Dpp10 MGI Mouse Gene Detail - MGI:2442409

Symbol

Dpp10
Name

dipeptidylpeptidase 10
Synonyms

6430601K09Rik, DPRP3

Feature Type

protein coding gene
IDs

MGI:2442409
NCBI Gene: 269109
Gene Overview

MyGene.info: DPP10
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr1:123332138-124845815 bp, - strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 53.68 cM
Mapping Data

1 experiment

SNPs within 2kb

13646 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442409	protein coding gene	Chr1:123321471-124846039 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016413	protein coding gene	Chr1:126277450-127053062 (-)
A/J	MGP_AJ_G0016396	protein coding gene	Chr1:121694113-122426919 (-)
AKR/J	MGP_AKRJ_G0016361	protein coding gene	Chr1:125247361-126012082 (-)
BALB/cJ	MGP_BALBcJ_G0016356	protein coding gene	Chr1:121997531-122751717 (-)
C3H/HeJ	MGP_C3HHeJ_G0016182	protein coding gene	Chr1:125463167-126226313 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016817	protein coding gene	Chr1:131066973-131856097 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014530	protein coding gene	Chr1:115225936-115924735 (-)
CAST/EiJ	MGP_CASTEiJ_G0015763	protein coding gene	Chr1:124304649-125107512 (-)
CBA/J	MGP_CBAJ_G0016155	protein coding gene	Chr1:135547049-136375629 (-)
DBA/2J	MGP_DBA2J_G0016261	protein coding gene	Chr1:120739425-121471350 (-)
FVB/NJ	MGP_FVBNJ_G0016260	protein coding gene	Chr1:119456332-120197657 (-)
LP/J	MGP_LPJ_G0016332	protein coding gene	Chr1:127602475-128378096 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016285	protein coding gene	Chr1:141386945-142288706 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016853	protein coding gene	Chr1:125014257-125780938 (-)
PWK/PhJ	MGP_PWKPhJ_G0015549	protein coding gene	Chr1:119693557-120411247 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015337	protein coding gene	Chr1:123953416-124741265 (-)
WSB/EiJ	MGP_WSBEiJ_G0015825	protein coding gene	Chr1:124908220-125682437 (-)

Human Ortholog

DPP10, dipeptidyl peptidase like 10

Vertebrate Orthologs

11

Human Ortholog

DPP10, dipeptidyl peptidase like 10
Orthology source: HomoloGene, HGNC
Synonyms

DPL2, DPPY, DPRP3, DPRP-3
Links

HGNC:20823

NCBI Gene ID: 57628

neXtProt AC: NX_Q8N608

UniProt: Q8N608
Chr Location

2q14.1; chr2:114442358-115845752 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 41400
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: DPP10
Protein SuperFamily

dipeptidyl-peptidase IV
Gene Tree

Dpp10

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (ENU)

1
Chemically induced (other)

2
Gene trapped

1
Radiation induced

1
Targeted

2
Genomic Mutations

3 involving Dpp10
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

28 strains or lines available

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All GO Annotations

17
GO References

8

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

634
Tissues

3
cDNA Data

7
Literature Summary

3

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dpp10

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Dpp10 interacts with 347 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

49
RefSeq

8
UniProt

4
CCDS

CCDS15241.2

Ensembl

ENSMUSG00000036815 (Evidence)
NCBI Gene

269109

			Length	Strain/Species	Flank
genomic	269109	NCBI Gene Model \| MGI Sequence Detail	1513678	C57BL/6J	± kb
transcript	NM_199021	RefSeq \| MGI Sequence Detail	4648	C57BL/6
polypeptide	Q6NXK7	UniProt \| EBI \| MGI Sequence Detail	797	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000006659 inactive dipeptidyl peptidase 10

(term hierarchy)
InterPro Domains

IPR029058 Alpha/Beta hydrolase fold

IPR002469 Dipeptidylpeptidase IV, N-terminal domain

IPR038554 Dipeptidylpeptidase IV, N-terminal domain superfamily

IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain

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All nucleic 7

cDNA 7

Microarray probesets 3

Summaries

All 37

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 11
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:257086 Zhang Y, et al., Manipulation of dipeptidylpeptidase 10 in mouse and human in vivo and in vitro models indicates a protective role in asthma. Dis Model Mech. 2018 Jan 29;11(1)

TSS for Dpp10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr13315	Chr1:124046003-124046085 (-)	799,771 bp
Tssr13314	Chr1:124045977-124045989 (-)	799,832 bp
Tssr13313	Chr1:124045523-124045571 (-)	800,268 bp
Tssr13312	Chr1:124045487-124045522 (-)	800,310 bp
Tssr13311	Chr1:124045283-124045294 (-)	800,526 bp
Tssr13310	Chr1:124045247-124045267 (-)	800,558 bp
Tssr13309	Chr1:124045211-124045235 (-)	800,592 bp
Tssr13305	Chr1:123853954-123853957 (-)	991,859 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 02/16/2021 MGI 6.16