Pld5 Gene Detail

Summary

• Symbol
  Pld5
• Name
  phospholipase D family, member 5
• Synonyms
  B230365F16Rik

• Feature Type
  protein coding gene
• IDs
  MGI:2442056
  NCBI Gene: 319455
• Gene Overview
  MyGene.info: PLD5
• Alliance
  gene page

Location & Maps

• Sequence Map
  Chr1:175962306-176275312 bp, - strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    313007 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 1, 81.90 cM
• Mapping Data
  1 experiment

Homology

• Human Ortholog
  PLD5, phospholipase D family member 5

• Vertebrate Orthologs
  9

• Human Ortholog
  PLD5, phospholipase D family member 5
  Orthology source: HomoloGene, HGNC
• Synonyms
  PLDC
• Links
  HGNC:26879

  NCBI Gene ID: 200150

  neXtProt AC: NX_Q8N7P1

  UniProt: Q8N7P1

  
  
• Chr Location
  1q43; chr1:242085051-242530546 (-)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 16081
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 macaque, rhesus
  
• HCOP
  human homology predictions: PLD5
• Protein SuperFamily
  phospholipase D, chordopox type
• Gene Tree
  Pld5
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  4 phenotypes from 2 alleles in 2 genetic backgrounds
  10 phenotype references
  

• All Mutations and Alleles
  5
• Chemically induced (other)
  2
• Gene trapped
  1
• Targeted
  2
• Genomic Mutations
  2 involving Pld5
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  25 strains or lines available

No abnormal phenotype was observed in a high-throughput screen, nor in a pathology assessment.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  3
• GO References
  2

• External Resources
  FuncBase

Expression

• cDNA Data
  8
• Literature Summary
  1

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Interactions

• Pld5 interacts with 291 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

Sequences &
Gene Models

• All Sequences
  59
• RefSeq
  22
• UniProt
  5
• CCDS
  CCDS15552.1, CCDS56660.1
• UniGene
  338001

• VEGA
  OTTMUSG00000024158 (Evidence)
• Ensembl
  ENSMUSG00000055214 (Evidence)
• NCBI Gene
  319455

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000024158	VEGA Gene Model | MGI Sequence Detail	313007	C57BL/6J
transcript	OTTMUST00000059164	VEGA | MGI Sequence Detail	3557	Not Applicable
polypeptide	OTTMUSP00000028754	VEGA | MGI Sequence Detail	536	Not Applicable

Polymorphisms

• SNPs within 2kb
  3709 from dbSNP Build 142

Protein
Information

• UniProt
  5 Sequences
• Protein Ontology
  PR:000012847 inactive phospholipase D5
  (term hierarchy)
• InterPro Domains
  IPR001736 Phospholipase D/Transphosphatidylase
  IPR032803 PLD-like domain

Molecular
Reagents

• All nucleic 8

  cDNA 8

  
  

  Microarray probesets 1

References

• Summaries
  All 28

  Developmental Gene Expression 1

  Gene Ontology 2

  Phenotypes 10
• Earliest
  J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
• Latest
  J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514