Peak1 MGI Mouse Gene Detail - MGI:2442366 - pseudopodium-enriched atypical kinase 1

Symbol

Peak1
Name

pseudopodium-enriched atypical kinase 1
Synonyms

1110049L02Rik, C230081A13Rik, NKF3 kinase family member

Feature Type

protein coding gene
IDs

MGI:2442366
NCBI Gene: 244895
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr9:56201126-56418067 bp, - strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 30.13 cM
Mapping Data

2 experiments

SNPs within 2kb

583 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442366	protein coding gene	Chr9:56201126-56418222 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0034849	protein coding gene	Chr9:55341598-55559888 (-)
A/J	MGP_AJ_G0034830	protein coding gene	Chr9:53544089-53762064 (-)
AKR/J	MGP_AKRJ_G0034759	protein coding gene	Chr9:54792035-55012829 (-)
BALB/cJ	MGP_BALBcJ_G0034822	protein coding gene	Chr9:53332235-53550658 (-)
C3H/HeJ	no annotation
C57BL/6NJ	MGP_C57BL6NJ_G0035341	protein coding gene	Chr9:56897627-57131544 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032252	protein coding gene	Chr9:52896783-53113758 (-)
CAST/EiJ	MGP_CASTEiJ_G0033853	protein coding gene	Chr9:55289501-55521763 (-)
CBA/J	MGP_CBAJ_G0034503	protein coding gene	Chr9:58851061-59089790 (-)
DBA/2J	MGP_DBA2J_G0034662	protein coding gene	Chr9:53440597-53655485 (-)
FVB/NJ	MGP_FVBNJ_G0034604	protein coding gene	Chr9:52638211-52853852 (-)
LP/J	MGP_LPJ_G0034745	protein coding gene	Chr9:55627878-55844526 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034647	protein coding gene	Chr9:60372918-60613050 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035363	protein coding gene	Chr9:54788576-55011827 (-)
PWK/PhJ	MGP_PWKPhJ_G0033558	protein coding gene	Chr9:53444841-53665932 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033392	protein coding gene	Chr9:55075462-55293706 (-)
WSB/EiJ	MGP_WSBEiJ_G0033966	protein coding gene	Chr9:54726398-54947024 (-)

Human Ortholog

PEAK1, pseudopodium enriched atypical kinase 1

Vertebrate Orthologs

10

Human Ortholog

PEAK1, pseudopodium enriched atypical kinase 1
Orthology source: HomoloGene, HGNC
Synonyms

SGK269
Links

HGNC:29431

NCBI Gene ID: 79834

neXtProt AC: NX_Q9H792

UniProt: Q9H792
Chr Location

15q24.3; chr15:77100829-77420104 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 18259
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: PEAK1
Gene Tree

Peak1

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

34
Endonuclease-mediated

1
Gene trapped

31
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

46 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit reduced angiogenesis in postnatal retina, VEGFA-treated aortas, and transplanted breast cancer cells infected with VEGFA-expressing adenovirus.

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All GO Annotations

19
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

631
cDNA Data

15

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase peak1

ZFIN peak1

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Peak1 interacts with 503 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

55
RefSeq

8
UniProt

3
CCDS

CCDS52804.1

Ensembl

ENSMUSG00000074305 (Evidence)
NCBI Gene

244895

			Length	Strain/Species	Flank
genomic	ENSMUSG00000074305	Ensembl Gene Model \| MGI Sequence Detail	216942	C57BL/6J	± kb
transcript	ENSMUST00000061552	Ensembl \| MGI Sequence Detail	6996	Not Applicable
polypeptide	ENSMUSP00000109901	Ensembl \| MGI Sequence Detail	1735	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000029132 inactive tyrosine-protein kinase PEAK1

(term hierarchy)
InterPro Domains

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008266 Tyrosine-protein kinase, active site

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All nucleic 15

cDNA 15

Microarray probesets 7

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MGI:1916011, MGI:2142963, MGI:3034954

Summaries

All 35

Gene Ontology 5

Phenotypes 9
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:278882 Wang H, et al., Pseudopodium-enriched atypical kinase 1 mediates angiogenesis by modulating GATA2-dependent VEGFR2 transcription. Cell Discov. 2018;4:26

TSS for Peak1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr89709	Chr9:56418099-56418110 (-)	-38 bp
Tssr89708	Chr9:56418061-56418081 (-)	-4 bp
Tssr89707	Chr9:56418023-56418052 (-)	29 bp
Tssr89701	Chr9:56244050-56244099 (-)	173,992 bp
Tssr89700	Chr9:56244035-56244047 (-)	174,026 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 02/16/2021 MGI 6.16