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Syne3 Gene Detail
Summary
  • Symbol
    Syne3
  • Name
    spectrin repeat containing, nuclear envelope family member 3
  • Synonyms
    4831426I19Rik, nesprin-3, nesprin-3alpha, nesprin-3beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442408
    NCBI Gene: 212073
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:104929933-105009809 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 54.97 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    520 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442408
protein coding gene Chr12:104929933-105010098 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020082
protein coding gene Chr12:106756449-106809520 (-)
A/J MGP_AJ_G0020036
protein coding gene Chr12:102702761-102746230 (-)
AKR/J MGP_AKRJ_G0020013
protein coding gene Chr12:105659644-105713740 (-)
BALB/cJ MGP_BALBcJ_G0020022
protein coding gene Chr12:103110514-103160370 (-)
C3H/HeJ MGP_C3HHeJ_G0019825
protein coding gene Chr12:106136970-106185411 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020468
protein coding gene Chr12:110053502-110101682 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018081
protein coding gene Chr12:99416717-99494832 (-)
CAST/EiJ MGP_CASTEiJ_G0019366
protein coding gene Chr12:100972609-101065297 (-)
CBA/J MGP_CBAJ_G0019792
protein coding gene Chr12:114309157-114354857 (-)
DBA/2J MGP_DBA2J_G0019909
protein coding gene Chr12:102250854-102298392 (-)
FVB/NJ MGP_FVBNJ_G0019894
protein coding gene Chr12:101040656-101086216 (-)
LP/J MGP_LPJ_G0019984
protein coding gene Chr12:106622848-106689472 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019932
protein coding gene Chr12:117755317-117807022 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020497
protein coding gene Chr12:105088411-105165245 (-)
PWK/PhJ MGP_PWKPhJ_G0019129
protein coding gene Chr12:96770984-96831218 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018931
protein coding gene Chr12:99359947-99406780 (-)
WSB/EiJ MGP_WSBEiJ_G0019425
protein coding gene Chr12:106069598-106120063 (-)



Homology
more
  • Human Ortholog
    SYNE3, spectrin repeat containing nuclear envelope family member 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SYNE3, spectrin repeat containing nuclear envelope family member 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C14orf139, C14orf49, KASH3, LINC00341, NCRNA00341, Nesp3, NET53
  • Links
    NCBI Gene ID: 161176
    neXtProt AC: NX_Q6ZMZ3
    UniProt: Q6ZMZ3

  • Chr Location
    14q32.13; chr14:95416083-95516693 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Targeted
    2
  • Genomic Mutations
    1 involving Syne3
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054150 Ensembl Gene Model | MGI Sequence Detail 79877 C57BL/6J ±  kb
transcript ENSMUST00000095439 Ensembl | MGI Sequence Detail 3357 Not Applicable  
polypeptide ENSMUSP00000093090 Ensembl | MGI Sequence Detail 975 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    Genomic 2
    cDNA 10

    Microarray probesets 2
References
more
  • Summaries
    All 39
    Developmental Gene Expression 3
    Gene Ontology 9
    Phenotypes 9
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:252201 Rapisarda V, et al., p63 Transcription Factor Regulates Nuclear Shape and Expression of Nuclear Envelope-Associated Genes in Epidermal Keratinocytes. J Invest Dermatol. 2017 Oct;137(10):2157-2167

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory