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Gsap
Gene Detail
Symbol

Name
ID
Gsap
gamma-secretase activating protein
MGI:2442259
Synonyms
A530088I07Rik, Pion
Feature Type
protein coding gene
Genetic Map
Chromosome 5
9.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:21186267-21291701 bp, + strand
From Ensembl annotation of GRCm38

  105435 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:45504  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: GSAP
Gene Tree: Gsap

Human
homologs
GSAP, gamma-secretase activating protein
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 54103
neXtProt AC: NX_A4D1B5

Human Synonyms: PION

Human Chr (Location): 7q11.23; chr7:77310751-77416408 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Gsap interacts with 164 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process positive regulation of beta-amyloid formation, regulation of proteolysis
Component Golgi apparatus, trans-Golgi network
Function beta-amyloid binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (30)    Tissues (6)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 30
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(17)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000039934 (Evidence)
Entrez Gene 212167 (Evidence)
UniGene 121705
DFCI TC1580763, TC1611473, TC1594314, TC1631216
DoTS DT.91329304, DT.101715875, DT.101339008, DT.87049685, DT.94259918
NIA Mouse Gene Index U005332
Consensus CDS Project CCDS39021.1
International Mouse Phenotyping Consortium Status Gsap
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039934 Ensembl Gene Model | MGI Sequence Detail 105435 C57BL/6J ±  kb
transcript ENSMUST00000036031 Ensembl | MGI Sequence Detail 3745 Not Applicable 
polypeptide ENSMUSP00000043679 Ensembl | MGI Sequence Detail 858 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(16) UniProt(1)
Polymorphisms
SNPs within 2kb(781 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026172 Gamma-secretase-activating protein family
Protein Ontology PR:000012739 protein pigeon
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(24)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory