About   Help   FAQ
Dgkb
Gene Detail
 Symbol
Name
ID
Dgkb
diacylglycerol kinase, beta
MGI:2442474
Synonyms C630029D13Rik, DGK-beta, mKIAA0718
Feature Type protein coding gene
Genetic Map
Chromosome 12
17.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr12:37880705-38633410 bp, + strand
From NCBI annotation of GRCm38

  752706 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37875  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: diacylglycerol kinase
Gene Tree: Dgkb

Human
homologs
Human Homolog DGKB, diacylglycerol kinase, beta 90kDa
NCBI Gene ID 1607
neXtProt AC  NX_Q9Y6T7
Human Synonyms  DAGK2, DGK, DGK-BETA
Human Chr (Location)  7p21.2; chr7:14145049-14903656 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(4) Targeted(2) Transposon induced(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a transposon distruption have defects in long term potentiation, synapase morphology, and in spatial reference and working memory.
 
Interactions
Dgkb interacts with 351 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process intracellular signal transduction, metabolic process, ...
Component cytoplasm, membrane, ...
Function ATP binding, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (205)    Tissues (131)    Images (40)
Theiler Stages: 19, 22, 23, 28
Assay TypeResults
RNA in situ 203
RT-PCR 2
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) cDNA(20) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000036095 (Evidence)
Entrez Gene217480 (Evidence)
UniGene126525
DFCITC1584322, TC1587612, TC1596164, TC1607237, TC1639003, TC1661084
DoTSDT.110936018, DT.40171700, DT.55213993, DT.91289734, DT.91326727, DT.91354604, DT.91401668, DT.94254612
NIA Mouse Gene IndexU013876, U168246
EC2.7.1.107
Consensus CDS ProjectCCDS25889.1
International Mouse Knockout Project StatusDgkb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 217480 NCBI Gene Model | MGI Sequence Detail 752706 C57BL/6J ±  kb
transcript NM_178681 RefSeq | MGI Sequence Detail 5544 C57BL/6 
polypeptide Q6NS52 UniProt | EBI | MGI Sequence Detail 802 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(14) UniProt(7)
Polymorphisms SNPs within 2kb(4063 from dbSNP Build 137)    SNPs within 2kb including multiple locations(4069)
Protein-related
information
ResourceIDDescription
InterPro IPR016064 ATP-NAD kinase-like domain
InterPro IPR000756 Diacylglycerol kinase, accessory domain
InterPro IPR001206 Diacylglycerol kinase, catalytic domain
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
Protein Ontology PR:000006443 diacylglycerol kinase beta
Graphical View of Protein Domain Structure
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:198682 Leo D, et al., Transgenic mouse models for ADHD. Cell Tissue Res. 2013 May 17;
All references(40)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory