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Thoc2 Gene Detail
Summary
  • Symbol
    Thoc2
  • Name
    THO complex 2
  • Synonyms
    6330441O12Rik, D130005M13Rik, LOC382210, LOC386493
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442413
    NCBI Gene: 331401
  • Gene Overview
    MyGene.info: THOC2
Location & Maps
more
  • Sequence Map
    ChrX:41794991-41920674 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      125684 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 23.19 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    THOC2, THO complex 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    THOC2, THO complex 2
    Orthology source: HomoloGene
  • Synonyms
    CXorf3, dJ506G2.1, hTREX120, MRX12, MRX35, THO2
  • Links
    NCBI Gene ID: 57187
    neXtProt AC: NX_Q8NI27

  • Chr Location
    Xq25-q26.3; chrX:123600561-123733054 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 69669
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: THOC2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human THOC2 associations

Human Disease Mouse Models
       Mental Retardation, X-Linked 12; MRX12   OMIM: 300957
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017445 VEGA Gene Model | MGI Sequence Detail 125684 C57BL/6J ±  kb
transcript OTTMUST00000042314 VEGA | MGI Sequence Detail 7622 Not Applicable  
polypeptide OTTMUSP00000019011 VEGA | MGI Sequence Detail 1594 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    145 from dbSNP Build 142
Protein
Information
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  • UniProt
    12 Sequences
  • Protein Ontology
    PR:000016311 THO complex subunit 2
  • InterPro Domains
    IPR032302 THO complex subunit 2, N-terminal domain
    IPR021418 THO complex, subunitTHOC2, C-terminal
    IPR021726 THO complex, subunitTHOC2, N-terminal
Molecular
Reagents
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  • All nucleic 96
    cDNA 95
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:2685985, MGI:2686639, MGI:3036266
References
more
  • Summaries
    All 27
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 2
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:204143 Wang L, et al., The THO Complex Regulates Pluripotency Gene mRNA Export and Controls Embryonic Stem Cell Self-Renewal and Somatic Cell Reprogramming. Cell Stem Cell. 2013 Dec 5;13(6):676-90

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory