Rhbdf2
Gene Detail

Symbol Name ID

Rhbdf2 rhomboid 5 homolog 2 (Drosophila) MGI:2442473

Synonyms

4732465I17Rik, iRhom2, Rhbdl6

Feature Type

protein coding gene

Genetic Map

Chromosome 11

81.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr11:116598165-116627019 bp, - strand From VEGA annotation of GRCm38   28855 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:11612  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Rhbdf2

Human homologs

Human Homolog		RHBDF2, rhomboid 5 homolog 2 (Drosophila)
NCBI Gene ID		79651
neXtProt AC		NX_Q6PJF5
Human Synonyms		RHBDL5, RHBDL6, TOC
Human Chr (Location)		17q25.1; chr17:74466975-74497509 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human RHBDF2

Alleles and phenotypes

All alleles(37) : Targeted(4) Gene trapped(32) Chemically induced(1)
 

Mice homozygous for a null mutation display impaired TNF secretion and increased sensitivity to bacterial infection induced mortality.

 

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	negative regulation of protein secretion, protein transport, ...
Component	endoplasmic reticulum, endoplasmic reticulum membrane, ...

External Resources: FuncBase

Expression

cDNA source data(45)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(45) cDNA(45)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000003950 (Evidence)
Ensembl Gene Model	ENSMUSG00000020806 (Evidence)
Entrez Gene	217344 (Evidence)
UniGene	89695
DFCI	TC1576469, TC1593898
DoTS	DT.101199896, DT.91433644, DT.97390335
Consensus CDS Project	CCDS25672.1
International Mouse Knockout Project Status	Rhbdf2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000003950	VEGA Gene Model | MGI Sequence Detail	28855	C57BL/6J
transcript	OTTMUST00000008766	VEGA | MGI Sequence Detail	3593	Not Applicable
polypeptide	OTTMUSP00000004274	VEGA | MGI Sequence Detail	827	Not Applicable

All sequences(36) RefSeq(4) UniProt(2)

Polymorphisms

SNPs(107 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002610	Peptidase S54, rhomboid
InterPro	IPR022764	Peptidase S54, rhomboid domain
InterPro	IPR022241	Rhomboid serine protease
Protein Ontology	PR:000013969	inactive rhomboid protein 2

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:194483 Issuree PD, et al., iRHOM2 is a critical pathogenic mediator of inflammatory arthritis. J Clin Invest. 2013 Jan 25;
All references(36)