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Dars2 Gene Detail
Summary
  • Symbol
    Dars2
  • Name
    aspartyl-tRNA synthetase 2 (mitochondrial)
  • Synonyms
    5830468K18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442510
    NCBI Gene: 226539
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:161040601-161070658 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 69.75 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    378 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442510
protein coding gene Chr1:161040601-161070660 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016647
protein coding gene Chr1:166291372-166325290 (-)
A/J MGP_AJ_G0016628
protein coding gene Chr1:159524831-159555537 (-)
AKR/J MGP_AKRJ_G0016594
protein coding gene Chr1:164392375-164423550 (-)
BALB/cJ MGP_BALBcJ_G0016589
protein coding gene Chr1:160065459-160096138 (-)
C3H/HeJ MGP_C3HHeJ_G0016413
protein coding gene Chr1:164593234-164623057 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017050
protein coding gene Chr1:171938188-171971185 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014759
protein coding gene Chr1:151641790-151673424 (-)
CAST/EiJ MGP_CASTEiJ_G0015993
protein coding gene Chr1:164203368-164237148 (-)
CBA/J MGP_CBAJ_G0016388
protein coding gene Chr1:178019720-178060508 (-)
DBA/2J MGP_DBA2J_G0016494
protein coding gene Chr1:158503179-158533523 (-)
FVB/NJ MGP_FVBNJ_G0016492
protein coding gene Chr1:156912927-156943614 (-)
LP/J MGP_LPJ_G0016565
protein coding gene Chr1:167381187-167412470 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016517
protein coding gene Chr1:185593536-185623510 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017086
protein coding gene Chr1:164211076-164241062 (-)
PWK/PhJ MGP_PWKPhJ_G0015779
protein coding gene Chr1:157659266-157690077 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015566
protein coding gene Chr1:163106117-163140515 (-)
WSB/EiJ MGP_WSBEiJ_G0016055
protein coding gene Chr1:164401853-164432967 (-)



Homology
more
  • Human Ortholog
    DARS2, aspartyl-tRNA synthetase 2, mitochondrial
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DARS2, aspartyl-tRNA synthetase 2, mitochondrial
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ASPRS, LBSL, MT-ASPRS
  • Links
    NCBI Gene ID: 55157
    neXtProt AC: NX_Q6PI48
    UniProt: Q6PI48

  • Chr Location
    1q25.1; chr1:173824659-173858544 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7093
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DARS2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026709 Ensembl Gene Model | MGI Sequence Detail 30058 C57BL/6J ±  kb
transcript ENSMUST00000035430 Ensembl | MGI Sequence Detail 3619 Not Applicable  
polypeptide ENSMUSP00000041851 Ensembl | MGI Sequence Detail 653 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 66
    cDNA 66

    Microarray probesets 2
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:251667 Aradjanski M, et al., DARS2 protects against neuroinflammation and apoptotic neuronal loss, but is dispensable for myelin producing cells. Hum Mol Genet. 2017 Nov 01;26(21):4181-4189

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory