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Itga11 Gene Detail
Summary
  • Symbol
    Itga11
  • Name
    integrin alpha 11
  • Synonyms
    4732459H24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442114
    NCBI Gene: 319480
  • Gene Overview
    MyGene.info: ITGA11
Location & Maps
more
  • Sequence Map
    Chr9:62677826-62783982 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      106157 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ITGA11, integrin subunit alpha 11
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ITGA11, integrin subunit alpha 11
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HsT18964
  • Links
    NCBI Gene ID: 22801
    neXtProt AC: NX_Q9UKX5

  • Chr Location
    15q23; chr15:68297428-68432160 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Targeted
    7
  • Genomic Mutations
    1 involving Itga11
  • Incidental Mutations
Mice homozygous for a disruption of this gene display dwarfism, increased mortality with age, and defective incisors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026249 VEGA Gene Model | MGI Sequence Detail 106157 C57BL/6J ±  kb
transcript OTTMUST00000064915 VEGA | MGI Sequence Detail 4969 Not Applicable  
polypeptide OTTMUSP00000032280 VEGA | MGI Sequence Detail 1188 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    660 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 2
References
more
  • Summaries
    All 29
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:220715 Schulz JN, et al., Reduced Granulation Tissue and Wound Strength in the Absence of alpha11beta1 Integrin. J Invest Dermatol. 2015 May;135(5):1435-44

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory