About   Help   FAQ
Dars2 Gene Detail
Summary
  • Symbol
    Dars2
  • Name
    aspartyl-tRNA synthetase 2 (mitochondrial)
  • Synonyms
    5830468K18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442510
    NCBI Gene: 226539
Location & Maps
more
  • Sequence Map
    Chr1:161040601-161070658 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      30058 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 69.75 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DARS2, aspartyl-tRNA synthetase 2, mitochondrial
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DARS2, aspartyl-tRNA synthetase 2, mitochondrial
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ASPRS, LBSL, MT-ASPRS
  • Links
    NCBI Gene ID: 55157
    neXtProt AC: NX_Q6PI48

  • Chr Location
    1q25.1; chr1:173824645-173858544 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 7093
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: DARS2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human DARS2 associations

Human Disease Mouse Models
       Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate Elevation; LBSL   OMIM: 611105
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    2
  • Gene trapped
    3
  • Targeted
    2
  • Genomic Mutations
    2 involving Dars2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031015 VEGA Gene Model | MGI Sequence Detail 30058 C57BL/6J ±  kb
transcript OTTMUST00000076822 VEGA | MGI Sequence Detail 3619 Not Applicable  
polypeptide OTTMUSP00000040500 VEGA | MGI Sequence Detail 653 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    378 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000006282 aspartate--tRNA ligase, mitochondrial
  • EC
  • InterPro Domains
    IPR006195 Aminoacyl-tRNA synthetase, class II
    IPR004364 Aminoacyl-tRNA synthetase, class II (D/K/N)
    IPR018150 Aminoacyl-tRNA synthetase, class II (D/K/N)-like
    IPR004524 Aspartate-tRNA ligase, bacterial/mitochondrial-type
    IPR002312 Aspartyl/Asparaginyl-tRNA synthetase, class IIb
    IPR029351 GAD domain
    IPR004115 GAD-like domain
    IPR012340 Nucleic acid-binding, OB-fold
    IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
Molecular
Reagents
less
  • All nucleic 65
    cDNA 65

    Microarray probesets 2
References
more
  • Summaries
    All 28
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:234481 Seiferling D, et al., Loss of CLPP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt. EMBO Rep. 2016 Jul;17(7):953-64

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/20/2016
MGI 6.05
The Jackson Laboratory