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Arhgef4 Gene Detail
Summary
  • Symbol
    Arhgef4
  • Name
    Rho guanine nucleotide exchange factor (GEF) 4
  • Synonyms
    9330140K16Rik, Asef
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442507
    NCBI Gene: 226970
  • Gene Overview
    MyGene.info: ARHGEF4
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:34801722-34812754 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 13.34 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    70 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442507
protein coding gene Chr1:34678188-34813309 (.)
129S1/SvImJ MGP_129S1SvImJ_G0015914
protein coding gene Chr1:33100283-33247195 (+)
A/J MGP_AJ_G0015898
protein coding gene Chr1:32273317-32410020 (+)
AKR/J MGP_AKRJ_G0015853
protein coding gene Chr1:32683424-32822633 (+)
BALB/cJ MGP_BALBcJ_G0015852
protein coding gene Chr1:31949839-32085161 (+)
C3H/HeJ MGP_C3HHeJ_G0015685
protein coding gene Chr1:32892464-33031724 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016305
protein coding gene Chr1:34602396-34750490 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014027
protein coding gene Chr1:29412647-29547938 (+)
CAST/EiJ MGP_CASTEiJ_G0015266
protein coding gene Chr1:32767923-32908569 (+)
CBA/J MGP_CBAJ_G0015657
protein coding gene Chr1:35561594-35695364 (+)
DBA/2J MGP_DBA2J_G0015758
protein coding gene Chr1:31631340-31765967 (+)
FVB/NJ MGP_FVBNJ_G0015760
protein coding gene Chr1:31160203-31296615 (+)
LP/J MGP_LPJ_G0015828
protein coding gene Chr1:33438606-33587976 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015780
protein coding gene Chr1:37809550-37949870 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016352
protein coding gene Chr1:32688310-32831298 (+)
PWK/PhJ MGP_PWKPhJ_G0015049
protein coding gene Chr1:31358559-31496487 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014831
protein coding gene Chr1:32676283-32808758 (+)
WSB/EiJ MGP_WSBEiJ_G0015328
protein coding gene Chr1:32673349-32812576 (+)



Homology
more
  • Human Ortholog
    ARHGEF4, Rho guanine nucleotide exchange factor 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ARHGEF4, Rho guanine nucleotide exchange factor 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ASEF, ASEF1, GEF4, STM6
  • Links
    NCBI Gene ID: 50649
    neXtProt AC: NX_Q9NR80
    UniProt: Q9NR80

  • Chr Location
    2q21.1; chr2:130836916-131047253 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 2 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    2 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased angiogenesis, vascular endothelial cell migration, tumor growth, and tumor vascularization.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 226970 NCBI Gene Model | MGI Sequence Detail 11033 C57BL/6J ±  kb
    transcript NM_183019 RefSeq | MGI Sequence Detail 2738 C57BL/6  
    polypeptide Q7TNR9 UniProt | EBI | MGI Sequence Detail 484 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • InterPro Domains
      IPR000219 Dbl homology (DH) domain
      IPR035899 Dbl homology (DH) domain superfamily
      IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
      IPR011993 PH-like domain superfamily
      IPR001849 Pleckstrin homology domain
      IPR001452 SH3 domain
      IPR036028 SH3-like domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 39
      cDNA 39

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:3642632
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 10
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:237193 Chaboub LS, et al., Temporal Profiling of Astrocyte Precursors Reveals Parallel Roles for Asef during Development and after Injury. J Neurosci. 2016 Nov 23;36(47):11904-11917

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory