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Ppp1r9a
Gene Detail
Symbol

Name
ID
Ppp1r9a
protein phosphatase 1, regulatory (inhibitor) subunit 9A
MGI:2442401
Synonyms
2810430P21Rik, 4930518N04Rik, A230094E16Rik, mKIAA1222, neurabin-I, Neurabin I, NRB
Feature Type
protein coding gene
Genetic Map
Chromosome 6
1.86 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:4902917-5165661 bp, + strand
From VEGA annotation of GRCm38

  262745 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:14247  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ppp1r9a

Human
homologs
Human Homolog PPP1R9A, protein phosphatase 1, regulatory subunit 9A
NCBI Gene ID 55607
neXtProt AC  NX_Q9ULJ8
Human Synonyms  Neurabin-I, NRB1, NRBI
Human Chr (Location)  7q21.3; chr7:94907637-95296415 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(102) : Gene trapped(98) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit defects in dopamine-mediated neuromodulation, deficient long-term potentiation at corticostriatal synapses, increased spontaneous excitatory post-synaptic current frequency, and enhanced locomotor activation in response to cocaine treatment.
 
Interactions
Ppp1r9a interacts with 489 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process actin filament organization, calcium-mediated signaling, ...
Component cortical actin cytoskeleton, cytoskeleton, ...
Function actin filament binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (91)    Tissues (38)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 48
Northern blot 14
Western blot 2
RT-PCR 27
cDNA source data(54)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(58) cDNA(55) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000042256 (Evidence)
Ensembl Gene ModelENSMUSG00000032827 (Evidence)
Entrez Gene243725 (Evidence)
UniGene332901
DoTSDT.101140412, DT.101387017, DT.101387020, DT.101387021, DT.110472825, DT.40149429, DT.55212034, DT.55281608, DT.87035476, DT.94128962, DT.94252835
NIA Mouse Gene IndexU042714
Consensus CDS ProjectCCDS19897.1
International Mouse Knockout Project StatusPpp1r9a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042256 VEGA Gene Model | MGI Sequence Detail 262745 C57BL/6J ±  kb
transcript OTTMUST00000111117 VEGA | MGI Sequence Detail 3975 Not Applicable 
polypeptide OTTMUSP00000062112 VEGA | MGI Sequence Detail 1292 Not Applicable 

For the selected sequences
All sequences(121) RefSeq(34) UniProt(13)
Polymorphisms
SNPs within 2kb(215 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001478 PDZ domain
InterPro IPR001660 Sterile alpha motif domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR011510 Sterile alpha motif, type 2
Protein Ontology PR:000013132 neurabin-1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:182503 Chen Y, et al., Neurabin scaffolding of adenosine receptor and RGS4 regulates anti-seizure effect of endogenous adenosine. J Neurosci. 2012 Feb 22;32(8):2683-95
All references(49)
Other
accession IDs
MGI:1919984, MGI:2141739

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory