About   Help   FAQ
Dgkb Gene Detail
Summary
  • Symbol
    Dgkb
  • Name
    diacylglycerol kinase, beta
  • Synonyms
    C630029D13Rik, DGK-beta, mKIAA0718
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442474
    NCBI Gene: 217480
  • Alliance
    genome feature page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:37930169-38684238 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 17.11 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    21641 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442474
 protein coding gene Chr12:37867725-38684238 (+)
129S1/SvImJ ENSMUSG00200014653
 protein coding gene Chr12:29733330-30550613 (+)
A/J ENSMUSG00195016736
 protein coding gene Chr12:32577745-33217444 (+)
AKR/J ENSMUSG00220004651
 protein coding gene Chr12:30543304-31196844 (+)
BALB/cJ ENSMUSG00180003329
 protein coding gene Chr12:31564901-32204622 (+)
C3H/HeJ ENSMUSG00175015600
 protein coding gene Chr12:34618346-35257994 (+)
C57BL/6NJ ENSMUSG00215011369
 protein coding gene Chr12:30969309-31622592 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017713
 protein coding gene Chr12:34107555-34817220 (+)
CAST/EiJ ENSTCUG00005003623
 protein coding gene Chr12:31336487-31967228 (+)
CBA/J ENSMUSG00210015744
 protein coding gene Chr12:31097405-31737055 (+)
DBA/2J ENSMUSG00185019260
 protein coding gene Chr12:33119516-33771416 (+)
FVB/NJ ENSMUSG00205001357
 protein coding gene Chr12:31060683-31709219 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230023535
 protein coding gene Chr12:40062466-40715690 (+)
NOD/ShiLtJ ENSMUSG00190017698
 protein coding gene Chr12:30105232-30785739 (+)
NZO/HlLtJ ENSMUSG00225030920
 protein coding gene Chr12:42284394-42937598 (+)
PWK/PhJ ENSLUMG00010011866
 protein coding gene Chr12:31460398-32095603 (+)
SPRET/EiJ ENSMSPG00010001908
 protein coding gene Chr12:32229101-32883562 (+)
WSB/EiJ ENSIUOG00005001219
 protein coding gene Chr12:30835654-31504978 (+)



Homology
more
  • Human Ortholog
    DGKB, diacylglycerol kinase beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DGKB, diacylglycerol kinase beta
  • Synonyms
    DAGK2, DGK, DGK-BETA
  • Links
    NCBI Gene ID: 1607
    UniProt: Q9Y6T7

  • Chr Location
    7p21.2; chr7:14145049-14974858 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a transposon distruption have defects in long term potentiation, synapase morphology, and in spatial reference and working memory.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    802
  • Tissues
    131
  • cDNA Data
    22
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 217480 NCBI Gene Model | MGI Sequence Detail 754070 C57BL/6J ±  kb
    transcript NM_001361686 RefSeq | MGI Sequence Detail 6582 C57BL/6  
    polypeptide Q6NS52 UniProt | EBI | MGI Sequence Detail 802 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000006443 diacylglycerol kinase beta
      (term hierarchy)
    • EC
      2.7.1.107
    • InterPro Domains
      IPR046349 C1-like domain superfamily
      IPR038199 DGK type I, N-terminal domain superfamily
      IPR037607 Diacylglycerol kinase
      IPR000756 Diacylglycerol kinase, accessory domain
      IPR047471 Diacylglycerol kinase beta-like, first protein kinase C conserved region 1
      IPR047470 Diacylglycerol kinase beta, second protein kinase C conserved region 1
      IPR001206 Diacylglycerol kinase, catalytic domain
      IPR029477 Diacylglycerol kinase type I, N-terminal
      IPR018247 EF-Hand 1, calcium-binding site
      IPR002048 EF-hand domain
      IPR011992 EF-hand domain pair
      IPR017438 Inorganic polyphosphate/ATP-NAD kinase, N-terminal
      IPR016064 NAD kinase/diacylglycerol kinase-like domain superfamily
      IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
      IPR028846 Recoverin family
    • GlyGen
      Q6NS52 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 22
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 8
      Gene Ontology 13
      Phenotypes 15
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:390320 Liu Y, et al., Exposure to the prenatal enriched environment alters maternal gut microbiota and promotes embryonic neurodevelopment via activating the AHR-Src pathway. Sci China Life Sci. 2025 Jul;68(7):1964-1979
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory