Peak1 Gene Detail

Summary

• Symbol
  Peak1
• Name
  pseudopodium-enriched atypical kinase 1
• Synonyms
  1110049L02Rik, C230081A13Rik, NKF3 kinase family member

• Feature Type
  protein coding gene
• IDs
  MGI:2442366
  NCBI Gene: 244895
• Alliance
  gene page
• Transcription Start Sites
  5 TSS

Location &
Maps

• Sequence Map
  Chr9:56201126-56418067 bp, - strand
• From Ensembl annotation of GRCm38
  

  View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 9, 30.13 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  583 from dbSNP Build 142
• Strain Annotations
  17

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442366	protein coding gene	Chr9:56201126-56418230 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0034849	protein coding gene	Chr9:55341598-55559888 (-)
A/J	MGP_AJ_G0034830	protein coding gene	Chr9:53544089-53762064 (-)
AKR/J	MGP_AKRJ_G0034759	protein coding gene	Chr9:54792035-55012829 (-)
BALB/cJ	MGP_BALBcJ_G0034822	protein coding gene	Chr9:53332235-53550658 (-)
C3H/HeJ	no annotation
C57BL/6NJ	MGP_C57BL6NJ_G0035341	protein coding gene	Chr9:56897627-57131544 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032252	protein coding gene	Chr9:52896783-53113758 (-)
CAST/EiJ	MGP_CASTEiJ_G0033853	protein coding gene	Chr9:55289501-55521763 (-)
CBA/J	MGP_CBAJ_G0034503	protein coding gene	Chr9:58851061-59089790 (-)
DBA/2J	MGP_DBA2J_G0034662	protein coding gene	Chr9:53440597-53655485 (-)
FVB/NJ	MGP_FVBNJ_G0034604	protein coding gene	Chr9:52638211-52853852 (-)
LP/J	MGP_LPJ_G0034745	protein coding gene	Chr9:55627878-55844526 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034647	protein coding gene	Chr9:60372918-60613050 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035363	protein coding gene	Chr9:54788576-55011827 (-)
PWK/PhJ	MGP_PWKPhJ_G0033558	protein coding gene	Chr9:53444841-53665932 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033392	protein coding gene	Chr9:55075462-55293706 (-)
WSB/EiJ	MGP_WSBEiJ_G0033966	protein coding gene	Chr9:54726398-54947024 (-)

Homology

• Human Ortholog
  PEAK1, pseudopodium enriched atypical kinase 1

• Vertebrate Orthologs
  10

• Human Ortholog
  PEAK1, pseudopodium enriched atypical kinase 1
  Orthology source: HomoloGene, HGNC
• Synonyms
  SGK269
• Links
  HGNC:29431

  NCBI Gene ID: 79834

  neXtProt AC: NX_Q9H792

  UniProt: Q9H792

  
  
• Chr Location
  15q24.3; chr15:77100829-77420104 (-)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 18259
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: PEAK1
• Gene Tree
  Peak1
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  8 phenotype references
  

• All Mutations and Alleles
  32
• Endonuclease-mediated
  1
• Gene trapped
  31
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  14 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  19
• GO References
  5

• External Resources
  FuncBase

Expression

• cDNA Data
  15

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase peak1

Interactions

• Peak1 interacts with 503 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

Sequences &
Gene Models

• All Sequences
  53
• RefSeq
  6
• UniProt
  3
• CCDS
  CCDS52804.1

• Ensembl
  ENSMUSG00000074305 (Evidence)
• NCBI Gene
  244895

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000074305	Ensembl Gene Model | MGI Sequence Detail	216942	C57BL/6J
transcript	ENSMUST00000061552	Ensembl | MGI Sequence Detail	6996	Not Applicable
polypeptide	ENSMUSP00000109901	Ensembl | MGI Sequence Detail	1735	Not Applicable

Protein
Information

• UniProt
  3 Sequences
• Protein Ontology
  PR:000029132 inactive tyrosine-protein kinase PEAK1
  (term hierarchy)
• InterPro Domains
  IPR000719 Protein kinase domain
  IPR011009 Protein kinase-like domain superfamily
  IPR008266 Tyrosine-protein kinase, active site

Molecular
Reagents

• All nucleic 15

  cDNA 15

  
  

  Microarray probesets 7

Other
Accession IDs

MGI:1916011, MGI:2142963, MGI:3034954

References

• Summaries
  All 34

  Gene Ontology 5

  Phenotypes 8
• Earliest
  J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
• Latest
  J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

TSS for Peak1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr89709	Chr9:56418099-56418110 (-)	-38 bp
Tssr89708	Chr9:56418061-56418081 (-)	-4 bp
Tssr89707	Chr9:56418023-56418052 (-)	29 bp
Tssr89701	Chr9:56244050-56244099 (-)	173,992 bp
Tssr89700	Chr9:56244035-56244047 (-)	174,026 bp