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Arhgef4 Gene Detail
Summary
  • Symbol
    Arhgef4
  • Name
    Rho guanine nucleotide exchange factor (GEF) 4
  • Synonyms
    9330140K16Rik, Asef
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442507
    NCBI Gene: 226970
Location & Maps
more
  • Sequence Map
    Chr1:34678188-34813309 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      135122 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ARHGEF4, Rho guanine nucleotide exchange factor 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ARHGEF4, Rho guanine nucleotide exchange factor 4
    Orthology source: HomoloGene
  • Synonyms
    ASEF, ASEF1, GEF4, STM6
  • Links
    NCBI Gene ID: 50649
    neXtProt AC: NX_Q9NR80

  • Chr Location
    2q22; chr2:130836916-131047253 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Arhgef4
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit decreased angiogenesis, vascular endothelial cell migration, tumor growth, and tumor vascularization.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033276 VEGA Gene Model | MGI Sequence Detail 135122 C57BL/6J ±  kb
transcript OTTMUST00000083453 VEGA | MGI Sequence Detail 6514 Not Applicable  
polypeptide OTTMUSP00000044854 VEGA | MGI Sequence Detail 1855 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    925 from dbSNP Build 137
Protein
Information
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  • UniProt
    8 Sequences
  • InterPro Domains
    IPR000219 Dbl homology (DH) domain
    IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
    IPR011993 PH domain-like
    IPR001849 Pleckstrin homology domain
    IPR001452 SH3 domain
Molecular
Reagents
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  • All nucleic 37
    cDNA 37

    Microarray probesets 3
Other
Accession IDs
less
MGI:3642632
References
more
  • Summaries
    All 26
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 7
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:188394 Kang P, et al., Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis. Neuron. 2012 Apr 12;74(1):79-94

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory