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Usp28 Gene Detail
Summary
  • Symbol
    Usp28
  • Name
    ubiquitin specific peptidase 28
  • Synonyms
    9830148O20Rik, mKIAA1515
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442293
    NCBI Gene: 235323
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:48985375-49042517 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 26.56 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    239 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442293
protein coding gene Chr9:48985333-49042517 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034767
protein coding gene Chr9:47783679-47855673 (+)
A/J MGP_AJ_G0034748
protein coding gene Chr9:46367492-46428784 (+)
AKR/J MGP_AKRJ_G0034676
protein coding gene Chr9:47338643-47399032 (+)
BALB/cJ MGP_BALBcJ_G0034740
protein coding gene Chr9:46090742-46149948 (+)
C3H/HeJ MGP_C3HHeJ_G0034450
protein coding gene Chr9:47793268-47851430 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035260
protein coding gene Chr9:49153225-49213869 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032173
protein coding gene Chr9:45857450-45915204 (+)
CAST/EiJ MGP_CASTEiJ_G0033772
protein coding gene Chr9:47741381-47798315 (+)
CBA/J MGP_CBAJ_G0034422
protein coding gene Chr9:50891589-50962722 (+)
DBA/2J MGP_DBA2J_G0034581
protein coding gene Chr9:46226608-46283538 (+)
FVB/NJ MGP_FVBNJ_G0034522
protein coding gene Chr9:45473332-45531792 (+)
LP/J MGP_LPJ_G0034662
protein coding gene Chr9:48164524-48224487 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034566
protein coding gene Chr9:52580045-52645607 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035281
protein coding gene Chr9:47272656-47339843 (+)
PWK/PhJ MGP_PWKPhJ_G0033477
protein coding gene Chr9:46192238-46250131 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033312
protein coding gene Chr9:47587041-47650746 (+)
WSB/EiJ MGP_WSBEiJ_G0033885
protein coding gene Chr9:47313569-47372778 (+)



Homology
more
  • Human Ortholog
    USP28, ubiquitin specific peptidase 28
  • Vertebrate Orthologs
    10
  • Human Ortholog
    USP28, ubiquitin specific peptidase 28
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 57646
    neXtProt AC: NX_Q96RU2
    UniProt: Q96RU2

  • Chr Location
    11q23.2; chr11:113797875-113875580 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 10840
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: USP28
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and fertile and exhibit slightly decreased spleen weight and splenocyte number but show neither major signaling defects in DNA damage response nor developmental defects indicative of impaired double-strand break metabolism.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032267 Ensembl Gene Model | MGI Sequence Detail 57143 C57BL/6J ±  kb
    transcript ENSMUST00000047349 Ensembl | MGI Sequence Detail 4133 Not Applicable  
    polypeptide ENSMUSP00000047467 Ensembl | MGI Sequence Detail 1051 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 126
      cDNA 124
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143214
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 4
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:262372 Richter K, et al., USP28 Deficiency Promotes Breast and Liver Carcinogenesis as well as Tumor Angiogenesis in a HIF-independent Manner. Mol Cancer Res. 2018 Jun;16(6):1000-1012

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    06/11/2019
    MGI 6.14
    The Jackson Laboratory