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Bank1 Gene Detail
Summary
  • Symbol
    Bank1
  • Name
    B cell scaffold protein with ankyrin repeats 1
  • Synonyms
    A530094C12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442120
    NCBI Gene: 242248
Location & Maps
more
  • Sequence Map
    Chr3:136053363-136326066 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      272704 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 63.04 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    BANK1, B-cell scaffold protein with ankyrin repeats 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    BANK1, B-cell scaffold protein with ankyrin repeats 1
    Orthology source: HomoloGene
  • Synonyms
    BANK
  • Links
    NCBI Gene ID: 55024
    neXtProt AC: NX_Q8NDB2

  • Chr Location
    4q24; chr4:101790607-102074812 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human BANK1 associations

Human Disease Mouse Models
       Systemic Lupus Erythematosus; SLE   OMIM: 152700
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Bank1
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit increased germinal center formation and IgM production in response to T-dependent antigens, and show enhanced CD40-mediated B cell proliferative and survival responses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000052558 VEGA Gene Model | MGI Sequence Detail 272704 C57BL/6J ±  kb
transcript OTTMUST00000131761 VEGA | MGI Sequence Detail 3268 Not Applicable  
polypeptide OTTMUSP00000070387 VEGA | MGI Sequence Detail 783 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2294 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000004639 B-cell scaffold protein with ankyrin repeats
  • InterPro Domains
    IPR020683 Ankyrin repeat-containing domain
    IPR017893 DBB domain
Molecular
Reagents
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  • All nucleic 27
    cDNA 27

    Microarray probesets 3
Other
Accession IDs
less
MGI:2139723
References
more
  • Summaries
    All 29
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:207126 Wu YY, et al., BANK1 controls CpG-induced IL-6 secretion via a p38 and MNK1/2/eIF4E translation initiation pathway. J Immunol. 2013 Dec 15;191(12):6110-6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory