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Arhgef4
Gene Detail
 Symbol
Name
ID
Arhgef4
Rho guanine nucleotide exchange factor (GEF) 4
MGI:2442507
Synonyms 9330140K16Rik, Asef
Feature Type protein coding gene
Genetic Map
Chromosome 1
13.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:34678188-34813309 bp, + strand
From VEGA annotation of GRCm38

  135122 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49414  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Arhgef4

Human
homologs
Human Homolog ARHGEF4, Rho guanine nucleotide exchange factor (GEF) 4
NCBI Gene ID 50649
neXtProt AC  NX_Q9NR80
Human Synonyms  ASEF, ASEF1, GEF4, STM6
Human Chr (Location)  2q22; chr2:130836916-131047253 (+)  GRCh38
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
 
Mice homozygous for a knock-out allele exhibit decreased angiogenesis, vascular endothelial cell migration, tumor growth, and tumor vascularization.
 
Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process filopodium assembly, intracellular signal transduction, ...
Component cytoplasm
Function guanyl-nucleotide exchange factor activity, protein domain specific binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(37)
External Resources: GEO   ArrayExpress
Molecular
reagents
All nucleic(37) cDNA(37)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000033276 (Evidence)
Ensembl Gene ModelENSMUSG00000037509 (Evidence)
Entrez Gene226970 (Evidence)
UniGene41604
DFCITC1581338, TC1611873
Consensus CDS ProjectCCDS14872.1
International Mouse Knockout Project StatusArhgef4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033276 VEGA Gene Model | MGI Sequence Detail 135122 C57BL/6J ±  kb
transcript OTTMUST00000083453 VEGA | MGI Sequence Detail 6514 Not Applicable 
polypeptide OTTMUSP00000044854 VEGA | MGI Sequence Detail 1855 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(2) UniProt(8)
Polymorphisms SNPs within 2kb(925 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000004257 rho guanine nucleotide exchange factor 4
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:188394 Kang P, et al., Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis. Neuron. 2012 Apr 12;74(1):79-94
All references(30)
Other
accession IDs
MGI:3642632

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory