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Pdpr Gene Detail
Summary
  • Symbol
    Pdpr
  • Name
    pyruvate dehydrogenase phosphatase regulatory subunit
  • Synonyms
    4930402E16Rik, mKIAA1990
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442188
    NCBI Gene: 319518
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr8:111094630-111137074 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 57.95 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    86 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442188
protein coding gene Chr8:111094606-111139781 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034136
protein coding gene Chr8:113827517-113874404 (+)
A/J MGP_AJ_G0034115
protein coding gene Chr8:109209683-109254447 (+)
AKR/J MGP_AKRJ_G0034042
protein coding gene Chr8:112406455-112455043 (+)
BALB/cJ MGP_BALBcJ_G0034109
protein coding gene Chr8:109385877-109430703 (+)
C3H/HeJ MGP_C3HHeJ_G0033820
protein coding gene Chr8:113129047-113173538 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034629
protein coding gene Chr8:117824144-117874584 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031571
protein coding gene Chr8:102187536-102231212 (+)
CAST/EiJ MGP_CASTEiJ_G0033147
protein coding gene Chr8:112743567-112790604 (+)
CBA/J MGP_CBAJ_G0033794
protein coding gene Chr8:121830572-121882478 (+)
DBA/2J MGP_DBA2J_G0033949
protein coding gene Chr8:108498982-108542882 (+)
FVB/NJ MGP_FVBNJ_G0033893
protein coding gene Chr8:107457159-107499316 (+)
LP/J MGP_LPJ_G0034039
protein coding gene Chr8:114002214-114047163 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033939
protein coding gene Chr8:124721619-124767478 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034648
protein coding gene Chr8:112379368-112427960 (+)
PWK/PhJ MGP_PWKPhJ_G0032850
protein coding gene Chr8:108077855-108123506 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032689
protein coding gene Chr8:111060163-111100558 (+)
WSB/EiJ MGP_WSBEiJ_G0033263
protein coding gene Chr8:113059063-113105897 (+)



Homology
more
  • Human Ortholog
    PDPR, pyruvate dehydrogenase phosphatase regulatory subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PDPR, pyruvate dehydrogenase phosphatase regulatory subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PDP3
  • Links
    NCBI Gene ID: 55066
    neXtProt AC: NX_Q8NCN5
    UniProt: Q8NCN5

  • Chr Location
    16q22.1; chr16:70113626-70163630 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9948
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PDPR
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033624 Ensembl Gene Model | MGI Sequence Detail 42445 C57BL/6J ±  kb
transcript ENSMUST00000039333 Ensembl | MGI Sequence Detail 4938 Not Applicable  
polypeptide ENSMUSP00000046639 Ensembl | MGI Sequence Detail 878 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000012517 pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial
  • InterPro Domains
    IPR006222 Aminomethyltransferase, folate-binding domain
    IPR006076 FAD dependent oxidoreductase
    IPR032503 FAD dependent oxidoreductase, central domain
    IPR036188 FAD/NAD(P)-binding domain superfamily
    IPR013977 Glycine cleavage T-protein, C-terminal barrel domain
    IPR029043 Glycine cleavage T-protein/YgfZ, C-terminal
    IPR027266 GTP-binding protein TrmE/Glycine cleavage system T protein, domain 1
Molecular
Reagents
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  • All nucleic 16
    cDNA 16

    Microarray probesets 6
Other
Accession IDs
less
MGI:2142683
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:236179 Bowman CE, et al., Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series. Mol Cell Biol. 2016 Aug 1;36(15):2089-104

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory