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Nipa1 Gene Detail
Summary
  • Symbol
    Nipa1
  • Name
    non imprinted in Prader-Willi/Angelman syndrome 1 homolog (human)
  • Synonyms
    1110027G09Rik, A830014A18Rik, Spg6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442058
    NCBI Gene: 233280
  • Gene Overview
    MyGene.info: NIPA1
Location & Maps
more
  • Sequence Map
    Chr7:55977567-56019954 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      42388 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 33.42 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NIPA1, non imprinted in Prader-Willi/Angelman syndrome 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NIPA1, non imprinted in Prader-Willi/Angelman syndrome 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FSP3, SPG6
  • Links
    NCBI Gene ID: 123606
    neXtProt AC: NX_Q7RTP0

  • Chr Location
    15q11.2; chr15:22786225-22829789 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human NIPA1 associations

Human Disease Mouse Models
       Spastic Paraplegia 6, Autosomal Dominant; SPG6   OMIM: 600363
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotype references
  • All Mutations and Alleles
    3
  • Targeted
    3
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026329 VEGA Gene Model | MGI Sequence Detail 42388 C57BL/6J ±  kb
transcript OTTMUST00000065116 VEGA | MGI Sequence Detail 3183 Not Applicable  
polypeptide OTTMUSP00000032412 VEGA | MGI Sequence Detail 323 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    537 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000011217 magnesium transporter NIPA1
  • InterPro Domains
    IPR008521 Magnesium transporter NIPA
Molecular
Reagents
less
  • All nucleic 5
    cDNA 4
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1915904
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:213427 Adissu HA, et al., Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen. Dis Model Mech. 2014 May;7(5):515-24

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory