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Itga11 Gene Detail
Summary
  • Symbol
    Itga11
  • Name
    integrin alpha 11
  • Synonyms
    4732459H24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442114
    NCBI Gene: 319480
  • Gene Overview
    MyGene.info: ITGA11
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:62677826-62783982 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      106157 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 33.82 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    ITGA11, integrin subunit alpha 11
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ITGA11, integrin subunit alpha 11
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HsT18964
  • Links
    NCBI Gene ID: 22801
    neXtProt AC: NX_Q9UKX5
    UniProt: Q9UKX5

  • Chr Location
    15q23; chr15:68297433-68432312 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption of this gene display dwarfism, increased mortality with age, and defective incisors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000026249 VEGA Gene Model | MGI Sequence Detail 106157 C57BL/6J ±  kb
    transcript OTTMUST00000064915 VEGA | MGI Sequence Detail 4969 Not Applicable  
    polypeptide OTTMUSP00000032280 VEGA | MGI Sequence Detail 1188 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      660 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 2
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 3
      Gene Ontology 4
      Phenotypes 14
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:249223 Reigstad I, et al., Stromal Integrin alpha11beta1 Affects RM11 Prostate and 4T1 Breast Xenograft Tumors Differently. PLoS One. 2016;11(3):e0151663

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory