Dars2
Gene Detail

Symbol Name ID

Dars2 aspartyl-tRNA synthetase 2 (mitochondrial) MGI:2442510

Synonyms

5830468K18Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 1

69.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:161040601-161070658 bp, - strand From VEGA annotation of GRCm38   30058 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7093  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Dars2

Human homologs

Human Homolog		DARS2, aspartyl-tRNA synthetase 2, mitochondrial
NCBI Gene ID		55157
neXtProt AC		NX_Q6PI48
Human Synonyms		ASPRS, LBSL, MT-ASPRS, RP3-383J4.2
Human Chr (Location)		1q25.1; chr1:173793797-173827682 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human DARS2

Alleles and phenotypes

All alleles(5) : Targeted(2) Gene trapped(3)

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	translation, tRNA aminoacylation, ...
Component	cytoplasm, mitochondrion, ...
Function	aminoacyl-tRNA ligase activity, aspartate-tRNA(Asn) ligase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Images (12)
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(65)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(65) cDNA(65)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000031015 (Evidence)
Ensembl Gene Model	ENSMUSG00000026709 (Evidence)
Entrez Gene	226539 (Evidence)
UniGene	28125
DFCI	TC1575661, TC1595714, TC1607213, TC1608693
DoTS	DT.101389495, DT.101389497, DT.101736421, DT.526425, DT.87053238, DT.94141921
NIA Mouse Gene Index	U021953
EC	6.1.1.12
Consensus CDS Project	CCDS15413.1
International Mouse Knockout Project Status	Dars2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031015	VEGA Gene Model | MGI Sequence Detail	30058	C57BL/6J
transcript	OTTMUST00000076822	VEGA | MGI Sequence Detail	3619	Not Applicable
polypeptide	OTTMUSP00000040500	VEGA | MGI Sequence Detail	653	Not Applicable

All sequences(59) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(221 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006195	Aminoacyl-tRNA synthetase, class II
InterPro	IPR004364	Aminoacyl-tRNA synthetase, class II (D/K/N)
InterPro	IPR018150	Aminoacyl-tRNA synthetase, class II (D/K/N)-like
InterPro	IPR004524	Aspartate-tRNA ligase, class IIb, bacterial/mitochondrial-type
InterPro	IPR002312	Aspartyl/Asparaginyl-tRNA synthetase, class IIb
InterPro	IPR004115	GAD domain
InterPro	IPR012340	Nucleic acid-binding, OB-fold
InterPro	IPR016027	Nucleic acid-binding, OB-fold-like
InterPro	IPR004365	Nucleic acid binding, OB-fold, tRNA/helicase-type
Protein Ontology	PR:000006282	aspartyl-tRNA synthetase, mitochondrial

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(30)