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Ppm1k Gene Detail
Summary
  • Symbol
    Ppm1k
  • Name
    protein phosphatase 1K (PP2C domain containing)
  • Synonyms
    2900063A19Rik, A930026L03Rik, PP2Cm
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442111
    NCBI Gene: 243382
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:57483487-57512453 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 6, 27.82 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    209 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442111
protein coding gene Chr6:57483487-57512537 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030800
protein coding gene Chr6:57015642-57048828 (-)
A/J MGP_AJ_G0030772
protein coding gene Chr6:54416885-54445875 (-)
AKR/J MGP_AKRJ_G0030696
protein coding gene Chr6:56259154-56288065 (-)
BALB/cJ MGP_BALBcJ_G0030783
protein coding gene Chr6:54801267-54829521 (-)
C3H/HeJ MGP_C3HHeJ_G0030496
protein coding gene Chr6:56326361-56362808 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031238
protein coding gene Chr6:58321875-58350979 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028445
protein coding gene Chr6:52633985-52659075 (+)
CAST/EiJ MGP_CASTEiJ_G0029892
protein coding gene Chr6:56074019-56102043 (-)
CBA/J MGP_CBAJ_G0030467
protein coding gene Chr6:60746439-60784078 (-)
DBA/2J MGP_DBA2J_G0030618
protein coding gene Chr6:54263425-54291068 (-)
FVB/NJ MGP_FVBNJ_G0030571
protein coding gene Chr6:53869929-53899201 (-)
LP/J MGP_LPJ_G0030703
protein coding gene Chr6:56956599-56988511 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030605
protein coding gene Chr6:63185015-63217313 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031262
protein coding gene Chr6:56160909-56234039 (-)
PWK/PhJ MGP_PWKPhJ_G0029610
protein coding gene Chr6:53996085-54026257 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029437
protein coding gene Chr6:55483422-55511023 (-)
WSB/EiJ MGP_WSBEiJ_G0029973
protein coding gene Chr6:56270527-56303173 (-)



Homology
more
  • Human Ortholog
    PPM1K, protein phosphatase, Mg2+/Mn2+ dependent 1K
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPM1K, protein phosphatase, Mg2+/Mn2+ dependent 1K
  • Synonyms
    BCKDH, BDP, MSUDMV, PP2Ckappa, PP2Cm, PTMP, UG0882E07
  • Links
    NCBI Gene ID: 152926
    neXtProt AC: NX_Q8N3J5
    UniProt: Q8N3J5

  • Chr Location
    4q22.1; chr4:88257620-88284769 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with Ppm1k mouse models; 1 with human PPM1K associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit defective amino acid metabolism, increased oxidative stress, and increased mortality when subjected to a high-protein diet while in utero and during postnatal development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037826 Ensembl Gene Model | MGI Sequence Detail 28967 C57BL/6J ±  kb
    transcript ENSMUST00000042766 Ensembl | MGI Sequence Detail 5560 Not Applicable  
    polypeptide ENSMUSP00000041395 Ensembl | MGI Sequence Detail 372 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 8
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1920294
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 7
      Phenotypes 21
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory