Arhgef4
Gene Detail

Symbol Name ID

Arhgef4 Rho guanine nucleotide exchange factor (GEF) 4 MGI:2442507

Synonyms

9330140K16Rik, Asef

Feature Type

protein coding gene

Genetic Map

Chromosome 1

13.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:34721924-34813309 bp, + strand From VEGA annotation of GRCm38   91386 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:49414  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Arhgef4

Human homologs

Human Homolog		ARHGEF4, Rho guanine nucleotide exchange factor (GEF) 4
NCBI Gene ID		50649
neXtProt AC		NX_Q9NR80
Human Synonyms		ASEF, ASEF1, GEF4, STM6
Human Chr (Location)		2q22; chr2:131674224-131804836 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a knock-out allele exhibit decreased angiogenesis, vascular endothelial cell migration, tumor growth, and tumor vascularization.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	filopodium assembly, intracellular signal transduction, ...
Component	cytoplasm
Function	guanyl-nucleotide exchange factor activity, phospholipid binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(36)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(36) cDNA(36)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000033276 (Evidence)
Ensembl Gene Model	ENSMUSG00000037509 (Evidence)
Entrez Gene	226970 (Evidence)
UniGene	41604
DFCI	TC1581338, TC1611873
Consensus CDS Project	CCDS14872.1
International Mouse Knockout Project Status	Arhgef4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033276	VEGA Gene Model | MGI Sequence Detail	91386	C57BL/6J
transcript	OTTMUST00000083453	VEGA | MGI Sequence Detail	6219	Not Applicable
polypeptide	OTTMUSP00000044854	VEGA | MGI Sequence Detail	1716	Not Applicable

All sequences(56) RefSeq(2) UniProt(8)

Polymorphisms

SNPs(39 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000219	Dbl homology (DH) domain
InterPro	IPR001331	Guanine-nucleotide dissociation stimulator, CDC24, conserved site
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR001452	Src homology-3 domain
Protein Ontology	PR:000004257	rho guanine nucleotide exchange factor 4

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:188394 Kang P, et al., Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis. Neuron. 2012 Apr 12;74(1):79-94
All references(30)

Other accession IDs

MGI:3642632