Arhgef4 MGI Mouse Gene Detail - MGI:2442507 - Rho guanine nucleotide exchange factor 4

Symbol

Arhgef4
Name

Rho guanine nucleotide exchange factor 4
Synonyms

9330140K16Rik, Asef, C230030N03Rik

Feature Type

protein coding gene
IDs

MGI:2442507
NCBI Gene: 226970
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr1:34717263-34851819 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 13.34 cM
Mapping Data

3 experiments

SNPs within 2kb

914 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442507	protein coding gene	Chr1:34717263-34852390 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0015914	protein coding gene	Chr1:33100283-33247195 (+)
A/J	MGP_AJ_G0015898	protein coding gene	Chr1:32273317-32410020 (+)
AKR/J	MGP_AKRJ_G0015853	protein coding gene	Chr1:32683424-32822633 (+)
BALB/cJ	MGP_BALBcJ_G0015852	protein coding gene	Chr1:31949839-32085161 (+)
C3H/HeJ	MGP_C3HHeJ_G0015685	protein coding gene	Chr1:32892464-33031724 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016305	protein coding gene	Chr1:34602396-34750490 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014027	protein coding gene	Chr1:29412647-29547938 (+)
CAST/EiJ	MGP_CASTEiJ_G0015266	protein coding gene	Chr1:32767923-32908569 (+)
CBA/J	MGP_CBAJ_G0015657	protein coding gene	Chr1:35561594-35695364 (+)
DBA/2J	MGP_DBA2J_G0015758	protein coding gene	Chr1:31631340-31765967 (+)
FVB/NJ	MGP_FVBNJ_G0015760	protein coding gene	Chr1:31160203-31296615 (+)
LP/J	MGP_LPJ_G0015828	protein coding gene	Chr1:33438606-33587976 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015780	protein coding gene	Chr1:37809550-37949870 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016352	protein coding gene	Chr1:32688310-32831298 (+)
PWK/PhJ	MGP_PWKPhJ_G0015049	protein coding gene	Chr1:31358559-31496487 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014831	protein coding gene	Chr1:32676283-32808758 (+)
WSB/EiJ	MGP_WSBEiJ_G0015328	protein coding gene	Chr1:32673349-32812576 (+)

Human Ortholog

ARHGEF4, Rho guanine nucleotide exchange factor 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARHGEF4, Rho guanine nucleotide exchange factor 4
Synonyms

ASEF, ASEF1, GEF4, SMIM39, STM6
Links

HGNC:684

NCBI Gene ID: 50649

neXtProt AC: NX_Q9NR80

UniProt: Q9NR80
Chr Location

2q21.1; chr2:130836914-131047263 (+) GRCh38

MGI Vertebrate Homology

Arhgef4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ARHGEF4
Gene Tree

Arhgef4

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Phenotype Summary

17 phenotypes from 2 alleles in 3 genetic backgrounds
6 phenotypes from multigenic genotypes
2 images
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Targeted

3
Genomic Mutations

1 involving Arhgef4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

74 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased angiogenesis, vascular endothelial cell migration, tumor growth, and tumor vascularization.

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All GO Annotations

10
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

788
Tissues

16
cDNA Data

43
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ARHGEF4

Xenbase arhgef4

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All Sequences

63
RefSeq

4
UniProt

9
CCDS

CCDS14872.1, CCDS87817.1

Ensembl

ENSMUSG00000037509 (Evidence)
NCBI Gene

226970

			Length	Strain/Species	Flank
genomic	226970	NCBI Gene Model \| MGI Sequence Detail	134557	C57BL/6J	± kb
transcript	NM_001368773	RefSeq \| MGI Sequence Detail	6519	C57BL/6
polypeptide	Q7TNR9	UniProt \| EBI \| MGI Sequence Detail	484	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000004257 Rho guanine nucleotide exchange factor 4

(term hierarchy)
InterPro Domains

IPR000219 Dbl homology (DH) domain

IPR035899 Dbl homology (DH) domain superfamily

IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

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All nucleic 43

cDNA 43

Microarray probesets 4

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MGI:3045297, MGI:3642632

Summaries

All 38

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 12
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:298968 Yoo KS, et al., Rho Guanine Nucleotide Exchange Factor 4 (Arhgef4) Deficiency Enhances Spatial and Object Recognition Memory. Exp Neurobiol. 2020 Oct 31;29(5):334-343

TSS for Arhgef4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6230	Chr1:34717230-34717256 (+)	-20 bp
Tssr6231	Chr1:34717257-34717294 (+)	13 bp
Tssr6232	Chr1:34736626-34736632 (+)	19,366 bp
Tssr6233	Chr1:34789665-34789733 (+)	72,436 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23