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Rhbdf2
Gene Detail
Symbol

Name
ID
Rhbdf2
rhomboid 5 homolog 2 (Drosophila)
MGI:2442473
Synonyms
4732465I17Rik, cub, iRhom2, Rhbdl6
Feature Type
protein coding gene
Genetic Map
Chromosome 11
81.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:116598165-116627019 bp, - strand
From VEGA annotation of GRCm38

  28855 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11612  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: RHBDF2
Gene Tree: Rhbdf2

Human
homologs
RHBDF2, rhomboid 5 homolog 2 (Drosophila)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 79651
neXtProt AC: NX_Q6PJF5

Human Synonyms: iRhom2, RHBDL5, RHBDL6, TEC, TOC, TOCG

Human Chr (Location): 17q25.1; chr17:76470893-76501437 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human RHBDF2

Mutations,
alleles, and
phenotypes
All mutations/alleles(41) : Chemically induced (ENU)(3) Gene trapped(32) Spontaneous(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null mutation display impaired TNF secretion and increased sensitivity to bacterial infection induced mortality.
 
Interactions
Rhbdf2 interacts with 127 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process negative regulation of protein secretion, protein transport, ...
Component endoplasmic reticulum, endoplasmic reticulum membrane, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(46)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rhbdf2    NEW 
Molecular
reagents
All nucleic(46) cDNA(46)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000003950 (Evidence)
Ensembl Gene Model ENSMUSG00000020806 (Evidence)
Entrez Gene 217344 (Evidence)
UniGene 89695
DFCI TC1593898, TC1576469
DoTS DT.97390335, DT.91433644, DT.101199896
Consensus CDS Project CCDS25672.1
International Mouse Phenotyping Consortium Status Rhbdf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003950 VEGA Gene Model | MGI Sequence Detail 28855 C57BL/6J ±  kb
transcript OTTMUST00000008766 VEGA | MGI Sequence Detail 3593 Not Applicable 
polypeptide OTTMUSP00000004274 VEGA | MGI Sequence Detail 827 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(6) UniProt(2)
Polymorphisms
SNPs within 2kb(137 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002610 Peptidase S54, rhomboid
InterPro IPR022764 Peptidase S54, rhomboid domain
InterPro IPR022241 Rhomboid serine protease
Protein Ontology PR:000013969 inactive rhomboid protein 2
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:217394 Siggs OM, et al., Genetic interaction implicates iRhom2 in the regulation of EGF receptor signalling in mice. Biol Open. 2014;3(12):1151-7
All references(44)
Other
accession IDs
MGI:1890800

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory