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Rnf157 Gene Detail
Summary
  • Symbol
    Rnf157
  • Name
    ring finger protein 157
  • Synonyms
    2610036E23Rik, A130073L17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442484
    NCBI Gene: 217340
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:116336353-116413032 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 81.17 cM, cytoband E2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    450 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442484
protein coding gene Chr11:116336345-116413032 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019425
protein coding gene Chr11:120441569-120520453 (-)
A/J MGP_AJ_G0019394
protein coding gene Chr11:115179266-115254077 (-)
AKR/J MGP_AKRJ_G0019364
protein coding gene Chr11:118607432-118691357 (-)
BALB/cJ MGP_BALBcJ_G0019368
protein coding gene Chr11:115588975-115662199 (-)
C3H/HeJ MGP_C3HHeJ_G0019174
protein coding gene Chr11:118961479-119036101 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019818
protein coding gene Chr11:124134373-124210865 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017441
protein coding gene Chr11:112190692-112261243 (-)
CAST/EiJ MGP_CASTEiJ_G0018729
protein coding gene Chr11:120328862-120409521 (-)
CBA/J MGP_CBAJ_G0019146
protein coding gene Chr11:129024476-129109568 (-)
DBA/2J MGP_DBA2J_G0019257
protein coding gene Chr11:114592549-114687032 (-)
FVB/NJ MGP_FVBNJ_G0019249
protein coding gene Chr11:114113578-114191674 (-)
LP/J MGP_LPJ_G0019327
protein coding gene Chr11:120823590-120905317 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019282
protein coding gene Chr11:128098370-128175706 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019856
protein coding gene Chr11:119270409-119346932 (-)
PWK/PhJ MGP_PWKPhJ_G0018493
protein coding gene Chr11:115929087-116002192 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018286
protein coding gene Chr11:119022076-119096464 (-)
WSB/EiJ MGP_WSBEiJ_G0018781
protein coding gene Chr11:119237240-119317738 (-)



Homology
more
  • Human Ortholog
    RNF157, ring finger protein 157
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RNF157, ring finger protein 157
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 114804
    neXtProt AC: NX_Q96PX1
    UniProt: Q96PX1

  • Chr Location
    17q25.1; chr17:76142453-76240368 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 28235
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RNF157
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
The gene supports neuronal survival and dendrite growth and maintenance and knockdown with siRNA induces apoptosis in neuronal tissues.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000052949 Ensembl Gene Model | MGI Sequence Detail 76680 C57BL/6J ±  kb
transcript ENSMUST00000100202 Ensembl | MGI Sequence Detail 4619 Not Applicable  
polypeptide ENSMUSP00000097776 Ensembl | MGI Sequence Detail 681 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 9
Other
Accession IDs
less
MGI:1917169
References
more
  • Summaries
    All 32
    Developmental Gene Expression 2
    Gene Ontology 1
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory