Eml5 MGI Mouse Gene Detail - MGI:2442513 - echinoderm microtubule associated protein like 5

Symbol

Eml5
Name

echinoderm microtubule associated protein like 5
Synonyms

C130068M19Rik

Feature Type

protein coding gene
IDs

MGI:2442513
NCBI Gene: 319670
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr12:98753064-98867743 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 49.88 cM
Mapping Data

1 experiment

SNPs within 2kb

5496 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442513	protein coding gene	Chr12:98752863-98867770 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020009	protein coding gene	Chr12:100190647-100309845 (-)
A/J	MGP_AJ_G0019964	protein coding gene	Chr12:96424001-96546329 (-)
AKR/J	MGP_AKRJ_G0019940	protein coding gene	Chr12:99028955-99151475 (-)
BALB/cJ	MGP_BALBcJ_G0019950	protein coding gene	Chr12:96755370-96882712 (-)
C3H/HeJ	MGP_C3HHeJ_G0019752	protein coding gene	Chr12:99580486-99694207 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020399	protein coding gene	Chr12:103237317-103370541 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018013	protein coding gene	Chr12:93391063-93510031 (-)
CAST/EiJ	MGP_CASTEiJ_G0019298	protein coding gene	Chr12:94631589-94755190 (-)
CBA/J	MGP_CBAJ_G0019724	protein coding gene	Chr12:107076694-107204104 (-)
DBA/2J	MGP_DBA2J_G0019835	protein coding gene	Chr12:95848250-95964583 (-)
FVB/NJ	MGP_FVBNJ_G0019824	protein coding gene	Chr12:94567029-94683121 (-)
LP/J	MGP_LPJ_G0019911	protein coding gene	Chr12:100018583-100142771 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019866	protein coding gene	Chr12:110749959-110889099 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020428	protein coding gene	Chr12:98594957-98714128 (-)
PWK/PhJ	MGP_PWKPhJ_G0019062	protein coding gene	Chr12:90463697-90583088 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018858	protein coding gene	Chr12:92757893-92878180 (-)
WSB/EiJ	MGP_WSBEiJ_G0019352	protein coding gene	Chr12:99426834-99545626 (-)

Human Ortholog

EML5, EMAP like 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EML5, EMAP like 5
Synonyms

EMAP-2, EMAP-5, FAP16
Links

HGNC:18197

NCBI Gene ID: 161436

UniProt: Q05BV3
Chr Location

14q31.3; chr14:88612431-88792953 (-) GRCh38

MGI Vertebrate Homology

Eml5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EML5
Gene Tree

Eml5

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Phenotype Summary

5 phenotype references

All Mutations and Alleles

6
Chemically induced (other)

1
Gene trapped

1
Targeted

4
Genomic Mutations

1 involving Eml5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

92 strains or lines available

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All GO Annotations

6
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

10
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase eml5

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All Sequences

90
RefSeq

34
UniProt

6
CCDS

CCDS36519.1

Ensembl

ENSMUSG00000051166 (Evidence)
NCBI Gene

319670

			Length	Strain/Species	Flank
genomic	ENSMUSG00000051166	Ensembl Gene Model \| MGI Sequence Detail	114680	C57BL/6J	± kb
transcript	ENSMUST00000223282	Ensembl \| MGI Sequence Detail	7595	Not Applicable
polypeptide	ENSMUSP00000152709	Ensembl \| MGI Sequence Detail	1977	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000007060 echinoderm microtubule-associated protein-like 5

(term hierarchy)
InterPro Domains

IPR005108 HELP motif

IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily

IPR001680 WD40 repeat

IPR019775 WD40 repeat, conserved site

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

IPR050630 WD repeat Echinoderm Microtubule-associated Protein-like

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All nucleic 11

cDNA 11

Microarray probesets 9

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MGI:2446158

Summaries

All 28

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 5
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:156036 Schilling K, et al., The treasury of the commons: making use of public gene expression resources to better characterize the molecular diversity of inhibitory interneurons in the cerebellar cortex. Cerebellum. 2009 Dec;8(4):477-89

TSS for Eml5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr117284	Chr12:98867737-98867751 (-)	-1 bp
Tssr117283	Chr12:98867674-98867731 (-)	40 bp
Tssr117282	Chr12:98867570-98867581 (-)	167 bp
Tssr117281	Chr12:98867523-98867534 (-)	214 bp
Tssr117280	Chr12:98844016-98844020 (-)	23,725 bp
Tssr117279	Chr12:98788494-98788497 (-)	79,247 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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