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Ppm1k
Gene Detail
Symbol

Name
ID
Ppm1k
protein phosphatase 1K (PP2C domain containing)
MGI:2442111
Synonyms
2900063A19Rik, A930026L03Rik, PP2Cm
Feature Type
protein coding gene
Genetic Map
Chromosome 6
27.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:57506502-57535426 bp, - strand
From VEGA annotation of GRCm38

  28925 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36819  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PPM1K
Gene Tree: Ppm1k

Human
homologs
PPM1K, protein phosphatase, Mg2+/Mn2+ dependent, 1K
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 152926
neXtProt AC: NX_Q8N3J5

Human Synonyms: BDP, MSUDMV, PP2Ckappa, PP2Cm, PTMP, UG0882E07

Human Chr (Location): 4q22.1; chr4:88257609-88284831 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PPM1K

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(4) Targeted(2)
Incidental mutations (data from APF )
 
Mice homozygous for a null allele exhibit defective amino acid metabolism, increased oxidative stress, and increased mortality when subjected to a high-protein diet while in utero and during postnatal development.
 
Human Diseases Modeled in Mice Using Ppm1k (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Ppm1k interacts with 388 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process protein dephosphorylation
Component mitochondrion
Function catalytic activity, cation binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (65)    Tissues (25)    Images (39)    Tissue x Stage Matrix (view)
Assay TypeResults
In situ reporter (knock in) 35
Western blot 18
RT-PCR 12
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ppm1k ; ZFIN ppm1k    NEW 
Molecular
reagents
All nucleic(8) cDNA(7) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000039933 (Evidence)
Ensembl Gene Model ENSMUSG00000037826 (Evidence)
Entrez Gene 243382 (Evidence)
DFCI TC1586706, TC1599468
NIA Mouse Gene Index U027361
EC 3.1.3.16
Consensus CDS Project CCDS20183.1
International Mouse Phenotyping Consortium Status Ppm1k
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000039933 VEGA Gene Model | MGI Sequence Detail 28925 C57BL/6J ±  kb
transcript OTTMUST00000103768 VEGA | MGI Sequence Detail 5560 Not Applicable 
polypeptide OTTMUSP00000058002 VEGA | MGI Sequence Detail 372 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(8) UniProt(2)
Polymorphisms
SNPs within 2kb(209 from dbSNP Build 137)    SNPs within 2kb including multiple locations(211)
Protein-related
information
ResourceIDDescription
InterPro IPR015655 Protein phosphatase 2C
InterPro IPR000222 Protein phosphatase 2C, manganese/magnesium aspartate binding site
InterPro IPR001932 Protein phosphatase 2C (PP2C)-like
Protein Ontology PR:000013098 protein phosphatase 1K, mitochondrial
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:205327 Zimmerman HA, et al., Adipose transplant for inborn errors of branched chain amino acid metabolism in mice. Mol Genet Metab. 2013 Aug;109(4):345-53
All references(31)
Disease annotation references (1)
Other
accession IDs
MGI:1920294

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory