Syne3
Gene Detail

Symbol Name ID

Syne3 spectrin repeat containing, nuclear envelope family member 3 MGI:2442408

Synonyms

4831426I19Rik, nesprin-3, nesprin-3alpha, nesprin-3beta

Feature Type

protein coding gene

Genetic Map

Chromosome 12

54.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr12:104929949-105009809 bp, - strand From NCBI annotation of GRCm38   79861 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:17625  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Syne3

Human homologs

Human Homolog		SYNE3, spectrin repeat containing, nuclear envelope family member 3
NCBI Gene ID		161176
neXtProt AC		NX_Q6ZMZ3
Human Synonyms		C14orf49, Nesp3, NET53
Human Chr (Location)		14q32.13; chr14:95883831-95942173 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(1) Gene trapped(3)

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	cytoskeletal anchoring at nuclear membrane, cytoskeleton organization, ...
Component	integral to membrane, membrane, ...
Function	actin binding, protein binding

External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(11) Genomic(1) cDNA(10)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000054150 (Evidence)
Entrez Gene	212073 (Evidence)
UniGene	212688
DFCI	TC1586790
DoTS	DT.101291368, DT.40151516
NIA Mouse Gene Index	U034313
Consensus CDS Project	CCDS36542.1, CCDS36543.1
International Mouse Knockout Project Status	Syne3

Sequences

Length	Strain/Species
genomic	212073	NCBI Gene Model | MGI Sequence Detail	79861	C57BL/6J
transcript	NM_001042699	RefSeq | MGI Sequence Detail	5436	Not Specified
polypeptide	Q4FZC9	UniProt | EBI | MGI Sequence Detail	975	Not Applicable

All sequences(24) RefSeq(4) UniProt(1)

Polymorphisms

SNPs(364 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR012315	Klarsicht/ANC-1/syne-1 homology
InterPro	IPR018159	Spectrin/alpha-actinin
InterPro	IPR002017	Spectrin repeat
Protein Ontology	PR:000031027	nesprin-3

Graphical View of Protein Domain Structure

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:190404 Morimoto A, et al., A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis. J Cell Biol. 2012 Jul 23;198(2):165-72
All references(32)