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Itpkc Gene Detail
Summary
  • Symbol
    Itpkc
  • Name
    inositol 1,4,5-trisphosphate 3-kinase C
  • Synonyms
    9130023N17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442554
    NCBI Gene: 233011
Location & Maps
more
  • Sequence Map
    Chr7:27207172-27228661 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21490 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 15.85 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ITPKC, inositol-trisphosphate 3-kinase C
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ITPKC, inositol-trisphosphate 3-kinase C
    Orthology source: HGNC, HomoloGene
  • Synonyms
    IP3-3KC, IP3KC
  • Links
    NCBI Gene ID: 80271
    neXtProt AC: NX_Q96DU7

  • Chr Location
    19q13.1; chr19:40716980-40740860 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human ITPKC associations

Human Disease Mouse Models
       Kawasaki Disease   OMIM: 611775
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    8 phenotype references
  • All Mutations and Alleles
    7
  • Gene trapped
    5
  • Targeted
    2
  • Incidental Mutations
No overt phenotype reported. Thymocyte development was normal in homozygous null mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023456 VEGA Gene Model | MGI Sequence Detail 21490 C57BL/6J ±  kb
transcript OTTMUST00000057030 VEGA | MGI Sequence Detail 3247 Not Applicable  
polypeptide OTTMUSP00000027470 VEGA | MGI Sequence Detail 678 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    59 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 3
References
more
  • Summaries
    All 29
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:86698 Dewaste V, et al., Cloning and expression of a cDNA encoding human inositol 1,4,5-trisphosphate 3-kinase C. Biochem J. 2000 Dec 1;352 Pt 2:343-51
  • Latest
    J:224530 Dietrich JE, et al., Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages. EMBO Rep. 2015 Aug;16(8):1005-21

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory