositol 1,4,5-trisphosphate 3-kinase C. Biochem J. 2000 Dec 1;352 Pt 2:343-51
(Latest) J:142754 Hansen GM, et al., Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. 2008 Oct;18(10):1670-9
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory