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Dars2
Gene Detail
 Symbol
Name
ID
Dars2
aspartyl-tRNA synthetase 2 (mitochondrial)
MGI:2442510
Synonyms 5830468K18Rik
Feature Type protein coding gene
Genetic Map
Chromosome 1
69.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:161040601-161070658 bp, - strand
From VEGA annotation of GRCm38

  30058 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7093  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Dars2

Human
homologs
Human Homolog DARS2, aspartyl-tRNA synthetase 2, mitochondrial
NCBI Gene ID 55157
neXtProt AC  NX_Q6PI48
Human Synonyms  ASPRS, LBSL, MT-ASPRS
Human Chr (Location)  1q25.1; chr1:173824581-173858544 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human DARS2
Alleles
and
phenotypes
All alleles(5) : Gene trapped(3) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process translation, tRNA aminoacylation, ...
Component cytoplasm, mitochondrion, ...
Function aminoacyl-tRNA ligase activity, aspartate-tRNA(Asn) ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Images (12)
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(65)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(65) cDNA(65)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000031015 (Evidence)
Ensembl Gene ModelENSMUSG00000026709 (Evidence)
Entrez Gene226539 (Evidence)
UniGene28125
DFCITC1575661, TC1595714, TC1607213, TC1608693
DoTSDT.101389495, DT.101389497, DT.101736421, DT.526425, DT.87053238, DT.94141921
NIA Mouse Gene IndexU021953
EC6.1.1.12
Consensus CDS ProjectCCDS15413.1
International Mouse Knockout Project StatusDars2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031015 VEGA Gene Model | MGI Sequence Detail 30058 C57BL/6J ±  kb
transcript OTTMUST00000076822 VEGA | MGI Sequence Detail 3619 Not Applicable 
polypeptide OTTMUSP00000040500 VEGA | MGI Sequence Detail 653 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(6) UniProt(3)
Polymorphisms SNPs within 2kb(378 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006195 Aminoacyl-tRNA synthetase, class II
InterPro IPR004364 Aminoacyl-tRNA synthetase, class II (D/K/N)
InterPro IPR018150 Aminoacyl-tRNA synthetase, class II (D/K/N)-like
InterPro IPR004524 Aspartate-tRNA ligase, class IIb, bacterial/mitochondrial-type
InterPro IPR002312 Aspartyl/Asparaginyl-tRNA synthetase, class IIb
InterPro IPR004115 GAD domain
InterPro IPR012340 Nucleic acid-binding, OB-fold
InterPro IPR004365 Nucleic acid binding, OB-fold, tRNA/helicase-type
Protein Ontology PR:000006282 aspartate--tRNA ligase, mitochondrial
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(30)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory