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Cnot1 Gene Detail
Summary
  • Symbol
    Cnot1
  • Name
    CCR4-NOT transcription complex, subunit 1
  • Synonyms
    6030411K04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442402
    NCBI Gene: 234594
  • Gene Overview
    MyGene.info: CNOT1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:95719451-95807464 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 47.18 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    268 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442402
protein coding gene Chr8:95719451-95807505 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033993
protein coding gene Chr8:97225646-97322947 (-)
A/J MGP_AJ_G0033976
protein coding gene Chr8:93398512-93486307 (-)
AKR/J MGP_AKRJ_G0033902
protein coding gene Chr8:95979651-96071135 (-)
BALB/cJ MGP_BALBcJ_G0033968
protein coding gene Chr8:93491702-93580450 (-)
C3H/HeJ MGP_C3HHeJ_G0033678
protein coding gene Chr8:96683377-96778492 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034489
protein coding gene Chr8:100791698-100893448 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031430
protein coding gene Chr8:87199408-87287924 (-)
CAST/EiJ MGP_CASTEiJ_G0033010
protein coding gene Chr8:96271758-96364120 (-)
CBA/J MGP_CBAJ_G0033654
protein coding gene Chr8:104082009-104175516 (-)
DBA/2J MGP_DBA2J_G0033808
protein coding gene Chr8:92893858-92985337 (-)
FVB/NJ MGP_FVBNJ_G0033755
protein coding gene Chr8:91855329-91944104 (-)
LP/J MGP_LPJ_G0033900
protein coding gene Chr8:97357493-97451784 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033797
protein coding gene Chr8:106298690-106393920 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034507
protein coding gene Chr8:96137392-96234268 (-)
PWK/PhJ MGP_PWKPhJ_G0032712
protein coding gene Chr8:92258399-92348799 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032549
protein coding gene Chr8:94976275-95065222 (-)
WSB/EiJ MGP_WSBEiJ_G0033122
protein coding gene Chr8:96655511-96748104 (-)



Homology
more
  • Human Ortholog
    CNOT1, CCR4-NOT transcription complex subunit 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CNOT1, CCR4-NOT transcription complex subunit 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AD-005, CDC39, NOT1, NOT1H
  • Links
    NCBI Gene ID: 23019
    neXtProt AC: NX_A5YKK6
    UniProt: A5YKK6

  • Chr Location
    16q21; chr16:58519946-58629886 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9453
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CNOT1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice hmozygous for a conditional allele activated in cardiomyocytes exhibit postnatal lethality, decreased cardiac muscle contractility, prolonged QT interval and cardiac muscle cell death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036550 Ensembl Gene Model | MGI Sequence Detail 88014 C57BL/6J ±  kb
    transcript ENSMUST00000098473 Ensembl | MGI Sequence Detail 8390 Not Applicable  
    polypeptide ENSMUSP00000096073 Ensembl | MGI Sequence Detail 2376 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • Protein Ontology
      PR:000005648 CCR4-NOT transcription complex subunit 1
    • InterPro Domains
      IPR007196 CCR4-Not complex component, Not1, C-terminal
      IPR024557 CCR4-Not complex, Not1 subunit, domain of unknown function DUF3819
      IPR038535 CCR4-NOT subunit 1, TTP binding domain superfamily
      IPR032191 CCR4-NOT transcription complex subunit 1, CAF1-binding domain
      IPR032194 CCR4-NOT transcription complex subunit 1, HEAT repeat
      IPR032193 CCR4-NOT transcription complex subunit 1, TTP binding domain
      IPR016021 MIF4G-like domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 284
      cDNA 283
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:3034660
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 8
      Gene Ontology 7
      Phenotypes 7
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:260012 Yamaguchi T, et al., The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function. Sci Signal. 2018 Feb 6;11(516)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory