About   Help   FAQ
Cgas Gene Detail
Summary
  • Symbol
    Cgas
  • Name
    cyclic GMP-AMP synthase
  • Synonyms
    E330016A19Rik, Mb21d1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442261
    NCBI Gene: 214763
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:78430526-78443237 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 43.65 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    96 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442261
protein coding gene Chr9:78430518-78443525 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035069
protein coding gene Chr9:78936596-78950476 (-)
A/J MGP_AJ_G0035050
protein coding gene Chr9:76211973-76223940 (-)
AKR/J MGP_AKRJ_G0034978
protein coding gene Chr9:78016097-78028368 (-)
BALB/cJ MGP_BALBcJ_G0035038
protein coding gene Chr9:75872695-75883997 (-)
C3H/HeJ MGP_C3HHeJ_G0034750
protein coding gene Chr9:78536374-78547562 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035559
protein coding gene Chr9:81066956-81080990 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032468
protein coding gene Chr9:75441587-75453970 (-)
CAST/EiJ MGP_CASTEiJ_G0034069
protein coding gene Chr9:78816751-78830664 (-)
CBA/J MGP_CBAJ_G0034723
protein coding gene Chr9:83930016-83941251 (-)
DBA/2J MGP_DBA2J_G0034881
protein coding gene Chr9:75853352-75864547 (-)
FVB/NJ MGP_FVBNJ_G0034824
protein coding gene Chr9:75083731-75095319 (-)
LP/J MGP_LPJ_G0034962
protein coding gene Chr9:79164291-79178210 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034866
protein coding gene Chr9:85113706-85128742 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035582
protein coding gene Chr9:78184390-78196869 (-)
PWK/PhJ MGP_PWKPhJ_G0033771
protein coding gene Chr9:76046576-76060547 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033608
protein coding gene Chr9:78382316-78397098 (-)
WSB/EiJ MGP_WSBEiJ_G0034184
protein coding gene Chr9:78127771-78142080 (-)



Homology
more
  • Human Ortholog
    CGAS, cyclic GMP-AMP synthase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CGAS, cyclic GMP-AMP synthase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C6orf150, h-cGAS, MB21D1
  • Links
    NCBI Gene ID: 115004
    neXtProt AC: NX_Q8N884
    UniProt: Q8N884

  • Chr Location
    6q13; chr6:73423711-73452330 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 51384
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CGAS
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased susceptibility to viral infection and abnormal innate immunity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032344 Ensembl Gene Model | MGI Sequence Detail 12712 C57BL/6J ±  kb
    transcript ENSMUST00000070742 Ensembl | MGI Sequence Detail 4049 Not Applicable  
    polypeptide ENSMUSP00000063331 Ensembl | MGI Sequence Detail 507 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 23

      Microarray probesets 7
    References
    more
    • Summaries
      All 81
      Developmental Gene Expression 1
      Gene Ontology 11
      Phenotypes 39
    • Earliest
      J:12013 Russell LB, Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations. Mutat Res. 1971 Jan;11(1):107-23
    • Latest
      J:265099 Cheng WY, et al., The cGas-Sting Signaling Pathway Is Required for the Innate Immune Response Against Ectromelia Virus. Front Immunol. 2018;9:1297

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory