Pld5 Gene Detail

Summary

• Symbol
  Pld5
• Name
  phospholipase D family, member 5
• Synonyms
  B230365F16Rik

• Feature Type
  protein coding gene
• IDs
  MGI:2442056
  NCBI Gene: 319455
• Gene Overview
  MyGene.info: PLD5
• Alliance
  gene page
• Transcription Start Sites
  10 TSS

Location &
Maps

• Sequence Map
  Chr1:175962306-176275312 bp, - strand
• From Ensembl annotation of GRCm38
  

  View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 1, 81.90 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  3709 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442056	protein coding gene	Chr1:175962301-176276850 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016843	protein coding gene	Chr1:182061612-182410043 (-)
A/J	MGP_AJ_G0016822	protein coding gene	Chr1:174732707-175061428 (-)
AKR/J	MGP_AKRJ_G0016788	protein coding gene	Chr1:179967111-180303184 (-)
BALB/cJ	MGP_BALBcJ_G0016780	protein coding gene	Chr1:175266078-175590518 (-)
C3H/HeJ	MGP_C3HHeJ_G0016605	protein coding gene	Chr1:180558010-180891866 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017245	protein coding gene	Chr1:188074788-188419583 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014950	protein coding gene	Chr1:166050055-166373974 (-)
CAST/EiJ	MGP_CASTEiJ_G0016186	protein coding gene	Chr1:179933558-180263970 (-)
CBA/J	MGP_CBAJ_G0016579	protein coding gene	Chr1:194909158-195272819 (-)
DBA/2J	MGP_DBA2J_G0016684	protein coding gene	Chr1:173588967-173911215 (-)
FVB/NJ	MGP_FVBNJ_G0016681	protein coding gene	Chr1:171707845-172027255 (-)
LP/J	MGP_LPJ_G0016760	protein coding gene	Chr1:183255000-183599740 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016713	protein coding gene	Chr1:202167965-202518887 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017280	protein coding gene	Chr1:179717266-180055588 (-)
PWK/PhJ	MGP_PWKPhJ_G0015973	protein coding gene	Chr1:172679950-173003784 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015750	protein coding gene	Chr1:178756670-179100539 (-)
WSB/EiJ	MGP_WSBEiJ_G0016248	protein coding gene	Chr1:179923391-180253810 (-)

Homology

• Human Ortholog
  PLD5, phospholipase D family member 5

• Vertebrate Orthologs
  9

• Human Ortholog
  PLD5, phospholipase D family member 5
  Orthology source: HGNC, HomoloGene
• Synonyms
  PLDC
• Links
  HGNC:26879

  NCBI Gene ID: 200150

  neXtProt AC: NX_Q8N7P1

  UniProt: Q8N7P1

  
  
• Chr Location
  1q43; chr1:242085051-242530546 (-)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 16081
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 macaque, rhesus
  
• HCOP
  human homology predictions: PLD5
• Protein SuperFamily
  phospholipase D, chordopox type
• Gene Tree
  Pld5
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  4 phenotypes from 2 alleles in 2 genetic backgrounds
  10 phenotype references
  

• All Mutations and Alleles
  5
• Chemically induced (other)
  2
• Gene trapped
  1
• Targeted
  2
• Genomic Mutations
  2 involving Pld5
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  29 strains or lines available

No abnormal phenotype was observed in a high-throughput screen, nor in a pathology assessment.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  3
• GO References
  2

• External Resources
  FuncBase

Expression

• cDNA Data
  10
• Literature Summary
  1

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Interactions

• Pld5 interacts with 291 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

Sequences &
Gene Models

• All Sequences
  66
• RefSeq
  22
• UniProt
  5
• CCDS
  CCDS15552.1, CCDS56660.1
• UniGene
  338001

• Ensembl
  ENSMUSG00000055214 (Evidence)
• NCBI Gene
  319455

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000055214	Ensembl Gene Model | MGI Sequence Detail	313007	C57BL/6J
transcript	ENSMUST00000065967	Ensembl | MGI Sequence Detail	3557	Not Applicable
polypeptide	ENSMUSP00000069326	Ensembl | MGI Sequence Detail	536	Not Applicable

Protein
Information

• UniProt
  5 Sequences
• Protein Ontology
  PR:000012847 inactive phospholipase D5
  (term hierarchy)
• InterPro Domains
  IPR001736 Phospholipase D/Transphosphatidylase
  IPR032803 PLD-like domain

Molecular
Reagents

• All nucleic 10

  cDNA 10

  
  

  Microarray probesets 1

References

• Summaries
  All 28

  Developmental Gene Expression 1

  Gene Ontology 2

  Phenotypes 10
• Earliest
  J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
• Latest
  J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

TSS for Pld5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr15411	Chr1:176275283-176275308 (-)	16 bp
Tssr15410	Chr1:176214041-176214047 (-)	61,268 bp
Tssr15409	Chr1:176214015-176214024 (-)	61,292 bp
Tssr15408	Chr1:176213974-176213977 (-)	61,336 bp
Tssr15407	Chr1:176213958-176213967 (-)	61,349 bp
Tssr15406	Chr1:176213934-176213943 (-)	61,373 bp
Tssr15405	Chr1:176213769-176213779 (-)	61,538 bp
Tssr15404	Chr1:176213740-176213747 (-)	61,568 bp
Tssr15403	Chr1:176213704-176213718 (-)	61,601 bp
Tssr15402	Chr1:176213673-176213684 (-)	61,633 bp