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Mb21d1 Gene Detail
Summary
  • Symbol
    Mb21d1
  • Name
    Mab-21 domain containing 1
  • Synonyms
    cGas, E330016A19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442261
    NCBI Gene: 214763
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:78430526-78443237 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12712 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 43.65 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CGAS, cyclic GMP-AMP synthase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CGAS, cyclic GMP-AMP synthase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C6orf150, h-cGAS, MB21D1
  • Links
    NCBI Gene ID: 115004
    neXtProt AC: NX_Q8N884
    UniProt: Q8N884

  • Chr Location
    6q13; chr6:73423711-73452330 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 51384
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CGAS
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased susceptibility to viral infection and abnormal innate immunity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000019697 VEGA Gene Model | MGI Sequence Detail 12712 C57BL/6J ±  kb
    transcript OTTMUST00000047159 VEGA | MGI Sequence Detail 4049 Not Applicable  
    polypeptide OTTMUSP00000021298 VEGA | MGI Sequence Detail 507 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      96 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 22

      Microarray probesets 7
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 1
      Gene Ontology 10
      Phenotypes 31
    • Earliest
      J:12013 Russell LB, Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations. Mutat Res. 1971 Jan;11(1):107-23
    • Latest
      J:255750 Kerur N, et al., cGAS drives noncanonical-inflammasome activation in age-related macular degeneration. Nat Med. 2018 Jan;24(1):50-61

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory