Arl15 MGI Mouse Gene Detail - MGI:2442308 - ADP-ribosylation factor-like 15

Symbol

Arl15
Name

ADP-ribosylation factor-like 15
Synonyms

Arfrp2, C230032K13Rik

Feature Type

protein coding gene
IDs

MGI:2442308
NCBI Gene: 218639
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr13:113931041-114293997 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 64.02 cM
Mapping Data

2 experiments

SNPs within 2kb

4125 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442308	protein coding gene	Chr13:113929963-114293998 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020954	protein coding gene	Chr13:116459413-116845044 (+)
A/J	MGP_AJ_G0020904	protein coding gene	Chr13:111797960-112166100 (+)
AKR/J	MGP_AKRJ_G0020879	protein coding gene	Chr13:115133965-115498465 (+)
BALB/cJ	MGP_BALBcJ_G0020904	protein coding gene	Chr13:112471612-112836403 (+)
C3H/HeJ	MGP_C3HHeJ_G0020693	protein coding gene	Chr13:114938422-115309957 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021340	protein coding gene	Chr13:119900826-120276271 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018909	protein coding gene	Chr13:107039611-107402324 (+)
CAST/EiJ	MGP_CASTEiJ_G0020212	protein coding gene	Chr13:114605496-114985480 (+)
CBA/J	MGP_CBAJ_G0020655	protein coding gene	Chr13:124486315-124874588 (+)
DBA/2J	MGP_DBA2J_G0020778	protein coding gene	Chr13:111476343-111838136 (+)
FVB/NJ	MGP_FVBNJ_G0020762	protein coding gene	Chr13:110158567-110530599 (+)
LP/J	MGP_LPJ_G0020854	protein coding gene	Chr13:116487725-116863881 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020790	protein coding gene	Chr13:124756932-125155573 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021376	protein coding gene	Chr13:114630131-115009652 (+)
PWK/PhJ	no annotation
SPRET/EiJ	MGP_SPRETEiJ_G0019787	protein coding gene	Chr13:110933366-111309658 (+)
WSB/EiJ	MGP_WSBEiJ_G0020270	protein coding gene	Chr13:115219101-115598493 (+)

Human Ortholog

ARL15, ADP ribosylation factor like GTPase 15

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARL15, ADP ribosylation factor like GTPase 15
Synonyms

ARFRP2
Links

HGNC:25945

NCBI Gene ID: 54622

neXtProt AC: NX_Q9NXU5

UniProt: Q9NXU5
Chr Location

5q11.2; chr5:53883942-54310582 (-) GRCh38

MGI Vertebrate Homology

Arl15 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ARL15
Gene Tree

Arl15

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

342
Endonuclease-mediated

2
Gene trapped

335
Targeted

5
Incidental Mutations

APF
Find Mice (IMSR)

362 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

2
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

776
Tissues

34
cDNA Data

23
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase arl15

ZFIN arl15b

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All Sequences

54
RefSeq

10
UniProt

3
CCDS

CCDS36785.1

Ensembl

ENSMUSG00000042348 (Evidence)
NCBI Gene

218639

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042348	Ensembl Gene Model \| MGI Sequence Detail	362957	C57BL/6J	± kb
transcript	ENSMUST00000091201	Ensembl \| MGI Sequence Detail	3364	Not Applicable
polypeptide	ENSMUSP00000088740	Ensembl \| MGI Sequence Detail	204	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000004279 ADP-ribosylation factor-like protein 15

(term hierarchy)
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR006689 Small GTPase superfamily, ARF/SAR type

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All nucleic 23

cDNA 23

Microarray probesets 4

Summaries

All 45

Developmental Gene Expression 3

Gene Ontology 2

Phenotypes 20
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:342550 Gupta N, et al., Essential role of Mg(2+) in mouse preimplantation embryo development revealed by TRPM7 chanzyme-deficient gametes. Cell Rep. 2023 Oct 31;42(10):113232

TSS for Arl15:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr121189	Chr13:113931051-113931108 (+)	39 bp
Tssr121190	Chr13:113931140-113931154 (+)	106 bp
Tssr121191	Chr13:113931155-113931166 (+)	120 bp
Tssr121192	Chr13:113931182-113931207 (+)	154 bp
Tssr121193	Chr13:113954702-113954717 (+)	23,669 bp
Tssr121194	Chr13:114007207-114007224 (+)	76,175 bp
Tssr121195	Chr13:114017723-114017756 (+)	86,699 bp
Tssr121196	Chr13:114118017-114118031 (+)	186,983 bp
Tssr121197	Chr13:114126286-114126289 (+)	195,247 bp
Tssr121198	Chr13:114185023-114185028 (+)	253,985 bp
Tssr121199	Chr13:114247710-114247712 (+)	316,670 bp
Tssr121200	Chr13:114250100-114250104 (+)	319,061 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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