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Gsap Gene Detail
Summary
  • Symbol
    Gsap
  • Name
    gamma-secretase activating protein
  • Synonyms
    A530088I07Rik, Pion
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442259
    NCBI Gene: 212167
  • Gene Overview
    MyGene.info: GSAP
Location & Maps
more
  • Sequence Map
    Chr5:21186255-21315132 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      128878 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    GSAP, gamma-secretase activating protein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GSAP, gamma-secretase activating protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PION
  • Links
    NCBI Gene ID: 54103
    neXtProt AC: NX_A4D1B5

  • Chr Location
    7q11.23; chr7:77310751-77416408 (-)  GRCh38.p2

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    4 involving Gsap
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000053218 VEGA Gene Model | MGI Sequence Detail 128878 C57BL/6J ±  kb
transcript OTTMUST00000132957 VEGA | MGI Sequence Detail 3745 Not Applicable  
polypeptide OTTMUSP00000070802 VEGA | MGI Sequence Detail 858 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    949 from dbSNP Build 142
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000012739 protein pigeon
  • InterPro Domains
    IPR028010 Gamma-secretase-activating protein, C-terminal domain
    IPR026172 Gamma-secretase-activating protein family
Molecular
Reagents
less
  • All nucleic 17
    cDNA 17

    Microarray probesets 3
References
more
  • Summaries
    All 22
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 3
    Phenotypes 11
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory