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Ppm1k Gene Detail
Summary
  • Symbol
    Ppm1k
  • Name
    protein phosphatase 1K (PP2C domain containing)
  • Synonyms
    2900063A19Rik, A930026L03Rik, PP2Cm
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442111
    NCBI Gene: 243382
  • Gene Overview
    MyGene.info: PPM1K
Location & Maps
more
  • Sequence Map
    Chr6:57506502-57535468 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28967 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 27.82 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PPM1K, protein phosphatase, Mg2+/Mn2+ dependent 1K
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PPM1K, protein phosphatase, Mg2+/Mn2+ dependent 1K
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BDP, MSUDMV, PP2Ckappa, PP2Cm, PTMP, UG0882E07
  • Links
    NCBI Gene ID: 152926
    neXtProt AC: NX_Q8N3J5

  • Chr Location
    4q22.1; chr4:88257609-88284831 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 36819
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PPM1K
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Ppm1k mouse models; 1 with human PPM1K associations

Human Disease Mouse Models
       Maple Syrup Urine Disease; MSUD   OMIM: 248600 View 1 model
       Maple Syrup Urine Disease, Mild Variant; MSUDMV   OMIM: 615135
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Gene trapped
    4
  • Targeted
    2
  • Incidental Mutations
    APF
Mice homozygous for a null allele exhibit defective amino acid metabolism, increased oxidative stress, and increased mortality when subjected to a high-protein diet while in utero and during postnatal development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000039933 VEGA Gene Model | MGI Sequence Detail 28967 C57BL/6J ±  kb
transcript OTTMUST00000103768 VEGA | MGI Sequence Detail 5560 Not Applicable  
polypeptide OTTMUSP00000058002 VEGA | MGI Sequence Detail 372 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    209 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 7
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1920294
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:230107 Lian K, et al., Impaired adiponectin signaling contributes to disturbed catabolism of branched-chain amino acids in diabetic mice. Diabetes. 2015 Jan;64(1):49-59

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory