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Dars2
Gene Detail
Symbol

Name
ID
Dars2
aspartyl-tRNA synthetase 2 (mitochondrial)
MGI:2442510
Synonyms
5830468K18Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 1
69.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:161040601-161070658 bp, - strand
From VEGA annotation of GRCm38

  30058 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7093  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DARS2
Gene Tree: Dars2

Human
homologs
DARS2, aspartyl-tRNA synthetase 2, mitochondrial
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 55157
neXtProt AC: NX_Q6PI48

Human Synonyms: ASPRS, LBSL, MT-ASPRS

Human Chr (Location): 1q25.1; chr1:173824645-173858544 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human DARS2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(3) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Dars2 interacts with 153 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process translation, tRNA aminoacylation, ...
Component cytoplasm, mitochondrion, ...
Function aminoacyl-tRNA ligase activity, aspartate-tRNA(Asn) ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(65)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase dars2    NEW 
Molecular
reagents
All nucleic(65) cDNA(65)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000031015 (Evidence)
Ensembl Gene Model ENSMUSG00000026709 (Evidence)
Entrez Gene 226539 (Evidence)
UniGene 28125
DFCI TC1575661, TC1595714, TC1607213, TC1608693
DoTS DT.101389495, DT.101389497, DT.101736421, DT.526425, DT.87053238, DT.94141921
NIA Mouse Gene Index U021953
EC 6.1.1.12
Consensus CDS Project CCDS15413.1
International Mouse Phenotyping Consortium Status Dars2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031015 VEGA Gene Model | MGI Sequence Detail 30058 C57BL/6J ±  kb
transcript OTTMUST00000076822 VEGA | MGI Sequence Detail 3619 Not Applicable 
polypeptide OTTMUSP00000040500 VEGA | MGI Sequence Detail 653 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(378 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006195 Aminoacyl-tRNA synthetase, class II
InterPro IPR004364 Aminoacyl-tRNA synthetase, class II (D/K/N)
InterPro IPR018150 Aminoacyl-tRNA synthetase, class II (D/K/N)-like
InterPro IPR004524 Aspartate-tRNA ligase, class IIb, bacterial/mitochondrial-type
InterPro IPR002312 Aspartyl/Asparaginyl-tRNA synthetase, class IIb
InterPro IPR004115 GAD domain
InterPro IPR012340 Nucleic acid-binding, OB-fold
InterPro IPR004365 Nucleic acid binding, OB-fold, tRNA/helicase-type
Protein Ontology PR:000006282 aspartate--tRNA ligase, mitochondrial
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:210635 Dogan SA, et al., Tissue-specific loss of DARS2 activates stress responses independently of respiratory chain deficiency in the heart. Cell Metab. 2014 Mar 4;19(3):458-69
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory